RESUMEN
Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminoquinones, and nitroheterocycles. Reductions usually were in the favorable range of +0.2 to -0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the catalytic production of oxidative stress or disruption of helminth electron transport systems. Relevant literature results are discussed.
Asunto(s)
Antihelmínticos , Animales , Antihelmínticos/farmacología , Antimonio , Arsénico/farmacología , Bencimidazoles/farmacología , Biguanidas/farmacología , Tetracloruro de Carbono/farmacología , Fenómenos Químicos , Química , Colorantes/farmacología , Electroquímica , Helmintos/efectos de los fármacos , Hidrazonas/farmacología , Nitrocompuestos/farmacología , Oxidación-Reducción , Peróxidos/farmacología , Fenotiazinas/farmacología , Piridinas/farmacología , Quinonas/farmacología , Relación Estructura-ActividadRESUMEN
A series of 13 new 1,1-diphenylacetic acid derivatives was synthesized via common transformations of 2-phenyl-2-(p-nitrophenyl) propio- and butyronitriles. The compounds were submitted to pharmacological screening. 2-Phenyl-2-(p-aminophenyl)propionamide (VIII) showed high anticonvulsant activity.