Miniaturized Wirelessly Powered and Controlled Implants for Multisite Stimulation.

This paper presents a miniaturized implant with a diameter of only 14 mm, which houses a novel System on Chip (SoC) enabling two voltage level stimulation of up to 16 implants using a single Tx coil. Each implant can operate at a distance of 80 mm in the air through the inductive resonant link. The SoC consumes only 27 µW static power and enables two channels with stimulation amplitudes of 1.8 V and 3.3 V and timing resolution of 100 µs. The SoC is implemented in the standard 180 nm complementary metal oxide semiconductor (CMOS) technology and has an area of 0.75 mm × 1.6 mm. The SoC comprises an RF rectifier, low drop-out regulator (LDO), error detection block, clock data recovery, finite state machine (FSM), and output stage. Each implant has a PCB-defined passcode, which enables the individual addressability of the implants for synchronized therapies. The implantable device weighs only 80 mg and sizes 20.1 mm3. Tolerance of up to 70° to angular misalignment was measured at a distance of 50 mm. The efficacy of bilateral stimulation was further verified by implanting two devices on two sides of a pig's neck and performing bilateral vagus nerve stimulation (VNS), while monitoring the heart rate.

A Fully Wireless and Batteryless Localization System With 50 Micrometre Motion Detection Capability and Adaptive Transmitter Power Control for Point-of-Care Biomedical Applications.

Localization has varied applications in biomedicine, such as wireless capsule endoscopy (WCE), detection of cancerous tissue, drug delivery, robotic surgeries, and brain mapping. Currently, most localization systems are battery-powered and suffer from issues regarding battery leakage and limited battery life, resulting in potential health hazards and inconveniences when using them for continuous health monitoring applications. This article proposes an entirely wireless and battery-less 2D localization system consisting of an integrated circuit (IC) that is wirelessly powered at a distance of 4 cm by a 40.68 MHz radio frequency (RF) power of only 2 W. The proposed localization system wirelessly transmits a locked sub-harmonic 13.56 MHz signal generated from the wirelessly received 40.68 MHz RF power signal, eliminating the need for a power-hungry oscillator. Additionally, the system, having a measurement latency of 11.3 ms, has also been verified to sense motion as small as 50 [Formula: see text] as well as measure the rate of motion up to 10 beats per minute, therefore extending its application to the detection of physiological motions such as diaphragm motion during breathing. The localizer has a small form factor of 17 mm × 12 mm × 0.2 mm and consumes an average power of 6 µW. Ex vivo measurements using the localizer inside the porcine intestine demonstrate a localization accuracy of less than 5 mm.

Design and Implementation of Multisite Stimulation System Using a Double-Tuned Transmitter Coil and Miniaturized Implants.

This letter presents a double-tuned dual input transmitter coil operating at 13.56 MHz and 40.68 MHz industrial, scientific, and medical (ISM) bands for multisite biomedical applications. The proposed system removes the need for two separate coils, which reduces system size and unwanted couplings. The design and analysis of the double-tuned transmitter coil using a lumped element frequency trap are discussed in this letter. The transmitter achieves measured matching of -26.2 dB and -21.5 dB and isolation of -17.7 dB and -11.7dB at 13.56 MHz and 40.68 MHz, respectively. A 3 mm × 15 mm flexible coil is used as an implantable receiver. This letter shows synchronized multisite stimulation of two flexible implants at a distance of 2 cm while covered with 1 cm chicken breast.

Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs.

Neuromodulation of peripheral nerves has been clinically used for a wide range of indications. Wireless and batteryless stimulators offer important capabilities such as no need for reoperation, and extended life compared to their wired counterparts. However, there are challenging trade-offs between the device size and its operating range, which can limit their use. This study aimed to examine the functionality of newly designed wirelessly powered and controlled implants in vagus nerve stimulation for pigs. The implant used near field inductive coupling at 13.56 MHz industrial, scientific, and medical band to harvest power from an external coil. The circular implant had a diameter of 13 mm and weighed 483 mg with cuff electrodes. The efficiency of the inductive link and robustness to distance and misalignment were optimized. As a result, the specific absorption rate was orders of magnitude lower than the safety limit, and the stimulation can be performed using only 0.1 W of external power. For the first time, wireless and batteryless VNS with more than 5 cm operation range was demonstrated in pigs. A total of 84 vagus nerve stimulations (10 s each) have been performed in three adult pigs. In a quantitative comparison of the effectiveness of VNS devices, the efficiency of systems on reducing heart rate was similar in both conventional (75%) and wireless (78.5%) systems. The pulse width and frequency of the stimulation were swept on both systems, and the response for physiological markers was drawn. The results were easily reproducible, and methods used in this study can serve as a basis for future wirelessly powered implants.