Clinical Course and Outcome of ESRD Patients on Maintenance Hemodialysis Infected with COVID-19: A Single-Center Study.

BACKGROUND: In an ESRD subset of patients, COVID-19 infection is associated with increased disease burden and higher mortality rates. METHODS: We conducted a retrospective single-center cohort study in which 43 ESRD patients had a diagnosis of COVID-19. Association of risk factors with mortality was assessed by chi-square test and logistic regression analysis. Data were collected on a structured performa which included variables like age, gender, comorbid conditions, drug history, clinical presentation, hemodynamic status and laboratory parameters. Outcome variables were recovery and death. All patients received standard treatment for COVID-19 according to hospital protocols, along with hemodialysis and continuous renal replacement therapy (CRRT) when needed. RESULTS: Those most affected were found to be male, 25 (58.1%), while the number of females affected was 18 (41.9%). The most frequent comorbid condition was hypertension (HTN), seen in 35 (81.4%) patients; however, thromboembolic complications were very few in these patients. The mortality rate in our study was 25.6%, and the population most susceptible to poor outcomes in the ESRD subgroup was elderly people (45.5%), while younger patients recovered the most from COVID-19 (53.1%). Hypoalbuminemia, leukocytosis, lymphopenia and raised LDH were also found to be associated with death in ESRD patients suffering from COVID-19 (81.8, 72.7, 100 and 100%, respectively). In multivariate logistic regression analysis, we found that the odds ratio of dying from COVID-19 was 19.5 times higher in patients aged >65 years as compared to patients aged 18-50 years (p=0.039). Similarly, patients with a high TLC were 24.1 times more likely to die than patients with a normal TLC (p=0.008). CONCLUSION: In our center, the mortality rate of ESRD patients affected with COVID-19 disease was 25.6%, and older age, leukocytosis, lymphopenia, hypoalbuminemia and high LDH were significantly associated with mortality.

Mesenchymal neoplasms of the head and neck: a cytopathologic analysis on fine needle aspiration.

INTRODUCTION: Fine-needle aspiration (FNA) is commonly used to diagnose mass lesions discovered in the head and neck (H&N). Soft tissue neoplasms (STNs) are less common than epithelial tumors in this anatomic zone and often cause diagnostic difficulty when encountered in routine practice. In this study, we examine the frequency of H&N STNs at our institution and describe their cytomorphologic characteristics and clinical correlates. METHODS: 115 FNA specimens from 115 patients with STN of the H&N region were identified (2005-2015) from archives of The Johns Hopkins University Hospital. When available, slides from these cases were reviewed and any corresponding clinical and radiologic data was evaluated. RESULTS: A total of 95 (83%) STNs were found to be primary to the H&N region and 20 (17%) were metastatic from distant sites. Of these 95 cases, 58 (61%) primary lesions were benign and 37 (39%) were malignant. The most common STNs were benign nerve sheath tumors, representing 40 (35%) cases: 30 schwannomas, 4 neurofibromas, and 6 were not further classified. The most aggressive neoplasms in terms of clinical outcome were leiomyosarcoma, Ewing sarcoma, synovial sarcoma, and chondrosarcoma. In 35 (60%) of the malignant cases and 25 (54%) of the benign cases a subsequent surgical resection was performed. CONCLUSIONS: H&N can be involved by a wide range of primary and metastatic STNs. benign nerve sheath tumors are the most common STNs found on FNA in this region. Although not always definitively diagnostic, FNA of STNs can often provide a differential diagnosis that can help guide the need for an excision and/or further treatment.