The role of greater tuberosity healing in reverse shoulder arthroplasty: a finite element analysis.

BACKGROUND: The lack of greater tuberosity (GT) healing in proximal humerus fractures has been negatively correlated with outcomes for hemiarthroplasty; however, there is still debate regarding the effects of GT healing in reverse shoulder arthroplasty (RSA). Our goal was to examine the effects of GT healing using a kinematic finite element analysis (FEA) model. MATERIAL AND METHODS: Computer-aided design models of a medialized glenoid with a lateralized humerus (MGLH) RSA design were uploaded into an FEA shoulder model in 2 different configurations: healed greater tuberosity (HGT) and nonunion greater tuberosity (NGT). Deltoid muscle forces and joint reaction forces (JRFs) on the shoulder were calculated during abduction (ABD), forward flexion (FF), and external rotation (ER). RESULTS: Force magnitude of the anterior, middle, and posterior deltoid muscle as well as JRFs modeled in both GT scenarios were similar for ABD (muscle forces P = .91, P = .75, P = .71, respectively; and JRF P = .93) and for FF (muscle forces P = .89, P = .83, P = .99, respectively; and JRF P = .90). For ER, the force magnitude between 2 GT settings showed statistically significant differences (HGT: 9.51 N vs. NGT: 6.13 N) (P < .001). Likewise, during ER, JRFs were different, and the NGT group showed a steep drop in JRF after 10° of ER (HGT: 28.4 N vs. NGT: 18.38 N) (P < .001). CONCLUSION: GT healing does not seem to impact RSA biomechanics during abduction or forward flexion; however, it does affect biomechanics during external rotation. Overall orthopedic surgeons can expect good results for patients after RSA even with poor GT healing.

Effect of lateralized design on muscle and joint reaction forces for reverse shoulder arthroplasty.

BACKGROUND: Manufacturers of reverse shoulder arthroplasty (RSA) implants have recently designed innovative implants to optimize performance in rotator cuff-deficient shoulders. These advancements are not without tradeoffs and can have negative biomechanical effects. The objective of this study was to develop an integrated finite element analysis-kinematic model to compare the muscle forces and joint reaction forces (JRFs) of 3 different RSA designs. METHODS: A kinematic model of a normal shoulder joint was adapted from the Delft model and integrated with the well-validated OpenSim shoulder model. Static optimizations then allowed for calculation of the individual muscle forces, moment arms, and JRFs relative to net joint moments. Three-dimensional computer models of 3 RSA designs-humeral lateralized design (HLD), glenoid lateralized design, and Grammont design-were integrated, and parametric studies were performed. RESULTS: Overall, there were decreases in deltoid and rotator cuff muscle forces for all 3 RSA designs. These decreases were greatest in the middle deltoid of the HLD model for abduction and flexion and in the rotator cuff muscles under both internal rotation and external rotation. The JRFs in abduction and flexion decreased similarly for all RSA designs compared with the normal shoulder model, with the greatest decrease seen in the HLD model. CONCLUSIONS: These findings demonstrate that the design characteristics implicit in these modified RSA prostheses result in mechanical differences most prominently seen in the deltoid muscle and overall JRFs. Further research using this novel integrated model can help guide continued optimization of RSA design and clinical outcomes.

A computer simulation of short-term adaptations of cardiovascular hemodynamics in microgravity.

Astronauts in the microgravity environment experience significant changes in their cardiovascular hemodynamics. In this study, a system-level numerical model has been utilized to simulate the short-term adaptations of hemodynamic parameters due to the gravitational removal in space. The effect of lower body negative pressure (LBNP) as a countermeasure has also been simulated. The numerical model was built upon a lumped-parameter Windkessel model by incorporating gravity-induced hydrostatic pressure and transcapillary fluid exchange modules. The short-term (in the time scale of seconds and minutes) adaptations of the cardiac functions, blood pressure, and fluid volumes have been analyzed and compared with physiological data. The simulation results suggest microgravity induces a decrease in aortic pressure, heart rate, lower body capillary pressure and volume, and an increase in stroke volume, upper body capillary pressure and volume. The activation of LBNP causes an immediate increase in lower body blood volume and a gradual decrease in upper body blood volume. As a result, the fluid shift due to microgravity could be reversed by the LBNP application. LBNP also counters the impacts of microgravity on the cardiac functions, including heart rate and stroke volume. The simulation results have been validated using available physiological data obtained from spaceflight and parabolic flight experiments.

Modeling of high sodium intake effects on left ventricular hypertrophy.

Many clinical studies suggest that chronic high sodium intake contributes to the development of essential hypertension and left ventricular (LV) hypertrophy. In the present study, a system-level computer model has been developed to simulate the long-term effects of increased sodium intake on the LV mechanical functions and the body-fluid homeostasis. The new model couples a cardiovascular hemodynamics function model with an explicit account of the LV wall thickness variation and a long-term renal system model. The present model is validated with published results of clinical studies. The results suggest that, with increased sodium intake, the renal system function, the plasma hormone concentrations, and the blood pressure adapt to new levels of equilibrium. The LV work output and the relative wall thickness increase due to the increase of sodium intake. The results of the present model match well with the patient data.

Analytical modeling of capillary flow in tubes of nonuniform cross section.

The interface rise for the flow in a capillary with a nonuniform cross section distribution along a straight center axis is investigated analytically in this paper. Starting from the Navier-Stokes equations, we derive a model equation for the time-dependent rise of the capillary interface by using an approximated three-dimensional flow velocity profiles. The derived nonlinear, second-order differential equation can be solved numerically using the Runge-Kutta method. The nonuniformity effect is included in the inertial and viscous terms of the proposed model. The present model is validated by comparing the solutions for a circular cylindrical tube, rectangular cylindrical microchannels, and convergent-divergent and divergent-convergent capillaries. The validated model has been applied to capillaries with parabolic varying wall, sinusoidal wall, and divergent sinusoidal wall. The inertial and viscous effects on the dynamic capillary rise and the equilibrium height are investigated in detail.