Which Histometric Analysis Approach Is More Reliable for Assessing Histological Bone Tissue Samples?

This study aims to evaluate the grid of Merz and ImageJ methods for histometric quantification, verifying which is more reliable and defining which is most suitable based on the time required to perform. Thirty histological samples of maxillary sinuses grafted with xenografts were evaluated using an optical light microscope attached to an image capture camera and connected to a microcomputer. The images were digitalized and recorded as a TIFF image, and the new bone formation was evaluated using the grid of Merz and ImageJ. The Bland-Altman analysis was used to identify the agreement between the methods and determine suitable future research options. The timing of the quantification was also performed to identify a possible advantage. The mean value for the quantification analysis timing for the grid of Merz was 194.9 ± 72.0 s and for ImageJ was 871.7 ± 264.4, with statistical significance between the groups (p = 0.0001). The Bland-Altman analysis demonstrated a concordance between the methods, due to the bias being next to the maximum concordance (-1.25) in addition to the graphic showing the scattering points next to the mean of differences and inside of limits of agreement. Thus, it was demonstrated that the grid of Merz presents reliable outcomes and advantages over the ImageJ methodology regarding the time spent to contour the areas of interest.

Temporal Muscle Flap as a Treatment of an Extensive Cleft Palate in an Adult Patient.

For the management of cleft palate, the surgical approach has been suggested at an early stage even in childhood, varying in the number of interventions. Once the interventions are not performed at appropriate times, such as sequences that may accompany specific psychological, functional, and aesthetic effects. Since it has been indicated, temporal muscle flap is a technique with satisfactory results for a resolution of extensive clef palate in adult patients. The purpose of this paper is reporting a case of temporal muscle flap in the soft and hard palate of an adult with a reconstruction of the donor area with a titanium mesh. A 37 year old male patient with cleft lip/palate, complained of difficulty in speech, chewing, swallowing, and breathing. Clinically, it was observed oroantral communication in the region of the hard and soft palate, with a previous cheiloplasty. A temporal rotation was planned to close the fissure for the treatment. The modified coronal approach was used. Temporal muscle traction and its interposition in the palate region were performed through the tunneling technique, and mass suturing was performed. After 3 years, he presented satisfactory results, with the improvement of the quality of life, as well as the area of exposure. In conclusion, since it has been indicated, temporal muscle flap is a technique with satisfactory results for a resolution of extensive cleft palate in adult patients.

Prospective and Randomized Evaluation of ChronOS and Bio-Oss in Human Maxillary Sinuses: Histomorphometric and Immunohistochemical Assignment for Runx 2, Vascular Endothelial Growth Factor, and Osteocalcin.

PURPOSE: The aim of this study was to compare ChronOS (ß-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1:1 ratio in human maxillary sinus bone augmentation. MATERIALS AND METHODS: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1:1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1:1 ratio. The number of samples for each group was determined by the statistical power test. RESULTS: The median areas of new bone formation in groups 1, 2, 3, 4, and 5 were 121,917.0, 83,787.0, 99,295.0, 65,717.0, and 56,230.0 µm2, respectively. Statistically significant differences were found between groups 3 and 5, groups 1 and 4, and groups 1 and 5 (P < .05). The median areas of remaining biomaterial were 2,900.5, 5,291.0, 2,662.0, 56,258.5, and 64,753.5 µm2 in groups 1, 2, 3, 4 and 5, respectively. Statistically significant differences occurred between groups 1 and 5, groups 3 and 5, and groups 2 and 5 (P < .05). Areas of connective tissue were 67,829.0 ± 22,984.6 µm2 in group 1, 97,445.9 ± 18,983.3 µm2 in group 2, 88,256.0 ± 21,820.5 µm2 in group 3, 65,501.8 ± 6,297.6 in group 4, and 70,203.2 ± 13,421.3 µm2 in group 5. CONCLUSIONS: ChronOS combined with autogenous bone graft presented a behavior similar to that of autogenous bone graft alone. However, the groups treated with Bio-Oss showed immuno-labeling results indicating maturation of grafted bone.

Reduction and fixation of mandibular condylar fractures with neck screw.

PURPOSE: The purpose of the present study is to describe a surgical technique for the treatment of condylar fractures using an intramedullary screw. MATERIALS AND METHODS: The treatment of these fractures remains very controversial. At the time of the choice of the surgical treatment, a wide range of accesses and of techniques of reduction and fixation is used, depending on the type of the fracture, the experience of the surgeon, and aesthetical issues. Among the difficulties posed by this type of fracture is the correct repositioning of the fractured condylar portion for which we have developed a technique that uses a neck screw, with intramedullary insertion. Because this is a round-headed screw, it is necessary to install a plate, which may be straight or "L" shape, and is placed perpendicular and superjacent to the screw so that it does not allow the rotation of the condylar portion. RESULTS: Neck screw can be used, resulting in satisfactory stability, for the reduction and fixation of these fractures.

The Role of Computed Tomography in Zygomatic Bone Fracture - A Case Report.

INTRODUCTION: The zygomatic complex is integral to the facial contour, protection of the eye and other facial structures, and dental occlusion. Its importance in facial function and aesthetics requires high quality outcomes of the treatment. CASE PRESENTATION: This paper reports the case of a 46-year-old man who had an occupational accident resulting in extensive facial trauma and zygomatic fractures. The patient presented with hyposphagma, palpable step in the area of the infraorbital rim, paresthesia of the right infraorbital nerve, flattening of zygomatic prominence, abrasion of the chin and nose, a 7-cm laceration in the midface region, ecchymosis in the palate, and alteration in the dental occlusion without limitation of mouth opening. Computed tomography (CT) confirmed the zygomatic complex fractures. The treatment was reduction and fixation with plates and screws. CT was used throughout the treatment period as an essential diagnostic tool for accurate fracture assessment and classification, formulation of the surgical plan, and postoperative evaluation. CONCLUSION: This case study illustrated the correct use of CT for improved and efficient treatment of traumatic injury of the zygoma, an anatomical area where restoration of function and aesthetics is challenging. The patient signed a written informed consent statement for publication.

The new bone formation in human maxillary sinuses using two bone substitutes with different resorption types associated or not with autogenous bone graft: a comparative histomorphometric, immunohistochemical and randomized clinical study.

OBJECTIVE: The aim of this study is to evaluate the new bone and connective tissue formation and the biomaterial remaining after maxillary sinus bone augmentation using 5 different bone substitutes. The osteocalcin immunolabeling was performed to demonstrate their calcification and the possibility of receiving dental implants. METHODOLOGY: 40 patients underwent maxillary sinus bone augmentation and were divided in 5 groups: Group 1 with 8 maxillary sinuses were grafted with autogenous bone graft (AB); Group 2 with 8 maxillary sinuses grafted with bioactive glass (BG); Group 3 with 8 maxillary sinuses grafted with bioactive glass added to autogenous bone graft (BG + AB) 1:1; Group 4 with 8 maxillary sinuses grafted with Bio-Oss (BO) and Group 5 with 8 maxillary sinuses grafted with Bio-Oss added to autogenous bone graft (BO + AB) 1:1. RESULTS: In group AB, 37.8% of bone was formed in the pristine bone region, 38.1% in the intermediate and 44.5% in the apical region. In group BG, 43.6% was formed in the pristine bone, 37% in the intermediate and 49.3% in the apical region. In group BG + AB 1:1, 39.0% was formed in the pristine bone region, 34.8% in the intermediate and 36.8% in apical region. In group BO, 33.4% was formed in the pristine bone, 32.5% in the intermediate and 34.3% in the apical region. In group BO + AB 1:1, 32.8% was formed in the pristine bone, 36.1% in intermediate and 27.8% in the apical regions. The immunolabeling for osteocalcin showed an intensive staining for all groups, which could demonstrate the calcification of the bone formed. CONCLUSION: This study showed that the groups evaluated formed a suitable lamellar bone in the maxillary sinus reconstruction after six months of bone healing, thus being indicated to receive dental implants.

Prospective evaluation of morbidity in patients who underwent autogenous bone-graft harvesting from the mandibular symphysis and retromolar regions.

BACKGROUND: Autogenous bone grafts are the most favorable and predictable types of bone graft due to their osteogenic, osteoinductive, and osteoconductive properties. The advantages of harvesting from mandibular bone are that it requires only local anesthesia, is less invasive, has less morbidity, and avoids harvesting from distant sites, thus making it the best choice for maxillary bone reconstruction. PURPOSE: The aim of this study was to evaluate inferior alveolar nerve (IAN) neurosensory disturbances after autogenous bone graft harvesting from the mandibular symphysis and retromolar region to reconstruct maxillary sinus height for posterior dental implant placement and the effect of these disturbances on patient satisfaction. MATERIALS AND METHODS: Fifty-four patients were invited to participate in this study. Autogenous bone graft was harvested from the mandibular symphysis and retromolar regions. After the procedure, the patients were evaluated by means of an adapted questionnaire to determine if they had complaints of neurosensory disturbances at the following time intervals: immediately, 1, 2-5, 6, 7-11, and 12 months postsurgery. RESULTS: Immediately after surgery, 28 patients described sensory changes and 25 reported paresthesia of inferior lip. Only three patients reported pain, and one patient experienced dental hypersensitivity after the surgical procedure. During the evaluation period, the patients reported a decrease in paresthesia and a return of sensation to areas innervated by the IAN. After 12 months, five patients still reported paresthesia of areas innervated by the IAN. Beside this, patients reported significant clinical improvement from the beginning of the evaluation, as 49 patients were satisfied with their treatment outcomes. CONCLUSION: Harvesting bone grafts from the mandibular symphysis results in greater postoperative morbidity upon immediate evaluation compared with bone graft harvesting from the retromolar region. Nevertheless, during clinical follow-up, the results of both treatments showed that sensation was eventually recovered, depending on the healing period.

Bioactive glass added to autogenous bone graft in maxillary sinus augmentation: a prospective histomorphometric, immunohistochemical, and bone graft resorption assessment.

OBJECTIVE: The aim of this study was to compare the bone resorption rate, histomorphometry and immunohistochemical findings of bioactive glass (Biogran; Biomet, Warsaw, IN, USA) mixed with autogenous bone grafts (1:1) and autogenous bone graft isolate in maxillary sinus elevation surgery. MATERIAL AND METHODS: A total of 9 maxillary sinuses were grafted with Biogran with autogenous bone graft (group 1) and 12 were mixed with autogenous bone graft (group 2). Postoperative cone beam computed tomography (CBCT) was used to measure the initial graft volume after 15 days (T1), and 6 months later, another CBCT scan was performed to evaluate the final graft volume (T2) and determine the graft resorption rate. The resorption outcomes were 37.9%±18.9% in group 1 and 45.7%±18.5% in group 2 (P=0.82). After 6 months, biopsies were obtained concurrent with the placement of dental implants; these implants were subjected to histomorphometric analysis and immunohistochemical analysis for tartrate-resistant acid phosphatase (TRAP). RESULTS: The average bone formation in group 1 was 36.6%±12.9 in the pristine bone region, 33.2%±13.3 in the intermediate region, and 45.8%±13.8 in the apical region; in group 2, the values were 34.4%±14.4, 35.0%±13.9, and 42.0%±16.6 of new bone formation in the pristine bone, intermediate, and apical regions, respectively. Immunostaining for TRAP showed poor clastic activity in both groups, which can indicate that those were in the remodeling phase. CONCLUSIONS: The similarity between the groups in the formation and maintenance of the graft volume after 6 months suggests that the bioactive glass mixed with autogenous bone (1:1) can be used safely as a bone substitute for the maxillary sinus lift.

Does lag screw fixation of condylar fractures result in adequate stability? A finite element analysis.

The great incidence and controversies related to the diagnosis, treatment, surgical accesses, and type of osteosynthesis materials confer an outstanding role to condylar fractures among facial fractures. Plate configurations, with diverse formats and sizes, may be used to surgically resolve condylar fractures. With the purpose of improving the advantages and minimizing the disadvantages of fixation techniques, the neck screw was developed aiming at the needed stabilization to render a correct fixation through a system of dynamic compression. This is achieved by increasing the contact between the fractured bone stumps, as well as assisting at the time of fracture reduction. The present paper aims at comparing the fixation and stability of mandibular condylar fractures using the neck screw and an overlaid "L"-shaped-4-hole-2 mm plate on the one hand, with a system in which the neck screw and the "L"-shaped plate form a single structure, having been joined by a welded point, on the other hand. The results with the neck screw are satisfactory, and, thus, it is an alternative for the reduction and fixation of fractures of the mandibular condyle, whether or not a plate is joined to the structure, provided it is correctly prescribed and with adequate surgical sequence and technique.

Histomorphometric and immunohistochemical assessment of RUNX2 and VEGF of Biogran™ and autogenous bone graft in human maxillary sinus bone augmentation: A prospective and randomized study.

BACKGROUND: Few studies have been conducted to assess new bone formation using Biogran, a bioactive glass, in maxillary sinus bone augmentation through a prospective and randomized evaluation. Moreover, there are no studies that evaluate cellular behavior by immunohistochemical assessment for osteoblastic and vascular activity during bone repair. PURPOSE: The aim of this study is to compare new bone formation and cellular behavior with Biogran alone, a 1:1 combination of Biogran and autogenous bone graft, and autogenous bone graft alone in human maxillary sinuses. MATERIALS AND METHODS: Ten maxillary sinuses were grafted with Biogran (Group 1), 10 grafted with Biogran added to autogenous bone graft in a 1:1 ratio (Group 2), and 10 grafted with autogenous bone graft alone (Group 3). After 6 months of bone healing, samples were obtained concurrent to the dental implants' placement to be evaluated by histomorphometric and immunohistochemical assessment for RUNX2 and vascular endothelial growth factor (VEGF). RESULTS: The amount of new bone formation in Group 1 was 42.0 ± 7.3% in the pristine bone region, 40.7 ± 14.0% in the intermediate region, and 45.6 ± 13.5% in apical region. In Group 2, for pristine bone, intermediate, and apical regions, new bone formation was 36.6 ± 12.9%, 33.2 ± 13.3%, and 45.8 ± 13.9%, respectively. Group 3 showed new bone formation of 37.3 ± 11.6%, 35.3 ± 14.7%, and 39.9 ± 15.8% in pristine bone, intermediate, and apical regions, respectively. The immunolabeling for RUNX2 showed low cellular activity in osteoblasts for all groups, and the VEGF assessment demonstrated moderate cellular activity in Groups 1 and 2; however, Group 3 presented with low activity in the pristine bone region, followed by moderate activity in the intermediate and apical region. CONCLUSION: This study demonstrates that Biogran and its combination with autogenous bone graft 1:1 are good bone substitutes due to their similarity to autogenous bone graft.

The new bone formation in human maxillary sinuses using two bone substitutes with different resorption types associated or not with autogenous bone graft: a comparative histomorphometric, immunohistochemical and randomized clinical study

Abstract Objective The aim of this study is to evaluate the new bone and connective tissue formation and the biomaterial remaining after maxillary sinus bone augmentation using 5 different bone substitutes. The osteocalcin immunolabeling was performed to demonstrate their calcification and the possibility of receiving dental implants. Methodology 40 patients underwent maxillary sinus bone augmentation and were divided in 5 groups: Group 1 with 8 maxillary sinuses were grafted with autogenous bone graft (AB); Group 2 with 8 maxillary sinuses grafted with bioactive glass (BG); Group 3 with 8 maxillary sinuses grafted with bioactive glass added to autogenous bone graft (BG + AB) 1:1; Group 4 with 8 maxillary sinuses grafted with Bio-Oss (BO) and Group 5 with 8 maxillary sinuses grafted with Bio-Oss added to autogenous bone graft (BO + AB) 1:1. Results In group AB, 37.8% of bone was formed in the pristine bone region, 38.1% in the intermediate and 44.5% in the apical region. In group BG, 43.6% was formed in the pristine bone, 37% in the intermediate and 49.3% in the apical region. In group BG + AB 1:1, 39.0% was formed in the pristine bone region, 34.8% in the intermediate and 36.8% in apical region. In group BO, 33.4% was formed in the pristine bone, 32.5% in the intermediate and 34.3% in the apical region. In group BO + AB 1:1, 32.8% was formed in the pristine bone, 36.1% in intermediate and 27.8% in the apical regions. The immunolabeling for osteocalcin showed an intensive staining for all groups, which could demonstrate the calcification of the bone formed. Conclusion This study showed that the groups evaluated formed a suitable lamellar bone in the maxillary sinus reconstruction after six months of bone healing, thus being indicated to receive dental implants.

Avaliação retrospectiva de pacientes submetidos à lipoplastia facial: uma nova abordagem cirúrgica e análise subjetiva da satisfação do paciente / Retrospective evaluation of patients submitted to facial lipoplasty: a new surgical approach and subjective analysis of patient satisfaction

Introdução: Atualmente, a lipoplastia facial tem sido muito estudada, e isso se justifica em decorrência dos resultados estéticos, dentre eles a valorização da projeção do osso zigomático. Poucas técnicas cirúrgicas foram descritas, principalmente em relação ao resultado de satisfação e do acesso que é realizado para a remoção da bola de Bichat. Este estudo tem como objetivo realizar uma análise de banco de dados para avaliar a satisfação do procedimento de bichectomia pelos próprios pacientes, além de descrever uma abordagem cirúrgica distinta da encontrada na literatura. Metodologia: Foram selecionados 47 pacientes para o procedimento, sendo este realizado em nível ambulatorial, seguindo a mesma técnica cirúrgica em todos os pacientes, os quais foram acompanhados por 7, 14, 30 e 60 dias de pós-operatório, verificando-se o processo de cicatrização e dados referentes à satisfação em todas as consultas realizadas. Resultados: Mediante a técnica empregada, houve um bom número inicial de pacientes satisfeitos com a cirurgia, que aumentou gradativamente conforme o acompanhamento. Conclusões: Assim, confirma-se que a bichectomia é um procedimento seguro, com poucas complicações, devendo haver uma maior amplitude nas pesquisas que visem avaliar o grau de satisfação dos pacientes para atender melhor as suas expectativas... (AU)

Introduction: Facial lipoplasty has been widely studied today because of the aesthetic results provided, such as the enhancement of the ossozygomatic projection. Few surgical techniques have been described, mainly in regard to the satisfaction result and the access that is made for the removal of the bichat ball. The objective of the present study is to perform a database analysis to evaluate satisfaction of the bichectomy procedure by the patients themselves, in addition to describing a surgical approach distinct from that found in the literature. Methodology: 47 patients were selected for the procedure, and the procedure was performed on an outpatient basis, following the same surgical technique in all patients, which were followed for 7, 14, 30 and 60 postoperative days, and the healing process was verified and satisfaction data in all consultations. Results: As a result, it can be observed that by the technique employed, there was a good initial number of patients satisfied with the surgery, which increased gradually as the follow-up in the more returns. Conclusions: Thus, it is confirmed that bichectomy is a safe procedure, with few complications, and more research should be done to evaluate the degree of patient satisfaction to meet their expectations... (AU)

Estudo comparativo do tratamento de fraturas de ângulo mandibular: análise retrospectiva de sete anos / Comparative study of mandibular angle fractures treatment: a seven years retrospective analysys

Introdução: Fraturas mandibulares apresentam alta incidência após traumas do complexo maxilomandibular, sendo a região goníaca uma das mais afetadas. Devido à biomecânica complexa da região, altos índices de complicações pós-operatórias estão relacionados às fraturas do ângulo mandibular. Objetivos: Avaliar o tratamento das fraturas de ângulo mandibular e comparar as taxas de complicações de duas técnicas diferentes de osteossíntese. Métodos: Análise retrospectiva de prontuários dos pacientes diagnosticados com fraturas de ângulo mandibular, atendidos no período de junho de 2007 a junho de 2014. Os pacientes foram divididos em grupo I (uma miniplaca) e grupo II (duas miniplacas). Informações sobre a etiologia do trauma, características da fratura, tratamento e complicações foram colhidas e analisadas por meio de frequência absoluta e relativa. Resultados: Foram incluídos 50 pacientes com 53 fraturas de ângulo mandibular. O tempo médio decorrido entre o trauma e o procedimento cirúrgico foi de 9,59 dias, e 29 pacientes apresentavam dentes associados às fraturas. O índice geral de insucesso foi de 28,31%, e as complicações mais prevalentes foram os distúrbios infecciosos e mobilidade interfragmentária. Conclusões: Não houve diferença no índice de complicações entre os grupos analisados, e essas taxas concordam com o descrito na literatura... (AU)

Introduction: Mandibular fractures are highly incidence in the maxillomandibular trauma, and the goniac region is one of the most affected. Due to complex biomechanics, high rates of postoperative complications are related to fractures of the mandibular angle. Objectives: To evaluate the treatment of mandibular angle fractures and compare the complication rates of two different techniques of osteosynthesis. Methods: Retrospective analysis of medical records of patients diagnosed with mandibular angle fractures from June 2007 to June 2014. The patients were divided into group I (one plate) and group II (two plates). Information on the etiology of trauma, fracture settings, treatment and complications were analyzed using absolute and relative frequency. Results: 50 patients with 53 mandibular angle fractures were included. The average time elapsed between trauma and surgery was 9.59 days and 29 patients had teeth associated with fractures.. The general failure rate was 28.31%, and the most prevalent complications were infectious disorders and interfragmentary mobility. Conclusions: There was no difference in the complication rate between the groups analyzed and these rates agree with that described in the literature... (AU)

Bioactive glass added to autogenous bone graft in maxillary sinus augmentation: a prospective histomorphometric, immunohistochemical, and bone graft resorption assessment

Abstract Objective The aim of this study was to compare the bone resorption rate, histomorphometry and immunohistochemical findings of bioactive glass (Biogran; Biomet, Warsaw, IN, USA) mixed with autogenous bone grafts (1:1) and autogenous bone graft isolate in maxillary sinus elevation surgery. Material and Methods A total of 9 maxillary sinuses were grafted with Biogran with autogenous bone graft (group 1) and 12 were mixed with autogenous bone graft (group 2). Postoperative cone beam computed tomography (CBCT) was used to measure the initial graft volume after 15 days (T1), and 6 months later, another CBCT scan was performed to evaluate the final graft volume (T2) and determine the graft resorption rate. The resorption outcomes were 37.9%±18.9% in group 1 and 45.7%±18.5% in group 2 (P=0.82). After 6 months, biopsies were obtained concurrent with the placement of dental implants; these implants were subjected to histomorphometric analysis and immunohistochemical analysis for tartrate-resistant acid phosphatase (TRAP). Results The average bone formation in group 1 was 36.6%±12.9 in the pristine bone region, 33.2%±13.3 in the intermediate region, and 45.8%±13.8 in the apical region; in group 2, the values were 34.4%±14.4, 35.0%±13.9, and 42.0%±16.6 of new bone formation in the pristine bone, intermediate, and apical regions, respectively. Immunostaining for TRAP showed poor clastic activity in both groups, which can indicate that those were in the remodeling phase. Conclusions The similarity between the groups in the formation and maintenance of the graft volume after 6 months suggests that the bioactive glass mixed with autogenous bone (1:1) can be used safely as a bone substitute for the maxillary sinus lift.

Cirurgia Odontológica em Paciente Portador de Hipofibrinogenemia / Dental Surgery In Patient With Hypofibrinogenemia

O fibrinogênio é uma proteína do sangue, fundamental na fase final de coagulação sanguínea. A hipofibrinogenemia é uma doença hemorrágica rara, em que ocorre uma deficiência quantitativa na produção do fibrinogênio. Os sintomas variam de acordo com a quantidade de fibrinogênio produzido pelo organismo e sua capacidade de funcionamento. Pacientes diagnosticados com essa condição que necessitem de cirurgia odontológica demandam de planejamento multidisciplinar. O presente estudo teve por objetivo relatar a conduta pré, trans e pós-operatória de um paciente portador de hipofibrinogenemia, com necessidade de cirurgia odontológica para exodontia de terceiros molares. O procedimento foi planejado pelo cirurgião-dentista em conjunto com o hematologista, em que os devidos cuidados foram adotados para segurança e conforto do paciente. A cirurgia foi realizada sem intercorrências e com sangramento compatível a não portadores dessa alteração... (AU)

Fibrinogen is an essential blood protein involved in the final stage of blood coagulation. The hypofibrinogenemia is a rare bleeding disorder that promotes a quantitative deficiency in the fibrinogen production. Symptoms vary according to the quantity of fibrinogen synthesis and its function in the organism. Patients diagnosed with this condition will demand multidisciplinary treatment planning in erder to have oral surgery procedures. The aim of this study was to report pre, trans, and postoperative management of a patient with hypofibrinogenemia requering oral surgery for third molars extraction. The procedure was planned by the dental surgeon in conjunction with the hematologist, where due care was taken for patient safety and comfort. The surgery was performed without complications, and bleeding was compatible with those who did not... (AU)

Mandibular osteonecrosis induced by bisphosphonates in a carrier of chronicle kidney disease / Osteonecrosis mandibular inducida por bifosfonatosen un portador de enfermedad renal crónica

he bisphosphonates are synthetic substances of inorganic pyrophosphate that havebeen the basis of treatment of patients with osteolytic diseases, such as multiple myeloma, malignanthypercalcemia, Paget's disease, or patients with bone metastases. Its main pharmacological effect is inhibitionof bone resorption caused by osteoclasts, which have a reduced function. Their adverse effects are infrequentbut include pyrexia, impaired renal function, hypocalcemia, and more recently, maxillo-mandibular ostenecroseinduced bofosfonatos. In this report we describe a clinical case of jaw osteonecrosis induced by bisphosphonatesin patient with chronic kidney disease and the treatment protocol performed

Los bisfosfonatos son sustancias sintéticas de pirofosfato inorgánico que han sido la base del tratamiento de pacientes con enfermedades osteolíticas, como mieloma múltiple, hipercalcemia maligna, enfermedad de Paget o pacientes con metástasis ósea. Su principal efecto farmacológico es la inhibición dela resorción ósea causada por osteoclastos, que tienen una función reducida. Sus efectos adversos son infrecuentes, pero incluyen pirexia, deterioro de la función renal, hipocalcemia y, más recientemente, indujo inducido por bicosfonatos maxilomandibular. En este informe se describe un caso clínico de osteonecrosis mandibular inducida por bifosfonatos en pacientes con enfermedad renal crónica y el protocolo de trata-miento realizado.

Paraendodontic surgery: case report / Cirurgia paraendodôntica: relato de caso

ABSTRACT Paraendodontic surgeries have been increasingly used to solve problems related to failures in conventional endodontic treatment. Better anatomical knowledge of the structures as well as the development of techniques and materials involved has resulted in substantial paraendodontic surgery increase and success. In some cases, teeth endodontic treatment highly benefits treatment accomplishment. This report describes a case of an endodontic treatment complemented by paraendodontic surgery in periapical region of 21, 22 and 23 of a female patient who had been treated at the clinic of the Brazilian Dental Association Dentistry - in the city of Cascavel, State of Parana, Brazil. The case presents a 12-month follow-up for the resolution of painful symptoms, lesion reduction, and bone formation. Literature review was performed regarding paraendodontic surgery in order to assess the determining factors, failure causes and procedure indications/contraindications, as well.

RESUMO A cirurgia paraendodôntica tem sido cada vez mais utilizada para sanar problemas inerentes aos insucessos no tratamento endodôntico convencional. O melhor conhecimento anatômico das estruturas envolvidas bem como a evolução das técnicas e dos materiais proporcionou um aumento significativo da utilização desta técnica e, por conseguinte seu maior sucesso. O tratamento endodôntico primário de um elemento dentário pode atingir altos índices de sucesso. Tornando-se, portanto, imprescindível para se atingir o sucesso do tratamento de alguns casos. Neste trabalho descreve-se um caso de tratamento endodôntico complementado por cirurgia paraendodôntica em região periapical dos elementos dentais 21, 22 e 23 de paciente do gênero feminino que foi tratada na Clínica de Odontologia da Associação Brasileira de Odontologia - Regional de Cascavel, Pr. O caso apresenta acompanhamento de 12 meses com resolução da sintomatologia dolorosa, redução da lesão e neoformação óssea. Foi realizada uma discussão com revisão da literatura sobre a cirurgia paraendodôntica avaliando os fatores determinantes, causas de insucessos, indicações e contraindicações do procedimento.

Acadêmicos e profissionais da odontologia estão preparados para salvar vidas? / Are dentistry students and professionals prepared to save lives?

Introdução: O cirurgião-dentista enfrenta, no cotidiano de seu trabalho, o risco de se deparar com eventos emergenciais que envolvam a saúde geral. A emergência é definida como uma situação em que não pode haver uma protelação no atendimento, o qual deve ser imediato. Objetivos: Verificar se os profissionais e estudantes de odontologia estão preparados para numa eventualidade, diante de uma parada cardiorrespiratória, realizar com eficiência as manobras de ressuscitação cardiorrespiratória, evitando consequências indesejadas, que podem levar à morte do paciente. Métodos: Os dados foram obtidos mediante questionário elaborado para avaliar o nível de conhecimento sobre a sequência correta das manobras de ressuscitação cardiorrespiratória, aplicado aos alunos de graduação do segundo ao quinto ano e de pós-graduação da universidade. Foram distribuídos 142 questionários, juntamente com um termo de consentimento livre e esclarecido. Resultados: Constatou-se que apenas 15% dos entrevistados emitiram respostas consideradas corretas e houve 85% de respostas erradas. Conclusões: O cirurgião-dentista deve estar preparado para uma situação de emergência, evitando consequências indesejadas, tal como a morte do paciente. O índice de acertos foi muito baixo. As técnicas de ressuscitação cardiorrespiratória devem ser revisadas continuadamente, num período inferior a um ano, pois a maior parte dos alunos de todos os grupos pesquisados não assimilou de forma correta a técnica ou a esqueceu em razão da falta de treinamento prático ou da baixa incidência dessa emergência.