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1.

Regulation of GTPase function by autophosphorylation.

Johnson, Christian W; Seo, Hyuk-Soo; Terrell, Elizabeth M; Yang, Moon-Hee; KleinJan, Fenneke; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M C; Geffken, Ezekiel A; Lakhani, Jimit; Song, Kijun; Bashyal, Puspalata; Popow, Olesja; Paulo, Joao A; Liu, Andrea; Mattos, Carla; Marshall, Christopher B; Ikura, Mitsuhiko; Morrison, Deborah K; Dhe-Paganon, Sirano; Haigis, Kevin M.

Mol Cell ; 82(5): 950-968.e14, 2022 03 03.

Artículo en Inglés | MEDLINE | ID: mdl-35202574

2.

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

Findlay, Greg M; Smith, Matthew J; Lanner, Fredrik; Hsiung, Marilyn S; Gish, Gerald D; Petsalaki, Evangelia; Cockburn, Katie; Kaneko, Tomonori; Huang, Haiming; Bagshaw, Richard D; Ketela, Troy; Tucholska, Monika; Taylor, Lorne; Bowtell, David D; Moffat, Jason; Ikura, Mitsuhiko; Li, Shawn S C; Sidhu, Sachdev S; Rossant, Janet; Pawson, Tony.

Cell ; 152(5): 1008-20, 2013 Feb 28.

Artículo en Inglés | MEDLINE | ID: mdl-23452850

3.

Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.

Ishiyama, Noboru; Lee, Seung-Hye; Liu, Shuang; Li, Guang-Yao; Smith, Matthew J; Reichardt, Louis F; Ikura, Mitsuhiko.

Cell ; 141(1): 117-28, 2010 Apr 02.

Artículo en Inglés | MEDLINE | ID: mdl-20371349

4.

Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin.

Duong, Cao Nguyen; Brückner, Randy; Schmitt, Martina; Nottebaum, Astrid F; Braun, Laura J; Meyer Zu Brickwedde, Marika; Ipe, Ute; Vom Bruch, Hermann; Schöler, Hans R; Trapani, Giuseppe; Trappmann, Britta; Ebrahimkutty, Mirsana P; Huveneers, Stephan; de Rooij, Johan; Ishiyama, Noboru; Ikura, Mitsuhiko; Vestweber, Dietmar.

J Cell Sci ; 134(24)2021 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-34851405

5.

The p.E152K-STIM1 mutation deregulates Ca²⁺ signaling contributing to chronic pancreatitis.

Burgos, Miguel; Philippe, Reginald; Antigny, Fabrice; Buscaglia, Paul; Masson, Emmanuelle; Mukherjee, Sreya; Dubar, Pauline; Le Maréchal, Cédric; Campeotto, Florence; Lebonvallet, Nicolas; Frieden, Maud; Llopis, Juan; Domingo, Beatriz; Stathopulos, Peter B; Ikura, Mitsuhiko; Brooks, Wesley; Guida, Wayne; Chen, Jian-Min; Ferec, Claude; Capiod, Thierry; Mignen, Olivier.

J Cell Sci ; 134(3)2021 02 10.

Artículo en Inglés | MEDLINE | ID: mdl-33468626

6.

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Saitoh, Takashi; Kim, Ha-Neul; Narita, Riku; Ohtsuka, Ibuki; Mo, Weiyu; Lee, Ki-Young; Enomoto, Masahiro; Gasmi-Seabrook, Geneviève M C; Marshall, Christopher B; Ikura, Mitsuhiko.

Protein Expr Purif ; 212: 106361, 2023 12.

Artículo en Inglés | MEDLINE | ID: mdl-37652393

7.

Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.

Stathopulos, Peter B; Zheng, Le; Li, Guang-Yao; Plevin, Michael J; Ikura, Mitsuhiko.

Cell ; 135(1): 110-22, 2008 Oct 03.

Artículo en Inglés | MEDLINE | ID: mdl-18854159

8.

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.

Fang, Zhenhao; Lee, Ki-Young; Huo, Ku-Geng; Gasmi-Seabrook, Geneviève; Zheng, Le; Moghal, Nadeem; Tsao, Ming-Sound; Ikura, Mitsuhiko; Marshall, Christopher B.

Proc Natl Acad Sci U S A ; 117(22): 12101-12108, 2020 06 02.

Artículo en Inglés | MEDLINE | ID: mdl-32414921

9.

The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics.

Lee, Ki-Young; Ikura, Mitsuhiko; Marshall, Christopher B.

Angew Chem Int Ed Engl ; 62(18): e202218698, 2023 04 24.

Artículo en Inglés | MEDLINE | ID: mdl-36883374

10.

Largen: a molecular regulator of mammalian cell size control.

Yamamoto, Kazuo; Gandin, Valentina; Sasaki, Masato; McCracken, Susan; Li, Wanda; Silvester, Jennifer Liepa; Elia, Andrew J; Wang, Feng; Wakutani, Yosuke; Alexandrova, Roumiana; Oo, Yathor D; Mullen, Peter J; Inoue, Satoshi; Itsumi, Momoe; Lapin, Valentina; Haight, Jillian; Wakeham, Andrew; Shahinian, Arda; Ikura, Mitsuhiko; Topisirovic, Ivan; Sonenberg, Nahum; Mak, Tak W.

Mol Cell ; 53(6): 904-15, 2014 Mar 20.

Artículo en Inglés | MEDLINE | ID: mdl-24656129

11.

NMR in integrated biophysical drug discovery for RAS: past, present, and future.

Marshall, Christopher B; KleinJan, Fenneke; Gebregiworgis, Teklab; Lee, Ki-Young; Fang, Zhenhao; Eves, Ben J; Liu, Ningdi F; Gasmi-Seabrook, Geneviève M C; Enomoto, Masahiro; Ikura, Mitsuhiko.

J Biomol NMR ; 74(10-11): 531-554, 2020 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-32804298

12.

The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.

Yang, Ziqiang; Xue, Bin; Umitsu, Masataka; Ikura, Mitsuhiko; Muthuswamy, Senthil K; Neel, Benjamin G.

Mol Cell ; 47(3): 469-83, 2012 Aug 10.

Artículo en Inglés | MEDLINE | ID: mdl-22883624

13.

Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

Meiri, David; Marshall, Christopher B; Greeve, Melissa A; Kim, Bryan; Balan, Marc; Suarez, Fernando; Bakal, Chris; Wu, Chuanjin; Larose, Jose; Fine, Noah; Ikura, Mitsuhiko; Rottapel, Robert.

Mol Cell ; 45(5): 642-55, 2012 Mar 09.

Artículo en Inglés | MEDLINE | ID: mdl-22405273

14.

A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization.

Grant, Benjamin M M; Enomoto, Masahiro; Ikura, Mitsuhiko; Marshall, Christopher B.

Int J Mol Sci ; 21(8)2020 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-32326637

15.

Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.

Lee, Ki-Young; Fang, Zhenhao; Enomoto, Masahiro; Gasmi-Seabrook, Genevieve; Zheng, Le; Koide, Shohei; Ikura, Mitsuhiko; Marshall, Christopher B.

Angew Chem Int Ed Engl ; 59(27): 11037-11045, 2020 06 26.

Artículo en Inglés | MEDLINE | ID: mdl-32227412

16.

Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.

DeFalco, Thomas A; Marshall, Christopher B; Munro, Kim; Kang, Hong-Gu; Moeder, Wolfgang; Ikura, Mitsuhiko; Snedden, Wayne A; Yoshioka, Keiko.

Plant Cell ; 28(7): 1738-51, 2016 07.

Artículo en Inglés | MEDLINE | ID: mdl-27335451

17.

Hitting the hotspots.

Marshall, Christopher B; Ikura, Mitsuhiko.

Nat Chem Biol ; 18(6): 578-579, 2022 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-35314815

18.

Inhibition of RAS function through targeting an allosteric regulatory site.

Spencer-Smith, Russell; Koide, Akiko; Zhou, Yong; Eguchi, Raphael R; Sha, Fern; Gajwani, Priyanka; Santana, Dianicha; Gupta, Ankit; Jacobs, Miranda; Herrero-Garcia, Erika; Cobbert, Jacqueline; Lavoie, Hugo; Smith, Matthew; Rajakulendran, Thanashan; Dowdell, Evan; Okur, Mustafa Nazir; Dementieva, Irina; Sicheri, Frank; Therrien, Marc; Hancock, John F; Ikura, Mitsuhiko; Koide, Shohei; O'Bryan, John P.

Nat Chem Biol ; 13(1): 62-68, 2017 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-27820802

19.

Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.

Gebregiworgis, Teklab; Marshall, Christopher B; Nishikawa, Tadateru; Radulovich, Nikolina; Sandí, María-José; Fang, Zhenhao; Rottapel, Robert; Tsao, Ming-Sound; Ikura, Mitsuhiko.

J Am Chem Soc ; 140(13): 4473-4476, 2018 04 04.

Artículo en Inglés | MEDLINE | ID: mdl-29543440

20.

Structural and functional conservation of key domains in InsP3 and ryanodine receptors.

Seo, Min-Duk; Velamakanni, Saroj; Ishiyama, Noboru; Stathopulos, Peter B; Rossi, Ana M; Khan, Samir A; Dale, Philippa; Li, Congmin; Ames, James B; Ikura, Mitsuhiko; Taylor, Colin W.

Nature ; 483(7387): 108-12, 2012 Jan 29.

Artículo en Inglés | MEDLINE | ID: mdl-22286060

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