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1.

A ciliary synapse for "short-circuit" neuromodulation.

Simon, David J; Levitz, Joshua.

Cell ; 185(18): 3284-3286, 2022 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-36055196

2.

An epigenetic barrier sets the timing of human neuronal maturation.

Ciceri, Gabriele; Baggiolini, Arianna; Cho, Hyein S; Kshirsagar, Meghana; Benito-Kwiecinski, Silvia; Walsh, Ryan M; Aromolaran, Kelly A; Gonzalez-Hernandez, Alberto J; Munguba, Hermany; Koo, So Yeon; Xu, Nan; Sevilla, Kaylin J; Goldstein, Peter A; Levitz, Joshua; Leslie, Christina S; Koche, Richard P; Studer, Lorenz.

Nature ; 626(8000): 881-890, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38297124

3.

Profiling the proximal proteome of the activated µ-opioid receptor.

Polacco, Benjamin J; Lobingier, Braden T; Blythe, Emily E; Abreu, Nohely; Khare, Prachi; Howard, Matthew K; Gonzalez-Hernandez, Alberto J; Xu, Jiewei; Li, Qiongyu; Novy, Brandon; Naing, Zun Zar Chi; Shoichet, Brian K; Coyote-Maestas, Willow; Levitz, Joshua; Krogan, Nevan J; Von Zastrow, Mark; Hüttenhain, Ruth.

Nat Chem Biol ; 2024 Mar 25.

Artículo en Inglés | MEDLINE | ID: mdl-38528119

4.

A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.

Chao, Luke H; Stratton, Margaret M; Lee, Il-Hyung; Rosenberg, Oren S; Levitz, Joshua; Mandell, Daniel J; Kortemme, Tanja; Groves, Jay T; Schulman, Howard; Kuriyan, John.

Cell ; 146(5): 732-45, 2011 Sep 02.

Artículo en Inglés | MEDLINE | ID: mdl-21884935

5.

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.

Menon, Indu; Sych, Taras; Son, Yeeun; Morizumi, Takefumi; Lee, Joon; Ernst, Oliver P; Khelashvili, George; Sezgin, Erdinc; Levitz, Joshua; Menon, Anant K.

J Biol Chem ; 300(2): 105649, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38237683

6.

Structural basis for KCTD-mediated rapid desensitization of GABA_B signalling.

Zheng, Sanduo; Abreu, Nohely; Levitz, Joshua; Kruse, Andrew C.

Nature ; 567(7746): 127-131, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30814734

7.

Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function.

Ellaithy, Amr; Gonzalez-Maeso, Javier; Logothetis, Diomedes A; Levitz, Joshua.

Trends Biochem Sci ; 45(12): 1049-1064, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-32861513

8.

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins.

Birke, Ramona; Ast, Julia; Roosen, Dorien A; Lee, Joon; Roßmann, Kilian; Huhn, Christiane; Mathes, Bettina; Lisurek, Michael; Bushiri, David; Sun, Han; Jones, Ben; Lehmann, Martin; Levitz, Joshua; Haucke, Volker; Hodson, David J; Broichhagen, Johannes.

Org Biomol Chem ; 20(30): 5967-5980, 2022 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-35188523

9.

Photoswitchable Serotonins for Optical Control of the 5-HT_2A Receptor.

Morstein, Johannes; Romano, Giovanna; Hetzler, Belinda E; Plante, Ambrose; Haake, Caleb; Levitz, Joshua; Trauner, Dirk.

Angew Chem Int Ed Engl ; 61(18): e202117094, 2022 04 25.

Artículo en Inglés | MEDLINE | ID: mdl-34989082

10.

Conformational dynamics of a class C G-protein-coupled receptor.

Vafabakhsh, Reza; Levitz, Joshua; Isacoff, Ehud Y.

Nature ; 524(7566): 497-501, 2015 Aug 27.

Artículo en Inglés | MEDLINE | ID: mdl-26258295

11.

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors.

Levitz, Joshua; Broichhagen, Johannes; Leippe, Philipp; Konrad, David; Trauner, Dirk; Isacoff, Ehud Y.

Proc Natl Acad Sci U S A ; 114(17): E3546-E3554, 2017 04 25.

Artículo en Inglés | MEDLINE | ID: mdl-28396447

12.

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.

Donthamsetti, Prashant C; Broichhagen, Johannes; Vyklicky, Vojtech; Stanley, Cherise; Fu, Zhu; Visel, Meike; Levitz, Joshua L; Javitch, Jonathan A; Trauner, Dirk; Isacoff, Ehud Y.

J Am Chem Soc ; 141(29): 11522-11530, 2019 07 24.

Artículo en Inglés | MEDLINE | ID: mdl-31291105

13.

Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.

Levitz, Joshua; Royal, Perrine; Comoglio, Yannick; Wdziekonski, Brigitte; Schaub, Sébastien; Clemens, Daniel M; Isacoff, Ehud Y; Sandoz, Guillaume.

Proc Natl Acad Sci U S A ; 113(15): 4194-9, 2016 Apr 12.

Artículo en Inglés | MEDLINE | ID: mdl-27035963

14.

Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics.

Carroll, Elizabeth C; Berlin, Shai; Levitz, Joshua; Kienzler, Michael A; Yuan, Zhe; Madsen, Dorte; Larsen, Delmar S; Isacoff, Ehud Y.

Proc Natl Acad Sci U S A ; 112(7): E776-85, 2015 Feb 17.

Artículo en Inglés | MEDLINE | ID: mdl-25653339

15.

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

Donthamsetti, Prashant C; Winter, Nils; Schönberger, Matthias; Levitz, Joshua; Stanley, Cherise; Javitch, Jonathan A; Isacoff, Ehud Y; Trauner, Dirk.

J Am Chem Soc ; 139(51): 18522-18535, 2017 12 27.

Artículo en Inglés | MEDLINE | ID: mdl-29166564

16.

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.

Comoglio, Yannick; Levitz, Joshua; Kienzler, Michael A; Lesage, Florian; Isacoff, Ehud Y; Sandoz, Guillaume.

Proc Natl Acad Sci U S A ; 111(37): 13547-52, 2014 Sep 16.

Artículo en Inglés | MEDLINE | ID: mdl-25197053

17.

Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP.

Luebbers, Alex; Gonzalez-Hernandez, Alberto J; Zhou, Myles; Eyles, Stephen J; Levitz, Joshua; Garcia-Marcos, Mikel.

Structure ; 32(1): 47-59.e7, 2024 01 04.

Artículo en Inglés | MEDLINE | ID: mdl-37989308

18.

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.

Menon, Indu; Sych, Taras; Son, Yeeun; Morizumi, Takefumi; Lee, Joon; Ernst, Oliver P; Khelashvili, George; Sezgin, Erdinc; Levitz, Joshua; Menon, Anant K.

bioRxiv ; 2024 Jan 05.

Artículo en Inglés | MEDLINE | ID: mdl-38045315

19.

Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.

Lao-Peregrin, Cristina; Xiang, Guoqing; Kim, Jihye; Srivastava, Ipsit; Fall, Alexandra B; Gerhard, Danielle M; Kohtala, Piia; Kim, Daegeon; Song, Minseok; Garcia-Marcos, Mikel; Levitz, Joshua; Lee, Francis S.

Cell Rep ; 43(1): 113595, 2024 01 23.

Artículo en Inglés | MEDLINE | ID: mdl-38117654

20.

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons.

Hergenreder, Emiliano; Minotti, Andrew P; Zorina, Yana; Oberst, Polina; Zhao, Zeping; Munguba, Hermany; Calder, Elizabeth L; Baggiolini, Arianna; Walsh, Ryan M; Liston, Conor; Levitz, Joshua; Garippa, Ralph; Chen, Shuibing; Ciceri, Gabriele; Studer, Lorenz.

Nat Biotechnol ; 2024 Jan 02.

Artículo en Inglés | MEDLINE | ID: mdl-38168993

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A ciliary synapse for "short-circuit" neuromodulation.

An epigenetic barrier sets the timing of human neuronal maturation.

Profiling the proximal proteome of the activated µ-opioid receptor.

A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.

Structural basis for KCTD-mediated rapid desensitization of GABA_B signalling.

Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function.

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins.

Photoswitchable Serotonins for Optical Control of the 5-HT_2A Receptor.

Conformational dynamics of a class C G-protein-coupled receptor.

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors.

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.

Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.

Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics.

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.

Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP.

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.

Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.

Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons.