Detalles de la búsqueda
1.
Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [14C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [14C]Thiocyanate.
Drug Metab Dispos
; 52(5): 323-336, 2024 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38360917
2.
Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke.
Regul Toxicol Pharmacol
; 145: 105498, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37778433
3.
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
Bioorg Med Chem Lett
; 60: 128549, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35041943
4.
Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes.
Xenobiotica
; 52(2): 105-112, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34904522
5.
The impact of radiochemistry in drug projects: The use of C-14 label in the AZD8529, AZD7325, and AZD6280 projects.
J Labelled Comp Radiopharm
; 64(2): 65-72, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33326121
6.
Late-occurring and Long-circulating Metabolites of GABAAα2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance.
Drug Metab Dispos
; 46(3): 303-315, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29311137
7.
Synthesis of C-14 labeled GABAA α2/α3 selective partial agonists and the investigation of late-occurring and long-circulating metabolites of GABAA receptor modulator AZD7325.
J Labelled Comp Radiopharm
; 61(5): 415-426, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29314165
8.
Identification of Protonated Sulfone and Aromatic Carboxylic Acid Functionalities in Organic Molecules by Using Ion-Molecule Reactions Followed by Collisionally Activated Dissociation in a Linear Quadrupole Ion Trap Mass Spectrometer.
Anal Chem
; 89(14): 7398-7405, 2017 07 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28621918
9.
CYP-Mediated Sulfoximine Deimination of AZD6738.
Drug Metab Dispos
; 45(11): 1133-1138, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28835442
10.
Mouse Red Blood Cell-Mediated Rare Xenobiotic Phosphorylation of a Drug Molecule Not Intended to Be a Kinase Substrate.
Drug Metab Dispos
; 45(12): 1345-1353, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28986473
11.
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
Bioorg Med Chem Lett
; 72: 128856, 2022 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35728998
12.
Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.
Bioorg Med Chem Lett
; 26(19): 4775-4780, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27578247
13.
Lipid Peroxide-Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples.
Drug Metab Dispos
; 43(10): 1441-9, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26203069
14.
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 67(10): 8122-8140, 2024 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38712838
15.
The Importance of Tracking "Missing" Metabolites: How and Why?
J Med Chem
; 66(23): 15586-15612, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37769129
16.
Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct.
Drug Metab Dispos
; 40(6): 1151-63, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22397852
17.
BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS.
Drug Metab Pharmacokinet
; 42: 100433, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34896750
18.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-34734694
19.
In vitro and in vivo metabolism of a selective δ-opioid receptor.
Drug Metab Dispos
; 39(10): 1883-94, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21752944
20.
Absorption, excretion, and metabolism of a potential GABA-A α2/3 receptor modulator in rats.
Xenobiotica
; 41(5): 385-99, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21210737