Decoding natural scenes based on sounds of objects within scenes using multivariate pattern analysis.

Scene recognition plays an important role in spatial navigation and scene classification. It remains unknown whether the occipitotemporal cortex could represent the semantic association between the scenes and sounds of objects within the scenes. In this study, we used the functional magnetic resonance imaging (fMRI) technique and multivariate pattern analysis to assess whether diff ; ;erent scenes could be discriminated based on the patterns evoked by sounds of objects within the scenes. We found that patterns evoked by scenes could be predicted with patterns evoked by sounds of objects within the scenes in the posterior fusiform area (pF), lateral occipital area (LO) and superior temporal sulcus (STS). The further functional connectivity analysis suggested significant correlations between pF, LO and parahippocampal place area (PPA) except that between STS and other three regions under the scene and sound conditions. A distinct network in processing scenes and sounds was discovered using a seed-to-voxel analysis with STS as the seed. This study may provide a cross-modal channel of scene decoding through the sounds of objects within the scenes in the occipitotemporal cortex, which could complement the single-modal channel of scene decoding based on the global scene properties or objects within the scenes.

Abdominal cocoon accompanied by multiple peritoneal loose body.

RATIONALE: Abdominal cocoon and peritoneal loose body are both rare abdominal diseases. PATIENT CONCERNS: The patient reported in this case was a 47-year-old man who suffered from abdominal pain and distension for 3 days. DIAGNOSIS: X-ray, computed tomography, and magnetic resonance imaging revealed multiple peritoneal loose body and small bowel obstruction, characterized by a total encapsulation of the small bowel with a fibrous membrane. INTERVENTIONS: The patient underwent surgical treatment and exploratory laparotomy confirmed the diagnosis of abdominal cocoon. OUTCOMES: Histopathological examination of pelvic nodules confirmed peritoneal loose body. LESSONS: To our knowledge, the herein reported case is the first abdominal cocoon that was accompanied by multiple peritoneal loose body.

Malignant perivascular epithelioid cell tumor arising in the mesentery: A case report.

Primary perivascular epithelioid cell tumors (PEComas) of the mesentery are rare; therefore, the clinical and imaging features of the tumor have yet to be adequately investigated. The present study reports the case of a 48-year-old female patient histologically diagnosed with a PEComa arising in the mesentery of the small bowel. Abdominal plain computed tomography (CT) identified a large, partially ill-defined and heterogeneous mass with a size of 12.5×8.5-cm occupying the lower abdomen. Upon contrast-enhanced CT imaging, the tumor displayed nonhomogeneous contrast-enhancement with hypodense areas, and multiple tumor vessels were observed during arterial phase imaging. In conclusion, the present study proposed that PEComas should be considered in the differential diagnosis of lesions arising in the mesentery; however, differentiation based on imaging criteria alone can be difficult.

MRI and MR spectroscopy findings of the evolution of an intracranial germinoma: A case report.

Intracranial germinomas (IG) are rare tumors that typically occur in the pineal gland and suprasellar region of the brain. IG can be successfully treated with radiation therapy and its recurrence is rare. The present study reports the case of a patient with IG involving the pineal and suprasellar regions. The patient was treated with radiotherapy, achieving significant remission. However, recurrence was discovered 10 months later. The patient was subsequently treated with chemotherapy and radiotherapy, resulting in gradual remission. The patient had recovered 2 months later and was in good health. The entire evolution process, including magnetic resonance (MR) imaging and MR spectroscopy findings, are described herein. The present case suggests that MR spectroscopy may be useful for monitoring the effects of treatment.

Multiple mesenteric well-differentiated liposarcoma complicated by purulent inflammation: A case report.

Multiple mesenteric well-differentiated (WD) liposarcoma is an extremely rare entity. The present study describes a case of multiple mesenteric WD liposarcoma, complicated by purulent inflammation, in a 59-year-old male who presented with abdominal pain and pyrexia of unknown origin. A computed tomography scan of the abdomen revealed a large, non-encapsulated mass in the abdomino-pelvic cavity, which was characterized by two components, a main portion of fatty density and a non-adipose solid portion. A re-evaluated CT scan, performed eight days later, revealed an enlargement of the non-adipose mass. A laparotomy was performed, and numerous separated fatty nodules and masses of various sizes were identified within the mesentery of the small intestine. The histological findings were consistent with an adipocytic subtype of multiple mesenteric WD liposarcoma, with the largest of the tumors complicated by purulent inflammation. The multiplicity of these tumors and the concurrent purulent inflammation in the present case make it unique.

EGFR mutation L747P led to gefitinib resistance and accelerated liver metastases in a Chinese patient with lung adenocarcinoma.

BACKGROUND: Mutations in the epidermal growth factor receptor gene (EGFR) are found in around half of Asian patients with non-small cell lung cancer (NSCLC). For this reason, EGFR tyrosine kinase inhibitors (TKI) are often prescribed depending on the EGFR status. Two common EGFR mutations, a deletion in exon 19 and L858R in exon 21, demonstrate a positive response to gefitinib, the first approved EGFR TKI. However, T790M and an insertion in EGFR exon 21 are resistant to EGFR TKI treatment. The relationships between the EGFR mutation type and response to the target drug have not been fully investigated. CASE PRESENTATION: We describe a 66-year-old Chinese male diagnosed with stage IV lung adenocarcinoma based on evidence from a computed tomography (CT) scan and histological features of a biopsy taken during fiberoptic bronchoscopy surgery. Molecular analysis of EGFR exons 19 and 21 revealed the presence of only one mutation in exon 19: L747P (2239-2240 TT>CC). The patient requested gefitinib treatment for 2 weeks but his response was poor. A CT scan revealed that the number and relative volume of the liver metastases had increased after treatment. CONCLUSION: L747P (2239-2240 TT>CC) in exon 19 is a rare EGFR mutation that appears to lead to gefitinib resistance and might accelerate liver metastases.

Primary clear cell adenocarcinoma of the colon presenting as a huge extracolic mass: A case report.

A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. The current study presents a case of such a tumor in the transverse colon of a 26-year-old male, and describes the computed tomography features of the neoplasm. The tumor appeared as an extensive extracolic mass, which displaced the loop of the small bowel and pancreas, and invaded the spleen. A laparotomy was performed and a huge mass measuring 12 cm maximally was revealed, arising from the transverse colon close to the left colonic flexure, with invasion of the spleen. The tumor and the spleen were resected concurrently. Histopathological examination of the excised mass revealed features of clear cell adenocarcinoma. A primary clear cell adenocarcinoma of the colon is a rare tumor, with only 13 cases reported in the English literature at present. The present case is reported here due to its rarity.

Aggressive angiomyxoma: an unusual presentation.

Aggressive angiomyxoma is an uncommon mesenchymal myxoid tumor that is characterized by slow growth and frequent local recurrence. It is currently regarded as a nonmetastasizing tumor. We describe a case of recurrent aggressive angiomyxoma with invasion into the veins including the inferior vena cava and the right atrium and with pulmonary metastases. Our case, together with those unusual cases documented in previous reports, may lead to a reappraisal of the nature of aggressive angiomyxoma.

Large paravaginal angiomyofibroblastoma: magnetic resonance imaging findings.

Angiomyofibroblastoma (AMFB) is a rare, benign, mesenchymal tumor that occurs mainly in the female lower genital tract. We report on a large posterior paravaginal AMFB that presented as a buttock mass, describing the magnetic resonance imaging (MRI) features of the disease. The tumor displays heterogeneous signal intensity on T2-weighted MRI and fast and persistent inhomogeneous enhancement on dynamic gadolinium-enhanced MRI.