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1.

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

Schwitalla, Sarah; Fingerle, Alexander A; Cammareri, Patrizia; Nebelsiek, Tim; Göktuna, Serkan I; Ziegler, Paul K; Canli, Ozge; Heijmans, Jarom; Huels, David J; Moreaux, Guenievre; Rupec, Rudolf A; Gerhard, Markus; Schmid, Roland; Barker, Nick; Clevers, Hans; Lang, Roland; Neumann, Jens; Kirchner, Thomas; Taketo, Makoto M; van den Brink, Gijs R; Sansom, Owen J; Arkan, Melek C; Greten, Florian R.

Cell ; 152(1-2): 25-38, 2013 Jan 17.

Artículo en Inglés | MEDLINE | ID: mdl-23273993

2.

Retrograde movements determine effective stem cell numbers in the intestine.

Azkanaz, Maria; Corominas-Murtra, Bernat; Ellenbroek, Saskia I J; Bruens, Lotte; Webb, Anna T; Laskaris, Dimitrios; Oost, Koen C; Lafirenze, Simona J A; Annusver, Karl; Messal, Hendrik A; Iqbal, Sharif; Flanagan, Dustin J; Huels, David J; Rojas-Rodríguez, Felipe; Vizoso, Miguel; Kasper, Maria; Sansom, Owen J; Snippert, Hugo J; Liberali, Prisca; Simons, Benjamin D; Katajisto, Pekka; Hannezo, Edouard; van Rheenen, Jacco.

Nature ; 607(7919): 548-554, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35831497

3.

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Faller, William J; Jackson, Thomas J; Knight, John Rp; Ridgway, Rachel A; Jamieson, Thomas; Karim, Saadia A; Jones, Carolyn; Radulescu, Sorina; Huels, David J; Myant, Kevin B; Dudek, Kate M; Casey, Helen A; Scopelliti, Alessandro; Cordero, Julia B; Vidal, Marcos; Pende, Mario; Ryazanov, Alexey G; Sonenberg, Nahum; Meyuhas, Oded; Hall, Michael N; Bushell, Martin; Willis, Anne E; Sansom, Owen J.

Nature ; 517(7535): 497-500, 2015 Jan 22.

Artículo en Inglés | MEDLINE | ID: mdl-25383520

4.

E-cadherin can limit the transforming properties of activating ß-catenin mutations.

Huels, David J; Ridgway, Rachel A; Radulescu, Sorina; Leushacke, Marc; Campbell, Andrew D; Biswas, Sujata; Leedham, Simon; Serra, Stefano; Chetty, Runjan; Moreaux, Guenievre; Parry, Lee; Matthews, James; Song, Fei; Hedley, Ann; Kalna, Gabriela; Ceteci, Fatih; Reed, Karen R; Meniel, Valerie S; Maguire, Aoife; Doyle, Brendan; Söderberg, Ola; Barker, Nick; Watson, Alastair; Larue, Lionel; Clarke, Alan R; Sansom, Owen J.

EMBO J ; 34(18): 2321-33, 2015 Sep 14.

Artículo en Inglés | MEDLINE | ID: mdl-26240067

5.

Intestinal organoid co-culture protocol to study cell competition in vitro.

van Neerven, Sanne M; Ramadan, Rana; van Driel, Milou S; Huels, David J; Vermeulen, Louis.

STAR Protoc ; 3(1): 101050, 2022 03 18.

Artículo en Inglés | MEDLINE | ID: mdl-34977689

6.

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.

Ramadan, Rana; Wouters, Valérie M; van Neerven, Sanne M; de Groot, Nina E; Garcia, Tania Martins; Muncan, Vanessa; Franklin, Olivia D; Battle, Michelle; Carlson, Karen Sue; Leach, Joshua; Sansom, Owen J; Boulard, Olivier; Chamaillard, Mathias; Vermeulen, Louis; Medema, Jan Paul; Huels, David J.

Biol Open ; 11(12)2022 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-36350252

7.

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.

Vasquez, Ester Gil; Nasreddin, Nadia; Valbuena, Gabriel N; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Eggington, Holly R; Schenck, Ryan O; Wouters, Valérie M; Wirapati, Pratyaksha; Gilroy, Kathryn; Lannagan, Tamsin R M; Flanagan, Dustin J; Najumudeen, Arafath K; Omwenga, Sulochana; McCorry, Amy M B; Easton, Alistair; Koelzer, Viktor H; East, James E; Morton, Dion; Trusolino, Livio; Maughan, Timothy; Campbell, Andrew D; Loughrey, Maurice B; Dunne, Philip D; Tsantoulis, Petros; Huels, David J; Tejpar, Sabine; Sansom, Owen J; Leedham, Simon J.

Cell Stem Cell ; 29(8): 1213-1228.e8, 2022 08 04.

Artículo en Inglés | MEDLINE | ID: mdl-35931031

8.

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition.

Recasens-Alvarez, Carles; Alexandre, Cyrille; Kirkpatrick, Joanna; Nojima, Hisashi; Huels, David J; Snijders, Ambrosius P; Vincent, Jean-Paul.

Nat Cell Biol ; 23(2): 127-135, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33495632

9.

Oncogenic BRAF, unrestrained by TGFß-receptor signalling, drives right-sided colonic tumorigenesis.

Leach, Joshua D G; Vlahov, Nikola; Tsantoulis, Petros; Ridgway, Rachel A; Flanagan, Dustin J; Gilroy, Kathryn; Sphyris, Nathalie; Vázquez, Ester G; Vincent, David F; Faller, William J; Hodder, Michael C; Raven, Alexander; Fey, Sigrid; Najumudeen, Arafath K; Strathdee, Douglas; Nixon, Colin; Hughes, Mark; Clark, William; Shaw, Robin; van Hooff, Sander R; Huels, David J; Medema, Jan Paul; Barry, Simon T; Frame, Margaret C; Unciti-Broceta, Asier; Leedham, Simon J; Inman, Gareth J; Jackstadt, Rene; Thompson, Barry J; Campbell, Andrew D; Tejpar, Sabine; Sansom, Owen J.

Nat Commun ; 12(1): 3464, 2021 06 08.

Artículo en Inglés | MEDLINE | ID: mdl-34103493

10.

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Gay, David M; Ridgway, Rachel A; Müller, Miryam; Hodder, Michael C; Hedley, Ann; Clark, William; Leach, Joshua D; Jackstadt, Rene; Nixon, Colin; Huels, David J; Campbell, Andrew D; Bird, Thomas G; Sansom, Owen J.

Nat Commun ; 10(1): 1453, 2019 03 26.

Artículo en Inglés | MEDLINE | ID: mdl-30914643

11.

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Gay, David M; Ridgway, Rachel A; Müller, Miryam; Hodder, Michael C; Hedley, Ann; Clark, William; Leach, Joshua D; Jackstadt, Rene; Nixon, Colin; Huels, David J; Campbell, Andrew D; Bird, Thomas G; Sansom, Owen J.

Nat Commun ; 10(1): 723, 2019 02 13.

Artículo en Inglés | MEDLINE | ID: mdl-30760720

12.

Think About the Environment: Cellular Reprogramming by the Extracellular Matrix.

Huels, David J; Medema, Jan Paul.

Cell Stem Cell ; 22(1): 7-9, 2018 01 04.

Artículo en Inglés | MEDLINE | ID: mdl-29304343

13.

R-spondin Is More Than Just Wnt's Sidekick.

Huels, David J; Sansom, Owen J.

Dev Cell ; 41(5): 456-458, 2017 06 05.

Artículo en Inglés | MEDLINE | ID: mdl-28586642

14.

TGFß pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.

Cammareri, Patrizia; Vincent, David F; Hodder, Michael C; Ridgway, Rachel A; Murgia, Claudio; Nobis, Max; Campbell, Andrew D; Varga, Julia; Huels, David J; Subramani, Chithra; Prescott, Katie L H; Nixon, Colin; Hedley, Ann; Barry, Simon T; Greten, Florian R; Inman, Gareth J; Sansom, Owen J.

Cell Death Differ ; 24(10): 1681-1693, 2017 10.

Artículo en Inglés | MEDLINE | ID: mdl-28622298

15.

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.

Gil Vazquez, Ester; Nasreddin, Nadia; Valbuena, Gabriel N; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Eggington, Holly R; Schenck, Ryan O; Wouters, Valérie M; Wirapati, Pratyaksha; Gilroy, Kathryn; Lannagan, Tamsin R M; Flanagan, Dustin J; Najumudeen, Arafath K; Omwenga, Sulochana; McCorry, Amy M B; Easton, Alistair; Koelzer, Viktor H; East, James E; Morton, Dion; Trusolino, Livio; Maughan, Timothy; Campbell, Andrew D; Loughrey, Maurice B; Dunne, Philip D; Tsantoulis, Petros; Huels, David J; Tejpar, Sabine; Sansom, Owen J; Leedham, Simon J.

Cell Stem Cell ; 29(11): 1612, 2022 Nov 03.

Artículo en Inglés | MEDLINE | ID: mdl-36332574

16.

The APC network regulates the removal of mutated cells from colonic crypts.

Song, Je-Hoon; Huels, David J; Ridgway, Rachel A; Sansom, Owen J; Kholodenko, Boris N; Kolch, Walter; Cho, Kwang-Hyun.

Cell Rep ; 7(1): 94-103, 2014 Apr 10.

Artículo en Inglés | MEDLINE | ID: mdl-24685131

17.

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues.

Johnsson, Anna-Karin E; Dai, Yanfeng; Nobis, Max; Baker, Martin J; McGhee, Ewan J; Walker, Simon; Schwarz, Juliane P; Kadir, Shereen; Morton, Jennifer P; Myant, Kevin B; Huels, David J; Segonds-Pichon, Anne; Sansom, Owen J; Anderson, Kurt I; Timpson, Paul; Welch, Heidi C E.

Cell Rep ; 6(6): 1153-1164, 2014 Mar 27.

Artículo en Inglés | MEDLINE | ID: mdl-24630994

18.

Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis.

Huels, David J; Cammareri, Patrizia; Ridgway, Rachel A; Medema, Jan P; Sansom, Owen J.

Methods Mol Biol ; 1012: 237-48, 2013.

Artículo en Inglés | MEDLINE | ID: mdl-24006069

19.

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.

Myant, Kevin B; Cammareri, Patrizia; McGhee, Ewan J; Ridgway, Rachel A; Huels, David J; Cordero, Julia B; Schwitalla, Sarah; Kalna, Gabriela; Ogg, Erinn-Lee; Athineos, Dimitris; Timpson, Paul; Vidal, Marcos; Murray, Graeme I; Greten, Florian R; Anderson, Kurt I; Sansom, Owen J.

Cell Stem Cell ; 12(6): 761-73, 2013 Jun 06.

Artículo en Inglés | MEDLINE | ID: mdl-23665120

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Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

Retrograde movements determine effective stem cell numbers in the intestine.

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

E-cadherin can limit the transforming properties of activating ß-catenin mutations.

Intestinal organoid co-culture protocol to study cell competition in vitro.

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition.

Oncogenic BRAF, unrestrained by TGFß-receptor signalling, drives right-sided colonic tumorigenesis.

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Think About the Environment: Cellular Reprogramming by the Extracellular Matrix.

R-spondin Is More Than Just Wnt's Sidekick.

TGFß pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.

The APC network regulates the removal of mutated cells from colonic crypts.

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues.

Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis.

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.