Research trends in hypertension associated with obstructive sleep apnea: a bibliometric analysis.

OBJECTIVES: The purpose of this study was to systematically analyze the studies of hypertension associated with obstructive sleep apnea to assess the current status and hot spots in this field. METHODS: We searched the Web of Science Core Collection for publications related to hypertension associated with obstructive sleep apnea published before July 3, 2021. Bibliometric analyses and science mappings were carried out using the CiteSpace 5.8.R1 and Microsoft Office Excel 2019. CiteSpace 5.8.R1 was used to visualize the distribution of research fields, analyze co-occurring keywords and burst terms to detect trends and frontiers, and identify leading collaborations among countries, authors, and institutions. Microsoft Office Excel 2019 was used to make bar graphs, histograms and line graphs. RESULTS: According to the search strategy, a total of 7263 published articles and reviews were retrieved. The research on hypertension associated with obstructive sleep apnea has been developing quickly at present. Sleep and Breathing was the most productive journal. The USA was a major producing country and Harvard Medical School was the most productive institution in this field. In the field of hypertension associated with obstructive sleep apnea, the main research hotspots were continuous positive airway pressure, cardiovascular disease, and obesity. CONCLUSIONS: The present study provides a new perspective for the study of hypertension associated with obstructive sleep apnea and valuable information for researchers to find potential partners and cooperative institutions, hot issues and research frontiers.

Metastable helium Faraday filter for helium lidar to measure the density of the thermosphere.

We demonstrate a metastable helium Faraday optical filter operating on the 23S1 - 23P1 and 23S1 - 23P2 transition at 1083 nm by using a 3 cm long helium cell. The influence of the magnetic field and gas pressure of the helium cell on the filter characteristics is experimental studied. When the magnetic field is 230 Gs and the gas pressure of helium cell is about 110 Pa, the peak transmission corresponding to the two energy level transitions is about 32% and 57%, respectively. The equivalent noise bandwidth (ENBW) under this working condition is about 1.9 GHz. The metastable helium Faraday filter can be used to improve the optical inefficiency of a helium resonance fluorescence lidar to achieve the metastable helium density detection at 200-1000 km thermosphere.

Ultraviolet trifrequency Rayleigh DWL for stratosphere atmospheric wind measurements during the daytime based on an ultranarrow-bandwidth optical receiver.

An ultranarrow-bandwidth-optical-receiver-based ultraviolet trifrequency Rayleigh Doppler wind lidar (DWL) technology is proposed that is able to simultaneously detect stratospheric wind with high precision during the daytime. The lidar system is designed, and the principle of wind measurement is analyzed. An ultranarrow-bandwidth element used for suppressing strong background light is designed as an important part of the ultranarrow-bandwidth optical receiver. A three-channel Fabry-Perot interferometer (FPI) is capable of measuring wind speed. A non-polarized beam splitter cube optically contacted on the three-channel FPI can offer a stable splitting ratio. The parameters of the three-channel FPI are optimized. The structure and parameters of the ultranarrow-bandwidth element are designed, and the transmission curve is measured. The transmission curve and stability of the three-channel FPI are validated. The background photon number is collected with the ultranarrow-bandwidth element and with an interference filter (IF) alternately from 08:00 to 18:00. Based on the selected system parameters and measured background photon number, the detection performance of the proposed lidar is simulated. Simulation results show that with 200 m range resolution from 15 to 25 km, 500 m range resolution from 25 to 40 km, and 30 min total accumulation time for paired line-of-sight (LOS) measurement, within $\pm {100}\;{\rm m/s}$±100m/s LOS wind speed range, the daytime LOS wind speed error is below 4.77 m/s from 15 to 40 km altitude. Compared with the traditional IF-based dual-FPI Rayleigh Doppler lidar, the wind speed accuracies are improved by 1.29-16.29 times and the detection altitudes are improved from 23.55 to 40 km with the same wind-detecting precision.

The nutritional roles of zinc for immune system and COVID-19 patients.

Zinc (Zn) is a vital micronutrient that strengthens the immune system, aids cellular activities, and treats infectious diseases. A deficiency in Zn can lead to an imbalance in the immune system. This imbalance is particularly evident in severe deficiency cases, where there is a high susceptibility to various viral infections, including COVID-19 caused by SARS-CoV-2. This review article examines the nutritional roles of Zn in human health, the maintenance of Zn concentration, and Zn uptake. As Zn is an essential trace element that plays a critical role in the immune system and is necessary for immune cell function and cell signaling, the roles of Zn in the human immune system, immune cells, interleukins, and its role in SARS-CoV-2 infection are further discussed. In summary, this review paper encapsulates the nutritional role of Zn in the human immune system, with the hope of providing specific insights into Zn research.

A new strategy for enhanced electrochemically activation of persulfate on B and Co co-modified carbon felt in flow-through system for efficient organic pollutants degradation.

Electrochemical activation of persulfate (EA-PS) is gradually attracting attention as an emerging method for wastewater treatment. In this study, a novelty flow-through EA-PS system was first attempted for pollutants degradation using boron and cobalt co-doping carbon felt (B, Co-CF) as the cathode. SEM images, XPS and XRD spectra of B, Co-CF were investigated. The optimal doping ration between B and Co was 1:2. Increasing current density, PS concentration and flow rate, decreasing initial pH accelerated the removal of AO7. The mechanism involved in EA-PS were the comprehensive effect of DET, •OH and SO4•-. B, Co-CF cathode for flow-through system was stable with five cycles efficient AO7 decay performance. EA-PS in flow-through system was an efficient method with low cost and efficient pollutants degradation. This work provides a feasible strategy for synergistically enhancing PS activation and promoting the degradation of organic pollutants.

Extracellular Expression of Feruloyl Esterase and Xylanase in Escherichia coli for Ferulic Acid Production from Agricultural Residues.

There is still a large amount of ferulic acid (FA), an outstanding antioxidant, present in agricultural residues. Enzymatic hydrolysis has been regarded as the most effective way to release FA. This present study therefore selected feruloyl esterase (FAE) and xylanase (XYN) from the metagenomes of a cow rumen and a camel rumen, respectively, for their recombinant expression in Escherichia coli BL21 and further application in releasing FA. After screening the candidate signal peptides, the optimal one for each enzyme, which were selected as SP1 and SP4, respectively, was integrated into the vectors pET22b(+) and pETDuet-1. Among the generated E. coli strains SP1-F, SP4-X, and SP1-F-SP4-X that could express extracellular enzymes either separately or simultaneously, the latter one performed the best in relation to degrading the biomass and releasing FA. Under the optimized culture and induction conditions, the strain SP1-F-SP4-X released 90% of FA from 10% of de-starched wheat bran and produced 314.1 mg/L FA, which was deemed to be the highest obtained value to the best of our knowledge. This result could pave a way for the re-utilization of agricultural residues and enhancing their add-value.