The use of factor Xa inhibitors following opening-wedge high tibial osteotomy for venous thromboembolism prophylaxis.

PURPOSE: This study aimed to investigate the incidence of venous thromboembolism (VTE) after medial opening-wedge high tibial osteotomy (OWHTO) and evaluate the efficacy and safety of edoxaban for the prevention of VTE in patients undergoing OWHTO. METHODS: A total of 139 patients with osteoarthritis or osteonecrosis undergoing OWHTO were enrolled in this prospective, randomized study. Four patients were excluded because of preoperatively diagnosed VTE, and 135 patients were divided into two groups-an edoxaban group and a non-edoxaban group-and underwent computed tomography venography on day 7 to check for postoperative VTE. Blood samples were taken on the day before OWHTO and on postoperative days 1, 3, 7, and 14. RESULTS: Treatment with edoxaban reduced the incidence of VTE after OWHTO; however, there was no statistically significant difference between the two groups. No major bleeding was noted in the edoxaban group. There were significant differences in the D-dimer level, prothrombin time, fibrinogen level, and thrombin antithrombin complex levels between the groups. CONCLUSIONS: Edoxaban is an oral, once-daily, selective, direct factor Xa inhibitor that is safe and easy to handle. It may offer a new option for preventing VTE after OWHTO. LEVEL OF EVIDENCE: I.

The surgical epicondylar axis is a consistent reference of the distal femur in the coronal and axial planes.

PURPOSE: Various rotational landmarks including the surgical epicondylar axis (SEA) are used for preoperative planning and intra-operative reference of total knee arthroplasty (TKA) in the axial plane. The aim of the study was to elucidate the relationships between the SEA and other femoral anatomical landmarks, including the mechanical axis, distal and posterior knee joints, the trochlear groove, and the anterior femoral condyle, in both the coronal and axial planes. METHODS: Angular and linear measurements were taken of sixty femora using Orthomap3D, which has a tool to analyse computed tomography image data that makes it possible to measure three-dimensional distances and angles precisely. The inter- and intra-observer reliabilities of these measurements were evaluated. Comparisons were made according to height, weight, body mass index, and gender. RESULTS: The angle between the mechanical axis and the SEA was 90.2° (95% CI 90.0°-90.4°). There was a significant correlation for each linear measurement between the SEA and the distal/posterior knee joint line and for each linear measurement between the SEA and the anterior medial/lateral femoral condyle. A significant difference was observed between genders in the linear measurements. Significant correlations were found between height and weight and linear parameters. CONCLUSION: Knowledge of the relationships between the SEA and other femoral anatomical landmarks is useful in preoperative planning, intra-operative landmark, and postoperative assessment of TKA. The SEA is a consistent parameter of femoral alignment in the coronal plane and a stable reference for femoral rotation in the axial plane. LEVEL OF EVIDENCE: III.