RESUMEN
Trophic factors are naturally produced by different tissues that participate in several functions such as the intercellular communication, in the development, stability, differentiation and regeneration at the cellular level. Specifically, in the case of spinal injuries, these factors can stimulate neuronal recovery. They are applied both in experimental models and in clinical trials in patients. The trophic factors analysed in this review include gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), growth hormone (GH), melatonin, oestrogens, the family of fibroblast growth factors (FGFs), the family of neurotrophins and the glial cell-derived neurotrophic factor (GDNF). There are some trophic (neurotrophic) factors that already been tested in patients with spinal cord injury (SCI), but only shown partial recovery effect. It is possible that, the administration of these trophic factors together with physical rehabilitation, act synergistically and, therefore, significantly improve the quality of life of patients with SCI.
Asunto(s)
Factores de Crecimiento Nervioso/metabolismo , Traumatismos de la Médula Espinal/tratamiento farmacológico , Regeneración de la Medula Espinal , Animales , Humanos , Factores de Crecimiento Nervioso/uso terapéutico , Médula Espinal/metabolismo , Médula Espinal/fisiologíaRESUMEN
The bioequivalence of three different commercial diazepan tablets (5mg) using the innovator product (Valium, Roche) as a reference was evaluated in eight psychiatric patients, following a multiple-dose regimen (5 mg t.i.d.). Each patient receive the four treatments sequentially according to a Latin square design, with balance for first residual effect. Blood samples were taken once the steady state of the drug had been reached, and the plasma levels were determined using a HPLC method. No statistical differences were found in diazepam steady-state levels after the adminsitration of the four formulations, indicating that they could be aconsidered equivalent
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Diazepam/uso terapéutico , Psiquiatría , Equivalencia Terapéutica , Volumen Plasmático , Volumen Plasmático/fisiologíaRESUMEN
Acualmente el diagnóstico predictivo de la enfermedad de Huntington (EH) se efectúa por medio de un equipo multidisciplinario. El psiquiatra es importante durante la evaluación de los candidatos que desean que se les realice el diagnóstico predictivo para la EH. Ya que pueden presentarse diversos problemas psiquiátricos por el hecho de saberse en riesgo, y posteriormente al recibir el resultado. La adaptación al resultado sea este positivo o negativo es difícil. Este artículo describe la experiencia psiquiátrica obtenida en nuestra investigación en el Instituto Nacional de Neurología y Neurocirugía de México