RESUMEN
Asthmatic patients receiving antileukotrienes may develop hypereosinophilia as a part of a Churg-Strauss syndrome. It is unclear if this effect is directly related to the administration of antileukotrienes or a consequence of the corticosteroid-sparing effect of antileukotrienes unmasking a Churg-Strauss syndrome. We present a case of hypereosinophilia related to zafirlukast therapy. The patient did not fulfil criteria for Churg-Strauss syndrome. Symptoms and laboratory findings improved after zafirlukast was removed.
Asunto(s)
Asma/tratamiento farmacológico , Síndrome de Churg-Strauss/inducido químicamente , Antagonistas de Leucotrieno/efectos adversos , Compuestos de Tosilo/efectos adversos , Antiinflamatorios no Esteroideos/inmunología , Síndrome de Churg-Strauss/diagnóstico , Humanos , Indoles , Masculino , Persona de Mediana Edad , Fenilcarbamatos , SulfonamidasRESUMEN
We report a patient who developed asthma associated with exposure to cats. During his evolution he presented pulmonary infiltrates accompanied by eosinophilia in blood and sputum, hemoptysis and flu-like symptoms. The sera contained specific IgE and precipitating antibodies to cat epithelium. After a year without contact with cats, precipitating antibodies were negative, and a bronchial provocation test only demonstrated an immediate response.