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1.

A dual chain chimeric antigen receptor (CAR) in the native antibody format for targeting immune cells towards cancer cells without the need of an scFv.

Faitschuk, E; Nagy, V; Hombach, A A; Abken, H.

Gene Ther ; 23(10): 718-726, 2016 10.

Artículo en Inglés | MEDLINE | ID: mdl-27356950

2.

No stress--Hsp90 and signal transduction in Leishmania.

Hombach, A; Clos, J.

Parasitology ; 141(9): 1156-66, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24703183

3.

T cells redirected by a CD3Î¶ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term.

Chmielewski, M; Rappl, G; Hombach, A A; Abken, H.

Gene Ther ; 20(2): 177-86, 2013 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-22378346

4.

CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack.

Chmielewski, M; Hombach, A A; Abken, H.

Gene Ther ; 18(1): 62-72, 2011 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-20944680

5.

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response.

Hombach, A; Hombach, A A; Abken, H.

Gene Ther ; 17(10): 1206-13, 2010 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-20555360

6.

[Adoptive T-cell therapy of rhabdomyosarcoma]. / Adoptive T-Zell-Therapie des Rhabdomyosarkoms.

Simon-Keller, K; Paschen, A; Eichmüller, S; Gattenlöhner, S; Barth, S; Koscielniak, E; Leuschner, I; Stöbel, P; Hombach, A; Abken, H; Marx, A.

Pathologe ; 31 Suppl 2: 215-20, 2010 Oct.

Artículo en Alemán | MEDLINE | ID: mdl-20730458

7.

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity.

Hombach, A A; Kofler, D; Rappl, G; Abken, H.

Gene Ther ; 16(9): 1088-96, 2009 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-19554034

8.

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer.

Birkholz, K; Hombach, A; Krug, C; Reuter, S; Kershaw, M; Kämpgen, E; Schuler, G; Abken, H; Schaft, N; Dörrie, J.

Gene Ther ; 16(5): 596-604, 2009 May.

Artículo en Inglés | MEDLINE | ID: mdl-19158846

9.

An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30.

Hombach, A; Heuser, C; Sircar, R; Tillmann, T; Diehl, V; Pohl, C; Abken, H.

Cancer Res ; 58(6): 1116-9, 1998 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-9515791

10.

T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis.

Hombach, A; Sent, D; Schneider, C; Heuser, C; Koch, D; Pohl, C; Seliger, B; Abken, H.

Cancer Res ; 61(5): 1976-82, 2001 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-11280755

11.

Specific lysis of melanoma cells by receptor grafted T cells is enhanced by anti-idiotypic monoclonal antibodies directed to the scFv domain of the receptor.

Reinhold, U; Liu, L; Lüdtke-Handjery, H C; Heuser, C; Hombach, A; Wang, X; Tilgen, W; Ferrone, S; Abken, H.

J Invest Dermatol ; 112(5): 744-50, 1999 May.

Artículo en Inglés | MEDLINE | ID: mdl-10233766

12.

Isolation of single chain antibody fragments with specificity for cell surface antigens by phage display utilizing internal image anti-idiotypic antibodies.

Hombach, A; Pohl, C; Heuser, C; Sircar, R; Diehl, V; Abken, H.

J Immunol Methods ; 218(1-2): 53-61, 1998 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-9819122

13.

A novel strategy in the elimination of disseminated melanoma cells: chimeric receptors endow T cells with tumor specificity.

Abken, H; Hombach, A; Heuser, C; Reinhold, U.

Recent Results Cancer Res ; 158: 249-64, 2001.

Artículo en Inglés | MEDLINE | ID: mdl-11092052

14.

Chimeric anti-TAG72 receptors with immunoglobulin constant Fc domains and gamma or zeta signalling chains.

Hombach, A; Sircar, R; Heuser, C; Tillmann, T; Diehl, V; Kruis, W; Pohl, C; Abken, H.

Int J Mol Med ; 2(1): 99-103, 1998 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-9854151

15.

Activation of resting T cells against the CA 72-4 tumor antigen with an anti-CD3/CA 72-4 bispecific antibody in combination with a costimulatory anti-CD28 antibody.

Hombach, A; Mathas, S; Jensen, M; Tillmann, T; Menges, M; Diehl, V; Kruis, W; Pohl, C.

Anticancer Res ; 17(3C): 2025-32, 1997.

Artículo en Inglés | MEDLINE | ID: mdl-9216660

16.

Chronic inflammatory bowel disease and cancer.

Pohl, C; Hombach, A; Kruis, W.

Hepatogastroenterology ; 47(31): 57-70, 2000.

Artículo en Inglés | MEDLINE | ID: mdl-10690586

17.

Grafting T cells with tumor specificity: the chimeric receptor strategy for use in immunotherapy of malignant diseases.

Hombach, A; Pohl, C; Reinhold, U; Abken, H.

Hybridoma ; 18(1): 57-61, 1999 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-10211789

18.

The weal and woe of costimulation in the adoptive therapy of cancer with chimeric antigen receptor (CAR)-redirected T cells.

Hombach, A A; Holzinger, A; Abken, H.

Curr Mol Med ; 13(7): 1079-88, 2013 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-23116267

19.

Chimeric T-cell receptors: highly specific tools to target cytotoxic T-lymphocytes to tumour cells.

Abken, H; Hombach, A; Heuser, C; Sircar, R; Pohl, C; Reinhold, U.

Cancer Treat Rev ; 23(2): 97-112, 1997 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-9225961

20.

[Foreign body ingestion in childhood after dental care with rare sequela of perforation of the small intestine and pancreatic injury]. / Fremdkörperingestion im Kindesalter nach Zahnarztbesuch mit der seltenen Folge einer Dünndarmperforation und Pankreasverletzung.

Hombach, A; Waltermann, E; Kellner, M W.

Rofo ; 175(5): 708-9, 2003 May.

Artículo en Alemán | MEDLINE | ID: mdl-12743868

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