RESUMEN
BACKGROUND: Food allergy is a growing health problem worldwide because of its increasing prevalence, life-threatening potential, and shortage of effective preventive treatments. In an outbreak of wheat allergy in Japan, thousands of patients had allergic reactions to wheat after using soap containing hydrolyzed wheat protein (HWP). OBJECTIVES: The aim of the present study was to investigate genetic variation that can contribute to susceptibility to HWP allergy. METHODS: We conducted a genome-wide association study of HWP allergy in 452 cases and 2700 control subjects using 6.6 million genotyped or imputed single nucleotide polymorphisms. Replication was assessed by genotyping single nucleotide polymorphisms in independent samples comprising 45 patients with HWP allergy and 326 control subjects. RESULTS: Through the genome-wide association study, we identified significant associations with the class II HLA region on 6p21 (P = 2.16 × 10-24 for rs9271588 and P = 2.96 × 10-24 for HLA-DQα1 amino acid position 34) and with the RBFOX1 locus at 16p13 (rs74575857, P = 8.4 × 10-9). The associations were also confirmed in the replication data set. Both amino acid polymorphisms (HLA-DQß1 amino acid positions 13 and 26) located in the P4 binding pockets on the HLA-DQ molecule achieved the genome-wide significance level (P < 5.0 × 10-8). CONCLUSIONS: Our data provide the first demonstration of genetic risk for HWP allergy and show that this genetic risk is mainly represented by multiple combinations of HLA variants.
Asunto(s)
Genotipo , Antígenos HLA-DQ/genética , Factores de Empalme de ARN/genética , Hipersensibilidad al Trigo/genética , Alérgenos/inmunología , Antígenos de Plantas/inmunología , Brotes de Enfermedades , Femenino , Frecuencia de los Genes , Predisposición Genética a la Enfermedad , Estudio de Asociación del Genoma Completo , Humanos , Hidrólisis , Japón/epidemiología , Masculino , Persona de Mediana Edad , Polimorfismo de Nucleótido Simple , Triticum/inmunología , Hipersensibilidad al Trigo/epidemiologíaRESUMEN
Follicular mucinosis (alopecia mucinosa) is often associated with malignancies including mycosis fungoides and Sézary syndrome, but not adult T-cell leukemia-lymphoma (ATLL). We report a 49-year-old male patient who had pruritic follicular papules and erythemas clinically, and follicular and perifollicular infiltrates and follicular mucin deposition histopathologically. The patient showed 11% of flower-shaped atypical lymphocytes in blood examination and positive human T-cell leukemia virus type 1 antibody in serology, consistent with the chronic type of ATLL. This case seems to be a very rare association of follicular mucinosis and chronic ATLL, suggesting that malignant T cells may have a feature of folliculotropism as well as epidermotropism.
Asunto(s)
Leucemia-Linfoma de Células T del Adulto/complicaciones , Mucinosis Folicular/complicaciones , ADN Viral/genética , ADN Viral/aislamiento & purificación , Virus Linfotrópico T Tipo 1 Humano/genética , Virus Linfotrópico T Tipo 1 Humano/aislamiento & purificación , Humanos , Leucemia-Linfoma de Células T del Adulto/patología , Leucemia-Linfoma de Células T del Adulto/virología , Masculino , Persona de Mediana Edad , Mucinosis Folicular/patologíaRESUMEN
Povidone-iodine (polyvinylpyrrolidone-iodine, PVP-I) solution is an effective and safe disinfectant agent used throughout the world; however, prolonged exposure to PVP-I solution may cause irritation or rarely severe skin reactions. When PVP-I as is in the aqueous state is used for patch testing, a false-positive result is likely to arise due to irritation. Patch testing to exclude allergic contact dermatitis caused by PVP-I should be done with dried 10% PVP-I solution, 10% PVP-I gel, 8% sodium thiosulfuric acid and a mixture of 10% PVP-I solution and 8% sodium thiosulfuric acid.