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1.

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling.

Xian, Hongxu; Watari, Kosuke; Sanchez-Lopez, Elsa; Offenberger, Joseph; Onyuru, Janset; Sampath, Harini; Ying, Wei; Hoffman, Hal M; Shadel, Gerald S; Karin, Michael.

Immunity ; 55(8): 1370-1385.e8, 2022 08 09.

Artículo en Inglés | MEDLINE | ID: mdl-35835107

2.

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong, Zhenyu; Umemura, Atsushi; Sanchez-Lopez, Elsa; Liang, Shuang; Shalapour, Shabnam; Wong, Jerry; He, Feng; Boassa, Daniela; Perkins, Guy; Ali, Syed Raza; McGeough, Matthew D; Ellisman, Mark H; Seki, Ekihiro; Gustafsson, Asa B; Hoffman, Hal M; Diaz-Meco, Maria T; Moscat, Jorge; Karin, Michael.

Cell ; 164(5): 896-910, 2016 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-26919428

3.

A guiding map for inflammation.

Netea, Mihai G; Balkwill, Frances; Chonchol, Michel; Cominelli, Fabio; Donath, Marc Y; Giamarellos-Bourboulis, Evangelos J; Golenbock, Douglas; Gresnigt, Mark S; Heneka, Michael T; Hoffman, Hal M; Hotchkiss, Richard; Joosten, Leo A B; Kastner, Daniel L; Korte, Martin; Latz, Eicke; Libby, Peter; Mandrup-Poulsen, Thomas; Mantovani, Alberto; Mills, Kingston H G; Nowak, Kristen L; O'Neill, Luke A; Pickkers, Peter; van der Poll, Tom; Ridker, Paul M; Schalkwijk, Joost; Schwartz, David A; Siegmund, Britta; Steer, Clifford J; Tilg, Herbert; van der Meer, Jos W M; van de Veerdonk, Frank L; Dinarello, Charles A.

Nat Immunol ; 18(8): 826-831, 2017 Jul 19.

Artículo en Inglés | MEDLINE | ID: mdl-28722720

4.

Author Correction: A guiding map for inflammation.

Netea, Mihai G; Balkwill, Frances; Chonchol, Michel; Cominelli, Fabio; Donath, Marc Y; Giamarellos-Bourboulis, Evangelos J; Golenbock, Douglas; Gresnigt, Mark S; Heneka, Michael T; Hoffman, Hal M; Hotchkiss, Richard; Joosten, Leo A B; Kastner, Daniel L; Korte, Martin; Latz, Eicke; Libby, Peter; Mandrup-Poulsen, Thomas; Mantovani, Alberto; Mills, Kingston H G; Nowak, Kristen L; O'Neill, Luke A; Pickkers, Peter; van der Poll, Tom; Ridker, Paul M; Schalkwijk, Joost; Schwartz, David A; Siegmund, Britta; Steer, Clifford J; Tilg, Herbert; van der Meer, Jos W M; van de Veerdonk, Frank L; Dinarello, Charles A.

Nat Immunol ; 22(2): 254, 2021 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-33288963

5.

The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity.

Putnam, Christopher D; Broderick, Lori; Hoffman, Hal M.

Immunol Rev ; 322(1): 259-282, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38146057

6.

Antisense Oligonucleotide Therapy Decreases IL-1ß Expression and Prolongs Survival in Mutant Nlrp3 Mice.

Kaufmann, Benedikt; de Los Reyes Jiménez, Marta; Booshehri, Laela M; Onyuru, Janset; Leszczynska, Aleksandra; Uri, Anna; Michel, Sven; Klar, Richard; Jaschinski, Frank; Feldstein, Ariel E; Broderick, Lori; Hoffman, Hal M.

J Immunol ; 211(2): 287-294, 2023 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-37256266

7.

Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis.

Knorr, Jana; Kaufmann, Benedikt; Inzaugarat, Maria Eugenia; Holtmann, Theresa Maria; Geisler, Lukas; Hundertmark, Jana; Kohlhepp, Marlene Sophia; Boosheri, Laela M; Chilin-Fuentes, Daisy R; Birmingham, Amanda; Fisch, Kathleen M; Schilling, Joel D; Loosen, Sven H; Trautwein, Christian; Roderburg, Christoph; Demir, Münevver; Tacke, Frank; Hoffman, Hal M; Feldstein, Ariel E; Wree, Alexander.

Hepatology ; 77(6): 1968-1982, 2023 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-36059147

8.

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida, Lucia; Khare, Sonal; Misharin, Alexander V; Patel, Rajul; Ratsimandresy, Rojo A; Wallin, Melissa C; Perlman, Harris; Greaves, David R; Hoffman, Hal M; Dorfleutner, Andrea; Stehlik, Christian.

Immunity ; 43(2): 264-76, 2015 Aug 18.

Artículo en Inglés | MEDLINE | ID: mdl-26275995

9.

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis.

Kaufmann, Benedikt; Leszczynska, Aleksandra; Reca, Agustina; Booshehri, Laela M; Onyuru, Janset; Tan, ZheHao; Wree, Alexander; Friess, Helmut; Hartmann, Daniel; Papouchado, Bettina; Broderick, Lori; Hoffman, Hal M; Croker, Ben A; Zhu, Yanfang Peipei; Feldstein, Ariel E.

EMBO Rep ; 23(11): e54446, 2022 11 07.

Artículo en Inglés | MEDLINE | ID: mdl-36194627

10.

Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.

Povero, Davide; Lazic, Milos; McBride, Christopher; Ambrus-Aikelin, Geza; Stansfield, Ryan; Johnson, Casey D; Santini, Angelina M; Pranadinata, Rama F; McGeough, Matthew D; Stafford, Jeffrey A; Hoffman, Hal M; Feldstein, Ariel E; Veal, James M; Bain, Gretchen.

J Pharmacol Exp Ther ; 386(2): 242-258, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37308266

11.

NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH.

Calcagno, David M; Chu, Angela; Gaul, Susanne; Taghdiri, Nika; Toomu, Avinash; Leszczynska, Aleksandra; Kaufmann, Benedikt; Papouchado, Bettina; Wree, Alexander; Geisler, Lukas; Hoffman, Hal M; Feldstein, Ariel E; King, Kevin R.

Hepatology ; 76(3): 727-741, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-34997987

12.

Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children.

Kim, Jihoon; Shimizu, Chisato; He, Ming; Wang, Hao; Hoffman, Hal M; Tremoulet, Adriana H; Shyy, John Y-J; Burns, Jane C.

Int J Mol Sci ; 24(15)2023 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-37569694

13.

The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist.

Romano, Micol; Arici, Z Serap; Piskin, David; Alehashemi, Sara; Aletaha, Daniel; Barron, Karyl S; Benseler, Susanne; Berard, Roberta; Broderick, Lori; Dedeoglu, Fatma; Diebold, Michelle; Durrant, Karen L; Ferguson, Polly; Foell, Dirk; Hausmann, Jonathan; Jones, Olcay Y; Kastner, Daniel L; Lachmann, Helen J; Laxer, Ronald M; Rivera, Dorelia; Ruperto, Nicolino; Simon, Anna; Twilt, Marinka; Frenkel, Joost; Hoffman, Hal; de Jesus, Adriana A; Kuemmerle-Deschner, Jasmin Beate; Ozen, Seza; Gattorno, Marco; Goldbach-Mansky, Raphaela; Demirkaya, Erkan.

Ann Rheum Dis ; 81(7): 907-921, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35623638

14.

Inflammasome Activation in Children With Kawasaki Disease and Multisystem Inflammatory Syndrome.

Wang, Wei-Ting; He, Ming; Shimizu, Chisato; Croker, Ben A; Hoffman, Hal M; Tremoulet, Adriana H; Burns, Jane C; Shyy, John Y-J.

Arterioscler Thromb Vasc Biol ; 41(9): 2509-2511, 2021 09.

Artículo en Inglés | MEDLINE | ID: mdl-34261329

15.

Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy.

Wilde, Shyra; Olivares, Katherine L; Nizet, Victor; Hoffman, Hal M; Radhakrishna, Suhas; LaRock, Christopher N.

J Infect Dis ; 223(7): 1260-1264, 2021 04 08.

Artículo en Inglés | MEDLINE | ID: mdl-32808035

16.

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.

Gaul, Susanne; Leszczynska, Aleksandra; Alegre, Fernando; Kaufmann, Benedikt; Johnson, Casey D; Adams, Leon A; Wree, Alexander; Damm, Georg; Seehofer, Daniel; Calvente, Carolina J; Povero, Davide; Kisseleva, Tatiana; Eguchi, Akiko; McGeough, Matthew D; Hoffman, Hal M; Pelegrin, Pablo; Laufs, Ulrich; Feldstein, Ariel E.

J Hepatol ; 74(1): 156-167, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-32763266

17.

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.

De Benedetti, Fabrizio; Gattorno, Marco; Anton, Jordi; Ben-Chetrit, Eldad; Frenkel, Joost; Hoffman, Hal M; Koné-Paut, Isabelle; Lachmann, Helen J; Ozen, Seza; Simon, Anna; Zeft, Andrew; Calvo Penades, Inmaculada; Moutschen, Michel; Quartier, Pierre; Kasapcopur, Ozgur; Shcherbina, Anna; Hofer, Michael; Hashkes, Philip J; Van der Hilst, Jeroen; Hara, Ryoki; Bujan-Rivas, Segundo; Constantin, Tamas; Gul, Ahmet; Livneh, Avi; Brogan, Paul; Cattalini, Marco; Obici, Laura; Lheritier, Karine; Speziale, Antonio; Junge, Guido.

N Engl J Med ; 378(20): 1908-1919, 2018 05 17.

Artículo en Inglés | MEDLINE | ID: mdl-29768139

18.

cASCading specks.

Broderick, Lori; Hoffman, Hal M.

Nat Immunol ; 15(8): 698-700, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-25045869

19.

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis.

Kaufmann, Benedikt; Leszczynska, Aleksandra; Reca, Agustina; Booshehri, Laela M; Onyuru, Janset; Tan, ZheHao; Wree, Alexander; Friess, Helmut; Hartmann, Daniel; Papouchado, Bettina; Broderick, Lori; Hoffman, Hal M; Croker, Ben A; Zhu, Yanfang Peipei; Feldstein, Ariel E.

EMBO Rep ; 25(1): 455, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-38216786

20.

Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist.

Broderick, Lori; Hoffman, Hal M.

J Allergy Clin Immunol ; 146(5): 960-966.e2, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-33002514

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Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling.

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

A guiding map for inflammation.

Author Correction: A guiding map for inflammation.

The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity.

Antisense Oligonucleotide Therapy Decreases IL-1ß Expression and Prolongs Survival in Mutant Nlrp3 Mice.

Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis.

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis.

Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.

NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH.

Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children.

Inflammasome Activation in Children With Kawasaki Disease and Multisystem Inflammatory Syndrome.

Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy.

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.

cASCading specks.

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis.

Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist.