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1.
Opt Lett ; 45(10): 2788-2791, 2020 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-32412467

RESUMEN

An actively Q-switched mid-infrared Fe:ZnSe laser pumped by a continuous wave fluoride fiber laser has been developed. Stable operation with a pulse duration of 20 ns and a repetition rate of 40 kHz at 4 µm was achieved. The maximum peak power was 1.1 kW. The high-repetition rate, high-peak power nanosecond pulsed laser, which has been created for the first time, to the best of our knowledge, in an actively Q-switched Fe:ZnSe laser, should prove a suitable light source for laser processing and molecular sensing.

2.
Opt Lett ; 44(19): 4777-4780, 2019 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-31568440

RESUMEN

A fluoride-fiber-based master oscillator power amplifier (MOPA) for 30-W class continuous-wave (cw) operation at 2.8-µm wavelength has been demonstrated. To overcome the low durability of ZBLAN fibers, various novel technologies for using fluoride glass with a ZBLAN-fiber-based side-pump combiner have been adopted in the system. A maximum cw output power of 33 W and stable operation under 23-W output have been demonstrated. We suggest that such fiber MOPA systems will open up advanced fluoride fiber technology for next-generation high-power mid-IR lasers.

3.
Opt Express ; 26(25): 33305-33313, 2018 Dec 10.
Artículo en Inglés | MEDLINE | ID: mdl-30645484

RESUMEN

We report the femtosecond laser inscription of fiber Bragg gratings (FBGs) in an Er-doped fluoride glass fiber used for lasing at a mid-infrared wavelength of 2.8 µm. The lasing evolution is discussed in terms of the FBG reflectivity, wavelength transition to the Bragg wavelength, and output power of the mid-infrared fiber laser. A first-order and short (2.5-mm-long) Bragg grating showed a reflectivity of 97%, because of a laser-induced index modulation of 1.1 × 10-3. This modulation was sufficient to saturate this system's output power. The laser oscillator is designed to lase in the atmospheric window of 2799-2800 nm slope. Further, this oscillator's efficiency is as high as 29.1% for the launched pump power over the range of 0.4-4.6 W and at a lasing wavelength of 2799.7 nm. This oscillator also exhibited a FWHM bandwidth of 0.12 nm.

4.
Sci Rep ; 11(1): 5432, 2021 Mar 08.
Artículo en Inglés | MEDLINE | ID: mdl-33686156

RESUMEN

Er3+/Dy3+ co-doped double-clad ZBLAN optical fiber has been used to obtain amplified spontaneous emission (ASE) broadband light sources cladding-pumped by 980-nm multimode laser diode (LD) sources. It has been demonstrated that mid-infrared broadband emission extending from 2515 to 3735 nm was obtained by energy transfer between Er3+ and Dy3+. We experimentally investigated the optimum design of Er3+/Dy3+ co-doped ZBLAN fiber in terms of ion concentration, fiber length, pumping configuration, and pumping power. The ASE output power was more than 2.5 mW when the LD pump power was set at 5 W. To assess its potential for gas sensing applications, the fabricated ASE light source was used to successfully detect methane gas with concentrations at 1% and 5%. The simple and stable construction of our ASE light source is suitable for practical purposes.

5.
Anal Sci ; 34(1): 33-38, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29321454

RESUMEN

In this study, we demonstrate the precise control of fluid flow using femtosecond (FS) laser-induced microstructures. A microgroove structure inscribed on a poly(methyl methacrylate) (PMMA) substrate functions as a superhydrophilic membrane similar to paper. We first estimated the flow rate for pure water on microgrooves fabricated at various laser fluences in the range from 9.2 to 100.8 J/cm2. The results showed that the flow rate could be tuned in the range from 0.30 to 12.07 µL/s by varying the laser irradiation parameters. The fluid flow was reproducible, with a calculated relative standard deviation (RSD%) of less than 8% in the flow rate. We then fabricated a microfilter for blood separation and estimated its filtration ability using artificial blood containing resin microparticles. This method would be useful in a technology related to a paper-based diagnostic device for precise reagent manipulation.

6.
Anal Sci ; 34(1): 57-63, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29321459

RESUMEN

Although paper-based microfluidic devices are an ideal platform for point-of-care (POC) diagnostics, it is difficult to achieve microfluidic control required for sensitive analyses such as ELISA on a paper substrate. Here, we present a novel lateral-flow test chip that can perform operations similar to a pump, such as flowing, stopping, and replacing a solution, just by adding the solution onto an inlet port. The chip was fabricated by laminating paper, film, and adhesive tape. For sensitive and accurate detection in an immunoassay, the transparency and flatness of the substrate is crucial for precise analysis of weak light generated by a specific antigen-antibody reaction; however, paper is not flat and is opaque. Therefore, transparent film was applied to the detection area of the chip in this study. The chip showed a good correlation at 0.1 - 100 ng ml-1 concentrations of C-reactive protein, demonstrating high quantitative analysis of CRP in serum suitable for clinical trials. The signal intensity of the novel chip was higher than that of a chip made of nitrocellulose membrane, and the variation was smaller. The limit of detection of the chip was 0.1 ng ml-1, whereas that of the nitrocellulose membrane was 100 ng ml-1. This novel chip can be used for sensitive sandwich immunoassays just by adding solutions.


Asunto(s)
Inmunoensayo/instrumentación , Dispositivos Laboratorio en un Chip , Animales , Colodión/química , Humanos , Membranas Artificiales , Sistemas de Atención de Punto
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