RESUMEN
Idiopathic facial aseptic granuloma (IFAG) is a condition that is commonly encountered in clinical practice, but is rarely reported. It appears in childhood and its pathogenesis is still unknown. It has a benign course with resolution within a few months without aggressive treatment. Microbiological tests are negative and histological findings are nonspecific. It is possible that this condition is part of the spectrum of granulomatous rosacea in childhood. We present two cases in which diagnosis of IFAG was established and resolved without sequelae following topical antibiotic treatment.
Asunto(s)
Dermatosis Facial/patología , Granuloma/patología , Adolescente , Niño , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Rosácea/patologíaRESUMEN
BACKGROUND AND OBJECTIVE: In the latest edition of its cancer staging manual, the American Joint Committee on Cancer (AJCC) revised the criteria for staging squamous cell carcinoma (SCC) by introducing high-risk tumor features to define tumor stage (T) and help to identify tumors with a higher risk of metastasis. The aim of this study was to investigate the characteristics associated with SCC meeting the high-risk criteria defined by the AJCC for T2 lesions. PATIENTS AND METHOD: We performed a case-case observational study in which patients with SCC were included over a period of 18 months. We collected clinical, anthropometric, and tumor data, and analyzed these using PASW Statistics (SPSS) version 18. RESULTS: One-hundred eighteen patients, the majority of whom were men, were included. Mean age was 77 years. Over 70% of the tumors were located in the head region and a majority of tumors measured 2 cm or less. The prevalence of SCC T2 was 61.9%. The risk factors significantly associated with SCC T2 were an age of over 85 years (odds ratio [OR], 4.48), location in the head and neck region (OR, 3.38), presence of solar elastosis in the peritumoral tissue (OR, 2.08), a higher tumor growth rate (>1.5 mm·wk(-1); OR, 5.73), and higher cumulative exposure to smoking (>20 pack-years, OR, 3.63). CONCLUSIONS: Advanced age, location in the head and neck region, presence of solar elastosis, high tumor growth rate, and high cumulative smoking exposure were all significantly associated with the presence of SCC T2.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias Cutáneas/patología , Factores de Edad , Anciano , Anciano de 80 o más Años , Antropometría , Carcinoma de Células Escamosas/epidemiología , Comorbilidad , Femenino , Neoplasias de Cabeza y Cuello/epidemiología , Neoplasias de Cabeza y Cuello/patología , Humanos , Queratosis Actínica/epidemiología , Masculino , Estadificación de Neoplasias , Neoplasias Inducidas por Radiación/patología , Factores de Riesgo , Neoplasias Cutáneas/epidemiología , Pigmentación de la Piel , Fumar/efectos adversos , Fumar/epidemiología , España/epidemiología , Carga TumoralRESUMEN
Local anesthetics are widely used in clinical practice, and adverse effects are not uncommon. Delayed hypersensitivity reactions are among the most common effects, but immediate-type reactions may also occur. Patch testing should be considered in patients with hypersensitivity reactions. We present a case of allergic contact dermatitis to benzocaine that was detected incidentally by patch testing and highlight the importance of correctly interpreting patch test results when there are concomitant positive reactions.
Asunto(s)
Anestésicos Locales/efectos adversos , Benzocaína/efectos adversos , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/etiología , Pruebas del Parche , Femenino , Humanos , Persona de Mediana EdadAsunto(s)
Esclerodermia Localizada/patología , Enfermedades Cutáneas Vesiculoampollosas/patología , Diagnóstico Diferencial , Femenino , Hemorragia/etiología , Humanos , Pierna , Traumatismos de la Pierna/complicaciones , Linfangiectasia , Persona de Mediana Edad , Modelos Biológicos , Esclerodermia Localizada/diagnóstico , Esclerodermia Localizada/etiología , Enfermedades Cutáneas Vesiculoampollosas/diagnóstico , Enfermedades Cutáneas Vesiculoampollosas/etiologíaAsunto(s)
Escisión del Ganglio Linfático/efectos adversos , Linfedema/complicaciones , Complicaciones Posoperatorias/etiología , Síndrome de Sweet/etiología , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/radioterapia , Neoplasias de la Mama/cirugía , Carcinoma Ductal de Mama/tratamiento farmacológico , Carcinoma Ductal de Mama/radioterapia , Carcinoma Ductal de Mama/cirugía , Quimioterapia Adyuvante , Terapia Combinada , Diagnóstico Diferencial , Femenino , Humanos , Mastectomía Segmentaria , Persona de Mediana Edad , Radiodermatitis/diagnóstico , Radioterapia Adyuvante , Enfermedades Cutáneas Infecciosas/diagnóstico , Síndrome de Sweet/diagnósticoAsunto(s)
Carcinoma de Células Escamosas/diagnóstico , Queratoacantoma/diagnóstico , Enfermedades de la Uña/diagnóstico , Neoplasias Cutáneas/diagnóstico , Adulto , Diagnóstico Diferencial , Femenino , Dedos , Humanos , Queratoacantoma/patología , Queratoacantoma/cirugía , Enfermedades de la Uña/patología , Enfermedades de la Uña/cirugíaAsunto(s)
Edema/etiología , Espasmo Hemifacial/complicaciones , Enfermedades de los Labios/etiología , Anciano , Biopsia , Diagnóstico Diferencial , Edema/patología , Femenino , Espasmo Hemifacial/diagnóstico , Humanos , Enfermedades de los Labios/patología , Síndrome de Melkersson-Rosenthal/diagnósticoRESUMEN
Eruptive melanocytic nevi have mainly been associated with blistering cutaneous diseases and with immunosuppression, particularly after renal allograft transplantation, hematological neoplasms, or HIV infection. Thus, immunosuppression has been suggested to increase the possibility of melanocyte proliferation. We report two cases of children with acute lymphoblastic leukemia who, after receiving chemotherapy, developed severe motor polyneuropathy, and sudden onset of multiple melanocytic nevi on the soles.
Asunto(s)
Antineoplásicos/efectos adversos , Enfermedades del Pie/inducido químicamente , Nevo/inducido químicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Neoplasias Cutáneas/inducido químicamente , Niño , Preescolar , Femenino , Humanos , MasculinoRESUMEN
The authors studied the oligosaccharides coated membrane of normal keratinocytes with the lectins HPA, PHA-L, RCA-120; and ConA. The results permit to have a pattern of normally epidermic differentiation.
Asunto(s)
Epidermis/ultraestructura , Lectinas , Oligosacáridos/análisis , Diferenciación Celular , Membrana Celular/análisis , Humanos , Queratinas/biosíntesisRESUMEN
The authors study a case of Hodgkin's disease type Rye III with specific infiltration of the skin. In cutaneous biopsy we find Reed-Stenberg cells. With treatment the cutaneous lesion diminishes without disappearing. A discussion is made about the Hodgkin's disease and its relation with lymphomatoid papulosis and its differential diagnostic with cutaneous lymphomas and the pathogenic way of cutaneous infiltration.
Asunto(s)
Enfermedad de Hodgkin/patología , Neoplasias Cutáneas/patología , Diagnóstico Diferencial , Humanos , Linfoma/patología , Masculino , Persona de Mediana EdadRESUMEN
Eosinophilic fasciitis is a syndrome of imprecise classification which usually responds well to corticosteroids. We report a patient who did not respond to such treatment but he improved with cimetidine therapy. The pathogenesis of this syndrome and the possible action mechanism of cimetidine are discussed.
Asunto(s)
Cimetidina/uso terapéutico , Eosinofilia/tratamiento farmacológico , Fascitis/tratamiento farmacológico , Cimetidina/farmacología , Eosinofilia/patología , Fascitis/patología , Liberación de Histamina/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Prednisona/uso terapéuticoRESUMEN
The authors study four cases of Sweet's syndrome in which the clinical manifestations differ from the original description, although the laboratory reports, the response to the treatment and histologic data were typical of this entity. By the way, the authors propose a hypothesis about the pathogenesis of this syndrome.
Asunto(s)
Dermatitis Exfoliativa/etiología , Edema/etiología , Neutrófilos/patología , Enfermedades de la Piel/patología , Adulto , Dermatitis Exfoliativa/patología , Edema/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , SíndromeRESUMEN
Kawasaki syndrome is not usual in our country. We report this case to stress the clinical importance of this syndrome in which dermatological signs predominate.