RESUMEN
Adaptive behavior is fundamental to cognitive control and executive functioning. This study investigates how cognitive control mechanisms and episodic feature retrieval interact to influence adaptiveness, focusing particularly on theta (4 to 8 Hz) oscillatory dynamics. We conducted two variations of the Simon task, incorporating response-incompatible, response-compatible, and neutral trials. Experiment 1 demonstrated that cognitive adjustments-specifically, cognitive shielding following incompatible trials and cognitive relaxation following compatible ones-are reflected in midfrontal theta power modulations associated with the Simon effect. Experiment 2 showed that reducing feature overlap between trials leads to less pronounced sequential modulations in behavior and midfrontal theta activity, supporting the hypothesis that cognitive control and feature integration share a common neural mechanism. These findings highlight the interaction of cognitive control processes and episodic feature integration in modulating behavior. The results advocate for hybrid models that combine top-down and bottom-up processes as a comprehensive framework to understand cognitive control dynamics and adaptive behavior.
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Cognición , Conflicto Psicológico , Función Ejecutiva , Ritmo Teta , Humanos , Ritmo Teta/fisiología , Masculino , Femenino , Adulto Joven , Cognición/fisiología , Adulto , Función Ejecutiva/fisiología , Tiempo de Reacción/fisiología , Electroencefalografía , Desempeño Psicomotor/fisiología , Adaptación Psicológica/fisiología , Encéfalo/fisiologíaRESUMEN
According to action control theories, responding to a stimulus leads to the binding of response and stimulus features into a common representation, that is, an event file. Repeating any component of an event file retrieves all previously bound information, leading to performance costs for partial repetitions measured in so-called binding effects. Although otherwise robust and stable, binding effects are typically completely absent in "localization tasks," in which participants localize targets with spatially compatible responses. Yet, it is possible to observe binding effects in such when location features have to be translated into response features. We hypothesized that this modulation of binding effects is reflected in task involvement of the dorsolateral pFC (DLPFC). Participants localized targets with either direct (i.e., spatially compatible key) or translated (i.e., diagonally opposite to the spatially compatible key) responses. We measured DLPFC activity with functional near-infrared spectroscopy. On the behavioral level, we observed binding effects in the translated response condition, but not in the direct response condition. Importantly, prefrontal activity was also higher in the translated mapping condition. In addition, we found some evidence for the strength of the difference in binding effects in behavioral data being correlated with the corresponding effects in prefrontal activity. This suggests that activity in the DLPFC reflects the amount of executive control needed for translating location features into responses. More generally, binding effects seem to emerge only when the task at hand involves DLPFC recruitment.
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Función Ejecutiva , Corteza Prefrontal , Humanos , Corteza Prefrontal/fisiología , Función Ejecutiva/fisiologíaRESUMEN
Executive functions are essential for adaptive behavior. One executive function is the so-called 'interference control' or conflict monitoring another one is inhibitory control (i.e., action restraint and action cancelation). Recent evidence suggests an interplay of these processes, which is conceptually relevant given that newer conceptual frameworks imply that nominally different action/response control processes are explainable by a small set of cognitive and neurophysiological processes. The existence of such overarching neural principles has as yet not directly been examined. In the current study, we therefore use EEG tensor decomposition methods, to look into possible common neurophysiological signatures underlying conflict-modulated action restraint and action cancelation as mechanism underlying response inhibition. We show how conflicts differentially modulate action restraint and action cancelation processes and delineate common and distinct neural processes underlying this interplay. Concerning the spatial information modulations are similar in terms of an importance of processes reflected by parieto-occipital electrodes, suggesting that attentional selection processes play a role. Especially theta and alpha activity seem to play important roles. The data also show that tensor decomposition is sensitive to the manner of task implementation, thereby suggesting that switch probability/transitional probabilities should be taken into consideration when choosing tensor decomposition as analysis method. The study provides a blueprint of how to use tensor decomposition methods to delineate common and distinct neural mechanisms underlying action control functions using EEG data.
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Conflicto Psicológico , Electroencefalografía , Función Ejecutiva , Humanos , Electroencefalografía/métodos , Masculino , Función Ejecutiva/fisiología , Femenino , Adulto , Adulto Joven , Encéfalo/fisiología , Inhibición Psicológica , Desempeño Psicomotor/fisiologíaRESUMEN
In recent years, there has been many efforts to establish a comprehensive theoretical framework explaining the working mechanisms involved in perception-action integration. This framework stresses the importance of the immediate past on mechanisms supporting perception-action integration. The present study investigates the neurophysiological principles of dynamic perception-action bindings, particularly considering the influence of the immediate history on action control mechanisms. For this purpose, we conducted an established stimulus-response binding paradigm during EEG recording. The SR-task measures stimulus-response binding in terms of accuracy and reaction time differences depending on the degree of feature overlap between conditions. Alpha, beta and theta band activity in distinct time domains as well as associated brain regions were investigated applying time-frequency analyses, a beamforming approach as well as correlation analyses. We demonstrate, for the first time, interdependencies of neuronal processes relying on the immediate past. The reconfiguration of an action seems to overwrite immediately preceding processes. The analyses revealed modulations of theta (TBA), alpha (ABA) and beta band activity (BBA) in connection with fronto-temporal structures supporting the theoretical assumptions of the considered conceptual framework. The close interplay of attentional modulation by gating irrelevant information (ABA) and binding and retrieval processes (TBA) is reflected by the correlation of ABA in all pre-probe-intervals with post-probe TBA. Likewise, the role of BBA in maintaining the event file until retrieval is corroborated by BBA preceding the TBA-associated retrieval of perception-action codes. Following action execution, TBA shifted towards visual association cortices probably reflecting preparation for upcoming information, while ABA and BBA continue to reflect processes of attentional control and information selection for goal-directed behavior. The present work provides the first empirical support for concepts about the neurophysiological mechanisms of dynamic management of perception and action.
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Atención , Encéfalo , Humanos , Atención/fisiología , Corteza Cerebral , ElectroencefalografíaRESUMEN
BACKGROUND: The catecholaminergic system influences response inhibition, but the magnitude of the impact of catecholaminergic manipulation is heterogeneous. Theoretical considerations suggest that the voluntary modulability of theta band activity can explain this variance. The study aimed to investigate to what extent interindividual differences in catecholaminergic effects on response inhibition depend on voluntary theta band activity modulation. METHODS: A total of 67 healthy adults were tested in a randomized, double-blind, cross-over study design. At each appointment, they received a single dose of methylphenidate or placebo and performed a Go/Nogo task with stimuli of varying complexity. Before the first appointment, the individual's ability to modulate theta band activity was measured. Recorded EEG data were analyzed using temporal decomposition and multivariate pattern analysis. RESULTS: Methylphenidate effects and voluntary modulability of theta band activity showed an interactive effect on the false alarm rates of the different Nogo conditions. The multivariate pattern analysis revealed that methylphenidate effects interacted with voluntary modulability of theta band activity at a stimulus processing level, whereas during response selection methylphenidate effects interacted with the complexity of the Nogo condition. CONCLUSIONS: The findings reveal that the individual's theta band modulability affects the responsiveness of an individual's catecholaminergic system to pharmacological modulation. Thus, the impact of pharmacological manipulation of the catecholaminergic system on cognitive control most likely depends on the existing ability to self-modulate relevant brain oscillatory patterns underlying the cognitive processes being targeted by pharmacological modulations.
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Metilfenidato , Adulto , Humanos , Estudios Cruzados , Metilfenidato/farmacología , Encéfalo , Análisis Multivariante , Cognición , ElectroencefalografíaRESUMEN
The ability to inhibit an already initiated response is crucial for navigating the environment. However, it is unclear which characteristics make stop-signals more likely to be processed efficiently. In three consecutive studies, we demonstrate that stop-signal modality and location are key factors that influence reactive response inhibition. Study 1 shows that tactile stop-signals lead to better performance compared to visual stop-signals in an otherwise visual choice-reaction task. Results of Study 2 reveal that the location of the stop-signal matters. Specifically, if a visual stop-signal is presented at a different location compared to the visual go-signal, then stopping performance is enhanced. Extending these results, study 3 suggests that tactile stop-signals and location-distinct visual stop-signals retain their performance enhancing effect when visual distractors are presented at the location of the go-signal. In sum, these results confirm that stop-signal modality and location influence reactive response inhibition, even in the face of concurrent distractors. Future research may extend and generalize these findings to other cross-modal setups.
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Atención , Inhibición Psicológica , Humanos , Tiempo de Reacción/fisiología , Atención/fisiología , Desempeño Psicomotor/fisiologíaRESUMEN
Inhibitory control plays an indispensable role in cognitive flexibility. Nevertheless, the neurophysiological principles underlying this are incompletely understood. This owes to the fact that the representational dynamics, as coded in oscillatory neural activity of different frequency bands has not been considered until now-despite being of conceptual relevance. Moreover, it is unclear in how far distinct functional neuroanatomical regions are concomitantly involved in the processing of representational dynamics. We examine these questions using a combination of EEG methods. We show that theta-band activity plays an essential role for inhibitory control processes during cognitive flexibility across informational aspects coded in distinct fractions of the neurophysiological signal. It is shown that posterior parietal structures and the inferior parietal cortex seem to be the most important cortical region for inhibitory control processes during cognitive flexibility. Theta-band activity plays an essential role in processes of retrieving the previously inhibited representations related to the current task during cognitive flexibility. The representational content relevant for inhibitory processes during cognitive flexibility is coded in the theta frequency band. We outline how the observed neural mechanisms inform recent overarching cognitive frameworks on how flexible action control is accomplished.
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Cognición , Electroencefalografía , Cognición/fisiología , Lóbulo Parietal/fisiologíaRESUMEN
Representational momentum describes the typical overestimation of the final location of a moving stimulus in the direction of stimulus motion. While systematically observed in different sensory modalities, especially vision and audition, in touch, empirical findings indicate a mixed pattern of results, with some published studies suggesting the existence of the phenomenon, while others do not. In the present study, one possible moderating variable, the relative probabilities of different trial types, was explored in an attempt to resolve the seemingly contradictory findings in the literature. In some studies, only consistently moving target stimuli were presented and no representational momentum was observed, while other studies have included inconsistently moving target stimuli in the same experimental block, and observed representational momentum. Therefore, the present study was designed to systematically compare the localization of consistent target motion stimuli across two experimental blocks, for which either only consistent motion trials were presented, or else mixed with inconsistent target motion trials. The results indicate a strong influence of variations in the probability of different trial types on the occurrence of representational momentum. That is, representational momentum only occurred when both trial types (inconsistent and consistent target motion) were presented within one experimental block. The results are discussed in light of recent theoretical advancements in the literature, namely the speed prior account of motion perception.
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Percepción de Movimiento , Percepción del Tacto , Humanos , Percepción Auditiva , Movimiento (Física) , Tacto , Ensayos Clínicos como AsuntoRESUMEN
Recent studies have suggested that abstract control states (i.e., internal attentional states independent from concrete stimuli and responses) can be stored in episodic memory and retrieved subsequently. However, the duration of such a control state memory remains unclear. Previous research has found a quick and complete decay for stimulus-response bindings after 2000-5000 ms. Here, we tested a possible decay of control state bindings with retrieval delays of 2000, 3000, or 5000 ms. Five preregistered experiments used a confound-minimized prime-target task to measure the congruency sequence effect (CSE) separately for trials in which a nominally irrelevant context feature changed or repeated across trials. Analyses of the individual experiments did not result in conclusive evidence. A mega-analysis integrating the data of all experiments (Ntotal = 326) replicated evidence for binding and retrieval of control states, in that larger CSEs were found for context repetition trials. Importantly, Bayesian analysis indicated that this effect was not modulated by the length of retrieval delay. While this finding suggests that bindings of abstract control states can be relatively robust, we also discuss possible limitations of the present research.
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Atención , Memoria Episódica , Humanos , Tiempo de Reacción/fisiología , Teorema de Bayes , Atención/fisiología , Estimulación LuminosaRESUMEN
Interacting with our environment happens on different levels of complexity: While there are individual and simple actions like an isolated button press, most actions are more complex and involve sequences of simpler actions. The degree to which multiple simple actions are represented as one action sequence can be measured via so-called response-response binding effects. When two or more responses are executed consecutively, they are integrated into one representation so that repetition of one response can start retrieval of the other. Executing such an action sequence typically involves responding to multiple objects or stimuli. Here, we investigated whether the spatial relation of these stimuli affects action sequence execution. To that end, we varied the distance between stimuli in a response-response binding task. Stimulus distance might affect response-response binding effects in one of two ways: It might directly affect the representation of the response sequence, making integration and retrieval between responses more likely if the responses relate to close stimuli. Alternatively, the similarity of stimulus distribution during integration and retrieval might be decisive, leading to larger binding effects if stimulus distance is identical during integration and retrieval. We found stronger binding effects with constant than with changing stimulus distance, indicating that action integration and retrieval can easily affect performance also if responses refer to separated objects. However, this effect on performance is diminished by changing spatial distribution of stimuli at the times of integration and retrieval.
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Desempeño Psicomotor , Humanos , Femenino , Masculino , Adulto , Desempeño Psicomotor/fisiología , Adulto Joven , Percepción Espacial/fisiología , Tiempo de Reacción/fisiologíaRESUMEN
False memories during testimony are an enormous challenge for criminal trials. Exposure to post-event misinformation can lead to inadvertent creation of false memories, known as the misinformation effect. We investigated anodal transcranial direct current stimulation (tDCS) on the left inferior parietal lobe (IPL) during recall testing to enhance accurate recall while addressing the misinformation effect. Participants (N = 60) watched a television series depicting a fictional terrorist attack, then received an audio recording with misinformation, consistent information, and control information. During cued recall testing, participants received anodal or sham tDCS. Results revealed a robust misinformation effect in both groups, with participants falsely recalling on average 26.6% of the misinformed items. Bayesian statistics indicated substantial evidence in favour of the null hypothesis that there was no difference between groups in the misinformation effect. Regarding correct recall however, the anodal group exhibited significantly improved recall for items from the original video. Together, these results demonstrate that anodal tDCS of the left IPL enhances correct recall of the episodes from the original event without affecting false recall of misinformation. The findings support the IPL's role in recollection and source attribution of episodic memories.
RESUMEN
Evaluative Conditioning (EC) refers to changes in our liking or disliking of a stimulus due to its pairing with other positive or negative stimuli. In addition to stimulus-based mechanisms, recent research has shown that action-based mechanisms can also lead to EC effects. Research, based on action control theories, has shown that pairing a positive or negative action with a neutral stimulus results in EC effects (Stimulus-Response binding). Similarly, research studies using Operant Conditioning (OC) approaches have also observed EC effects. The aim of the present study is to directly compare EC effects elicited by two different response-based approaches - S-R bindings and OC. To this end, participants were randomly assigned to an S-R binding procedure and an OC procedure. EC effects were measured in conditions and compared. Implications for EC theory are discussed.
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Condicionamiento Operante , Humanos , Femenino , Masculino , Adulto Joven , Adulto , Condicionamiento PsicológicoRESUMEN
Target localization is influenced by the presence of additionally presented nontargets, termed landmarks. In both the visual and tactile modality, these landmarks led to systematic distortions of target localizations often resulting in a shift toward the landmark. This shift has been attributed to averaging the spatial memory of both stimuli. Crucially, everyday experiences often rely on multiple modalities, and multisensory research suggests that inputs from different senses are optimally integrated, not averaged, for accurate perception, resulting in more reliable perception of cross-modal compared with uni-modal stimuli. As this could also lead to a reduced influence of the landmark, we wanted to test whether landmark distortions would be reduced when presented in a different modality or whether landmark distortions were unaffected by the modalities presented. In two experiments (each n = 30) tactile or visual targets were paired with tactile or visual landmarks. Experiment 1 showed that targets were less shifted toward landmarks from the different than the same modality, which was more pronounced for tactile than for visual targets. Experiment 2 aimed to replicate this pattern with increased visual uncertainty to rule out that smaller localization shifts of visual targets due to low uncertainty had led to the results. Still, landmark modality influenced localization shifts for tactile but not visual targets. The data pattern for tactile targets is not in line with memory averaging but seems to reflect the effects of multisensory integration, whereas visual targets were less prone to landmark distortions and do not appear to benefit from multisensory integration.NEW & NOTEWORTHY In the present study, we directly tested the predictions of two different accounts, namely, spatial memory averaging and multisensory integration, concerning the degree of landmark distortions of targets across modalities. We showed that landmark distortions were reduced across modalities compared to distortions within modalities, which is in line with multisensory integration. Crucially, this pattern was more pronounced for tactile than for visual targets.
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Percepción del Tacto , Percepción Visual , Tacto , IncertidumbreRESUMEN
The human brain is in distinct processing modes at different times. Specifically, a distinction can be made between encoding and retrieval modes, which refer to the brain's state when it is storing new information or searching for old information, respectively. Recent research proposed the idea of a "ready-to-encode" mode, which describes a prestimulus effect in brain activity that signals (external) attention to encoding and predicts subsequent memory performance. Whether there is also a corresponding "ready-to-retrieve" mode in human brain activity is currently unclear. In this study, we examined whether prestimulus oscillations can be linked to (internal) attention to retrieval. We show that task cues to prepare for retrieval (or testing) in comparison with restudy of previously studied vocabulary word pairs led to a significant decrease of prestimulus alpha power just before the onset of word stimuli. Beamformer analysis localized this effect in the right secondary visual cortex (Brodmann area 18). Correlation analysis showed that the task cue-induced, prestimulus alpha power effect is positively related to stimulus-induced alpha/beta power, which in turn predicted participants' memory performance. The results are consistent with the idea that prestimulus alpha power signals internal attention to retrieval, which promotes the elaborative processing of episodic memories. Future research on brain-computer interfaces may find the findings interesting regarding the potential of using online measures of fluctuating alpha oscillations to trigger the presentation and sequencing of restudy and testing trials, ultimately enhancing instructional learning strategies.
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Encéfalo , Memoria Episódica , Humanos , Aprendizaje , Señales (Psicología) , Cognición , Ritmo alfa , ElectroencefalografíaRESUMEN
Inhibitory control processes have intensively been studied in cognitive science for the past decades. Even though the neural dynamics underlying these processes are increasingly better understood, a critical open question is how the representational dynamics of the inhibitory control processes are modulated when engaging in response inhibition in a relatively automatic or a controlled mode. Against the background of an overarching theory of perception-action integration, we combine temporal and spatial EEG signal decomposition methods with multivariate pattern analysis and source localization to obtain fine-grained insights into the neural dynamics of the representational content of response inhibition. For this purpose, we used a sample of N = 40 healthy adult participants. The behavioural data suggest that response inhibition was better in a more controlled than a more automated response execution mode. Regarding neural dynamics, effects of response inhibition modes relied on a concomitant coding of stimulus-related information and rules of how stimulus information is related to the appropriate motor programme. Crucially, these fractions of information, which are encoded at the same time in the neurophysiological signal, are based on two independent spatial neurophysiological activity patterns, also showing differences in the temporal stability of the representational content. Source localizations revealed that the precuneus and inferior parietal cortex regions are more relevant than prefrontal areas for the representation of stimulus-response selection codes. We provide a blueprint how a concatenation of EEG signal analysis methods, capturing distinct aspects of neural dynamics, can be connected to cognitive science theory on the importance of representations in action control.
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Electroencefalografía , Desempeño Psicomotor , Adulto , Humanos , Desempeño Psicomotor/fisiología , Lóbulo Parietal/diagnóstico por imagen , Lóbulo Parietal/fisiologíaRESUMEN
BACKGROUND: Although functional neurological movement disorders (FMD) are characterized by motor symptoms, sensory processing has also been shown to be disturbed. However, how the integration of perception and motor processes, essential for the control of goal-directed behavior, is altered in patients with FMD is less clear. A detailed investigation of these processes is crucial to foster a better understanding of the pathophysiology of FMD and can systematically be achieved in the framework of the theory of event coding (TEC). OBJECTIVE: The aim was to investigate perception-action integration processes on a behavioral and neurophysiological level in patients with FMD. METHODS: A total of 21 patients and 21 controls were investigated with a TEC-related task, including concomitant electroencephalogram (EEG) recording. We focused on EEG correlates established to reflect perception-action integration processes. Temporal decomposition allowed to distinguish between EEG codes reflecting sensory (S-cluster), motor (R-cluster), and integrated sensory-motor processing (C-cluster). We also applied source localization analyses. RESULTS: Behaviorally, patients revealed stronger binding between perception and action, as evidenced by difficulties in reconfiguring previously established stimulus-response associations. Such hyperbinding was paralleled by a modulation of neuronal activity clusters, including reduced C-cluster modulations of the inferior parietal cortex and altered R-cluster modulations in the inferior frontal gyrus. Correlations of these modulations with symptom severity were also evident. CONCLUSIONS: Our study shows that FMD is characterized by altered integration of sensory information with motor processes. Relations between clinical severity and both behavioral performance and neurophysiological abnormalities indicate that perception-action integration processes are central and a promising concept for the understanding of FMD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Trastornos de Conversión , Trastornos del Movimiento , Humanos , Electroencefalografía , Lóbulo Parietal , Movimiento/fisiología , PercepciónRESUMEN
BACKGROUND: Video-based tic detection and scoring is useful to independently and objectively assess tic frequency and severity in patients with Tourette syndrome. In trained raters, interrater reliability is good. However, video ratings are time-consuming and cumbersome, particularly in large-scale studies. Therefore, we developed two machine learning (ML) algorithms for automatic tic detection. OBJECTIVE: The aim of this study was to evaluate the performances of state-of-the-art ML approaches for automatic video-based tic detection in patients with Tourette syndrome. METHODS: We used 64 videos of n = 35 patients with Tourette syndrome. The data of six subjects (15 videos with ratings) were used as a validation set for hyperparameter optimization. For the binary classification task to distinguish between tic and no-tic segments, we established two different supervised learning approaches. First, we manually extracted features based on landmarks, which served as input for a Random Forest classifier (Random Forest). Second, a fully automated deep learning approach was used, where regions of interest in video snippets were input to a convolutional neural network (deep neural network). RESULTS: Tic detection F1 scores (and accuracy) were 82.0% (88.4%) in the Random Forest and 79.5% (88.5%) in the deep neural network approach. CONCLUSIONS: ML algorithms for automatic tic detection based on video recordings are feasible and reliable and could thus become a valuable assessment tool, for example, for objective tic measurements in clinical trials. ML algorithms might also be useful for the differential diagnosis of tics. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Trastornos de Tic , Tics , Síndrome de Tourette , Humanos , Tics/diagnóstico , Síndrome de Tourette/diagnóstico , Reproducibilidad de los Resultados , Trastornos de Tic/diagnóstico , Aprendizaje AutomáticoRESUMEN
Processing ambiguous situations is a constant challenge in everyday life and sensory input from different modalities needs to be integrated to form a coherent mental representation on the environment. The bouncing/streaming illusion can be studied to provide insights into the ambiguous perception and processing of multi-modal environments. In short, the likelihood of reporting bouncing rather than streaming impressions increases when a sound coincides with the moment of overlap between two moving disks. Neuroimaging studies revealed that the right posterior parietal cortex is crucial in cross-modal integration and is active during the bouncing/streaming illusion. Consequently, in the present study, we used transcranial direct current stimulation to stimulate this brain area. In the active stimulation conditions, a 9 cm2 electrode was positioned over the P4-EEG position and the 35 cm2 reference positioned over the left upper arm. The stimulation lasted 15 min. Each participant did the bouncing/streaming task three times: before, during and after anodal or sham stimulation. In a sample of N = 60 healthy, young adults, we found no influence of anodal tDCS. Bayesian analysis showed strong evidence against tDCS effects. There are two possible explanations for the finding that anodal tDCS over perceptual areas did not modulate multimodal integration. First, upregulation of multimodal integration is not possible using tDCS over the PPC as the integration process already functions at maximum capacity. Second, prefrontal decision-making areas may have overruled any modulated input from the PPC as it may not have matched their decision-making criterion and compensated for the modulation.
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Ilusiones , Estimulación Transcraneal de Corriente Directa , Adulto Joven , Humanos , Estimulación Transcraneal de Corriente Directa/métodos , Teorema de Bayes , Encéfalo/fisiología , Lóbulo Parietal/fisiologíaRESUMEN
Even simple actions like opening a door require integration/binding and flexible reactivation of different motor elements. Yet, the neural mechanisms underlying the processing of such "embedded response plans" are largely elusive, despite theoretical frameworks, such as the theory of event coding, describing the involved cognitive processes. In a sample of n = 40 healthy participants, we combine time-frequency decomposition and various beamforming methods to examine the neurophysiological dynamics of such action plans, with special emphasis on the interplay of theta and beta frequency activity during the processing of these plans. We show that the integration and rule-guided reactivation of embedded response plans is modulated by a complex interplay of theta and beta activity. Pretrial beta-band activity (BBA) is related to different functional neuroanatomical structures that are activated in a consecutive fashion. Enhanced preparatory activity is positively associated with higher binding-related BBA in the precuneus/parietal areas, indicating that activity in the precuneus/parietal cortex facilitates the execution of an embedded action sequence. Increased preparation subsequently leads to reduced working memory retrieval demands. A cascading pattern of interactions between pretrial and within-trial activity indicates the importance of preparatory brain activity. The study shows that there are multiple roles of beta and theta oscillations associated with different functional neuroanatomical structures during the integration and reactivation of motor elements during actions.NEW & NOTEWORTHY Even simple actions like opening a door require integration/binding and flexible reactivation of different motor elements. Yet, the neural mechanisms underlying the processing of such "embedded response plans" are largely elusive. The study shows that there are multiple roles of beta and theta oscillations associated with different functional neuroanatomical structures during the integration and reactivation of motor elements during actions.
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Ritmo beta , Lóbulo Frontal , Lóbulo Parietal , Desempeño Psicomotor , Ritmo Teta , Ritmo beta/fisiología , Electroencefalografía , Lóbulo Frontal/fisiología , Humanos , Memoria a Corto Plazo/fisiología , Lóbulo Parietal/fisiología , Desempeño Psicomotor/fisiología , Ritmo Teta/fisiologíaRESUMEN
Human action control relies on event files, that is, short-term stimulus-response bindings that result from the integration of perception and action. The present EEG study examined oscillatory brain activities related to the integration and disintegration of event files in the distractor-response binding (DRB) task, which relies on a sequential prime-probe structure with orthogonal variation of distractor and response relations between prime and probe. Behavioral results indicated a DRB effect in RTs, which was moderated by the duration of the response-stimulus interval (RSI) between prime response and probe stimulus onset. Indeed, a DRB effect was observed for a short RSI of 500 msec but not for a longer RSI of 2000 msec, indicating disintegration of event files over time. EEG results revealed a positive correlation between individual DRB in the RSI-2000 condition and postmovement beta synchronization after both prime and probe responses. Beamformer analysis localized this correlation effect to the middle occipital gyrus, which also showed highest coherency with precentral and inferior parietal brain regions. Together, these findings suggest that postmovement beta synchronization is a marker of event file disintegration, with the left middle occipital gyrus being a hub region for stimulus-response bindings in the visual DRB task.