1.
Angew Chem Int Ed Engl
; 51(44): 11126-30, 2012 Oct 29.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23037915
RESUMEN
A series of inhibitors of acetylcholinesterase (AChE) have been screened by back-scattering interferometry (BSI). Enzyme levels as low as 100â pM (22,000â molecules of AChE) can be detected. This method can be used to screen for mixed AChE inhibitors, agents that have shown high efficacy against Alzheimer's disease, by detecting dual-binding interactions. E = enzyme, I = inhibitor, S = substrate.