RESUMEN
Chronic non-infectious diseases are important to research as they are the main causes of death in Brazil and worldwide. One very important chronic non-infectious disease is cardiovascular disease, whose risk factors (diabetes, dyslipidemia, and renal failure) can be detected through assessments of serum biochemical components. The objective of this study was to evaluate the analytical performance of Raman spectroscopy for analysis of lipid profile (total cholesterol, triglycerides, and HDL cholesterol), non-protein nitrogenous compounds (urea and creatinine), and glucose in 242 human serum samples. Models to discriminate and quantify the samples were developed using the predicted concentration by quantitative regression model based on partial least squares (PLS). The analytical error for the "leave-one-out" cross-validation based on the predicted PLS concentration was 10.5 mg/dL for total cholesterol, 21.4 mg/dL for triglyceride, 13.0 mg/dL for HDL cholesterol, 4.9 mg/dL for urea, 0.21 mg/dL for creatinine, and 15.4 mg/dL for glucose. The Kappa coefficient indicate very good agreement for cholesterol (0.83), good for triglyceride (0.77), urea (0.70) and creatinine (0.66), and fair for HDL cholesterol (0.38) and glucose (0.30). The results of the analytical performance demonstrated that Raman spectroscopy can be considered an important methodology to screen the population, especially for serum triglycerides and cholesterol.
Asunto(s)
Colesterol , Espectrometría Raman , Humanos , Análisis de los Mínimos Cuadrados , Suero , TriglicéridosRESUMEN
Objetivo: identificar os números de acidentes por animais peçonhentos em Tangará da Serra nos últimos 10 anos. Método: estudo transversal, descritivo e retrospectivo pautado em dados do Sistema de Informação de Agravos de Notificação, analisando os acidentes entre os anos de 2007 e 2016. Resultados: foram analisados 441 casos notificados no Sistema de Informação de Agravos de Notificação (SINAN) no período de 2007 a 2016, com predomínio de pessoas do sexo masculino (67,57%), com idade inferior a 20 anos (22,45%), por acidentes ofídicos (60,3%), entre os meses de fevereiro a maio (44,89%), tempo decorrido médio entre a picada e o atendimento foi de 2 horas, evolução clínica do caso para cura (99,77%). Conclusão: Tangará da Serra registra um número importante de acidentes com animais peçonhentos sendo primordial a manutenção de ações que estimulem as notificações e o tratamento precoce prevenindo assim as sequelas e óbitos.
Objective: to identify the numbers of accidents by venomous animals in Tangará da Serra in the last 10 years. Method: a cross-sectional, descriptive and retrospective study based on data from the Notifiable Diseases Information System, analyzing accidents between 2007 and 2016. Results: a total of 441 cases reported in the SINAN reporting system were analyzed. Between 2007 and 2016, with a predominance of male individuals (67,57%), aged less than 20 years (22.45%), due to ophidian accidents (60.3%), between February and May (44,89%), mean time elapsed between the sting and the care was 2 hours, clinical evolution of the case for cure (99.77%). Conclusion: Tangará da Serra recorded a significant number of accidents with venomous animals, and it is essential to maintain actions that stimulate early notification and treatment, thus preventing sequelae and death.
Objetivo: identificar los animales por el número de accidentes venenosas en Tangara da Serra en los últimos 10 años. Método: estudio transversal, descriptivo y retrospectivo guiada por los datos de las enfermedades de declaración obligatoria del sistema de información, el análisis de los accidentes entre 2007 y 2016. Resultados: se analizaron 441 casos reportados en las enfermedades de declaración obligatoria Sistema de Información (SINAN) en periodo 2007-2016, con un predominio del sexo masculino (67,57%), edad inferior a 20 años (22,45%), por mordeduras de serpientes (60,3%), entre los meses de febrero a mayo (44,89%), el tiempo medio transcurrido entre la mordedura y el servicio fue de 2 horas, evolución clínica para curar (99,77%). Conclusión: Tangara da Serra registra un gran número de accidentes con animales venenosos y acciones de mantenimiento primarias que fomentan las notificaciones y el tratamiento precoz evitando así las secuelas y la muerte.