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1.
Zhonghua Nan Ke Xue ; 28(8): 711-714, 2022 Aug.
Artículo en Zh | MEDLINE | ID: mdl-37838971

RESUMEN

OBJECTIVE: To observe the clinical effect of Manlyman Spray in the treatment of premature ejaculation (PE). METHODS: From January 2021 to March 2022, a total of 123 patients with PE were enrolled in clinical observation. Manlyman Spray was sprayed on the surface of the glans penis, corona of the glans and frenulum of the penis qd for 4 weeks. Before and after medication and at 4 weeks after drug withdrawal, the intravaginal ejaculation latency time (IELT), Premature Ejaculation Diagnostic Tool (PEDT) scores and Chinese Index of Sexual Function for Premature Ejaculation (ClPE) scores of the patients were obtained and compared. RESULTS: Compared with the baseline, the IELT of the patients was significantly prolonged after 4 weeks of medication (ï¼»1.51 ± 0.42ï¼½ vs ï¼»3.79 ± 1.69ï¼½ min, P < 0.05) and at 4 weeks after drug withdrawal (ï¼»1.51 ± 0.42ï¼½ vs ï¼»3.55 ± 1.62ï¼½ min, P < 0.05), the PEDT scores were remarkably improved after 4 weeks of medication (14.0 ± 1.9 vs 7.7 ± 2.1, P < 0.05) and at 4 weeks after drug withdrawal (14.0 ± 1.9 vs 7.8 ± 2.0, P < 0.05), and so were the CIPE scores (9.0 ± 1.6 vs 20.0 ± 1.7, P < 0.05, and 9.0 ± 1.6 vs 17.3 ± 1.6, P < 0.05). CONCLUSION: Manlyman Spray has a definite effect in the treatment of PE.


Asunto(s)
Eyaculación Prematura , Masculino , Humanos , Eyaculación Prematura/tratamiento farmacológico , Eyaculación , Resultado del Tratamiento , Pene
2.
Zhonghua Nan Ke Xue ; 26(2): 154-159, 2020 Feb.
Artículo en Zh | MEDLINE | ID: mdl-33346420

RESUMEN

OBJECTIVE: To investigate the significance of cytogenetic and molecular genetic diagnosis of a special type of secondary sexual dysplasia and the applicability of various methods for its detection. METHODS: Using karyotype analysis, array comparative genomic hybridization (aCGH), multiplex ligation-dependent probe amplification (MLPA) and methylation-specific PCR (MS-PCR), we diagnosed and differentially diagnosed a case of secondary sexual dysplasia. RESULTS: Abnormalities were not found in the karyotype analysis or the SRY and AZF gene detection, nor chromosomal duplication and deletion in the initial SurePrint G3 Human CGH Array Kit8×60K.SurePrint G3 unrestricteda CGH ISCA v2,88×60K, however, identified a 68.9 kb deletion of chromosome 15 (hg19:25190737-25259677). MLPA revealed the deletion of exon 3 of the SNRPN gene. MS-PCR showed a significant decrease in the paternal fragment signals, but no difference in the maternal fragment signals between the sample from the patient and that from the control. CONCLUSIONS: The patient was confirmed with Prader-Willi syndrome by various methods of detection.


Asunto(s)
Síndrome de Prader-Willi , Hibridación Genómica Comparativa , Metilación de ADN , Exones , Humanos , Cariotipificación , Síndrome de Prader-Willi/diagnóstico , Síndrome de Prader-Willi/genética , Eliminación de Secuencia , Proteínas Nucleares snRNP/genética
3.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 34(2): 240-243, 2017 Apr 10.
Artículo en Zh | MEDLINE | ID: mdl-28397228

RESUMEN

OBJECTIVE: To use combined G-banding and array-comparative genomic hybridization (aCGH) for the prenatal diagnosis of a fetus with 5q35 deletion syndrome. METHODS: Chromosomal karotypes of the fetus and parents were analyzed with G-banding analysis. aCGH was performed to detect minor chromosomal structural abnormalities. RESULTS: The karyotype of the fetus was ascertained as 46, XY, t(5;10)(q35;p13), and the karyotypes of the parents were normal. aCGH has identified a de novo 1.68 Mb deletion at 5q35.2q35.3 and a 1.44 Mb duplication at 10p14p13. CONCLUSION: aCGH has a higher resolution and greater accuracy for mapping chromosomal aberrations and is a useful supplement for G banding karyptyping analysis.


Asunto(s)
Síndrome del Maullido del Gato/genética , Enfermedades Fetales/genética , Trisomía/genética , Adulto , Bandeo Cromosómico , Deleción Cromosómica , Cromosomas Humanos Par 5/genética , Hibridación Genómica Comparativa , Síndrome del Maullido del Gato/diagnóstico , Síndrome del Maullido del Gato/embriología , Femenino , Enfermedades Fetales/diagnóstico , Humanos , Cariotipificación , Masculino , Diagnóstico Prenatal , Trisomía/diagnóstico
4.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 32(6): 866-70, 2015 Dec.
Artículo en Zh | MEDLINE | ID: mdl-26663067

RESUMEN

OBJECTIVE: To explore the possible roles of polymorphisms of SPO11 and glutathionine S-transferase (GST) genes in idiopathic male infertility in a ethnic Han Chinese population from Henan. METHODS: Multiplex PCR and DNA sequencing were performed to determine the SPO11 c.517C>T(rs28368082) and GST genes (GSTM1, GSTT1, GSTP1) polymorphisms in 216 idiopathic male infertility cases and 198 normal samples. RESULTS: The frequencies of the SPO11 CC and CT genotypes were 87.5% (189/216) and 12.5% (27/216) in the patients, and 97.5% (193/198) and 2.5% (5/198) in the controls, respectively. The frequencies of SPO11 CC and CT genotypes, the A>G transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the frequencies of combined genotypes GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) were significantly different between the two groups (P<0.05). CONCLUSION: The rs28368082 polymorphism of the SPO11 gene, the A>G transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the combined genotypes of GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese.


Asunto(s)
Endodesoxirribonucleasas/genética , Predisposición Genética a la Enfermedad/genética , Gutatión-S-Transferasa pi/genética , Glutatión Transferasa/genética , Infertilidad Masculina/genética , Polimorfismo Genético , Adulto , Alelos , Pueblo Asiatico/genética , Secuencia de Bases , China , Frecuencia de los Genes , Predisposición Genética a la Enfermedad/etnología , Genotipo , Humanos , Infertilidad Masculina/enzimología , Infertilidad Masculina/etnología , Desequilibrio de Ligamiento , Masculino , Mutación , Oportunidad Relativa , Análisis de Secuencia de ADN
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