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1.
Electrophoresis ; 41(12): 1081-1094, 2020 06.
Artículo en Inglés | MEDLINE | ID: mdl-32103511

RESUMEN

Microfluidic system, or lab-on-a-chip, has grown explosively. This system has been used in research for the first time and then entered in the clinical section. Due to economic reasons, this technique has been used for screening of laboratory and clinical indices. The microfluidic system solves some difficulties accompanied by clinical and biological applications. In this review, the interpretation and analysis of some recent developments in microfluidic systems in biomedical applications with more emphasis on tissue engineering and cancer will be discussed. Moreover, we try to discuss the features and functions of microfluidic systems.


Asunto(s)
Dispositivos Laboratorio en un Chip , Técnicas Analíticas Microfluídicas , Neoplasias/diagnóstico , Ingeniería de Tejidos , Animales , Diseño de Equipo , Humanos , Ratones , Andamios del Tejido
2.
J Biomed Mater Res A ; 108(2): 221-233, 2020 02.
Artículo en Inglés | MEDLINE | ID: mdl-31581359

RESUMEN

The aim of this study was to synthesize an innovative composite scaffold, which structured of clinoptilolite-nanohydroxyapatite/chitosan-gelatin (CLN-nHA/CS-G) with enhanced attributes for utilization in the bone tissue engineering. This composite scaffold was prepared by blending the CLN, nHA, chitosan, and gelatin solution followed by a freeze-drying step. The fabricated composite scaffolds were studied using BET, FTIR, XRD, and SEM techniques. The highly porous composite scaffolds with a pore size of 200 ± 100 µm were synthesized. Moreover, the effects of CLN and nHA on the physicochemical features of the scaffold such as density, swelling ratio, biomineralization, biodegradation, and mechanical behavior were studied. Compared with CS-G scaffold, the presence of CLN and nHA leads to an increased surface area, increased biomineralization, and low rate of degradation in simulated body fluid solution (SBF) and mechanical strength. Cytotoxicity of the CLN-nHA/CS-G scaffold was studied by MTT assay on human dental pulp stem cells (h-DPSCs). The biological response of h-DPSCs showed no toxicity and studied cells proliferated and attached on the pore surfaces of the scaffold. Results indicated that introducing CLN and nHA to composite improves the scaffold characteristics in a way that makes it suitable for bone tissue engineering.


Asunto(s)
Materiales Biocompatibles/química , Quitosano/química , Durapatita/química , Gelatina/química , Andamios del Tejido/química , Zeolitas/química , Huesos/citología , Huesos/fisiología , Línea Celular , Proliferación Celular , Pulpa Dental/citología , Humanos , Células Madre/citología , Ingeniería de Tejidos
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