Detalles de la búsqueda
1.
Targeting the Hedgehog pathway with novel Gli1 hydrophobic tagging degraders.
Bioorg Chem
; 138: 106649, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37307715
2.
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy.
Bioorg Med Chem
; 26(12): 3559-3572, 2018 07 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29805075
3.
GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space.
Bioorg Med Chem Lett
; 26(23): 5603-5612, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27825762
4.
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency.
Bioorg Med Chem Lett
; 26(12): 2900-2906, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27133482
5.
A novel proteolysis-resistant cyclic helix B peptide ameliorates kidney ischemia reperfusion injury.
Biochim Biophys Acta
; 1842(11): 2306-17, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25220479
6.
Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization.
Bioorg Med Chem Lett
; 25(3): 708-16, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25529740
7.
Metal-free TEMPO-promoted C(sp³)-H amination to afford multisubstituted benzimidazoles.
J Org Chem
; 79(10): 4727-34, 2014 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-24758603
8.
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.
Bioorg Med Chem
; 22(14): 3670-83, 2014 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24906513
9.
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.
Bioorg Med Chem
; 22(12): 3146-58, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24794743
10.
Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors.
Org Biomol Chem
; 11(9): 1545-62, 2013 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23188156
11.
Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.
Bioorg Med Chem
; 21(19): 5963-72, 2013 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23985689
12.
Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into ß-position to the carboxylic acid.
Eur J Med Chem
; 251: 115267, 2023 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36933395
13.
Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues.
Org Biomol Chem
; 10(6): 1239-45, 2012 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22179573
14.
Recent advances in the discovery of protein tyrosine phosphatase SHP2 inhibitors.
RSC Med Chem
; 13(3): 246-257, 2022 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35434626
15.
On-Demand Activation of a Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo.
J Med Chem
; 65(1): 333-342, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34963283
16.
Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis.
Chem Commun (Camb)
; 58(60): 8340-8343, 2022 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35758629
17.
Convergent synthesis of tetrahydropyranyl side chain of verucopeptin, an antitumor antibiotic active against multidrug-resistant cancers.
Chem Commun (Camb)
; 58(97): 13447-13450, 2022 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36350039
18.
Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.
Bioorg Med Chem
; 19(16): 4935-52, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21778063
19.
Discovery of novel (S)-alpha-phenyl-gamma-amino butanamide containing CCR5 antagonists via functionality inversion approach.
Bioorg Med Chem Lett
; 20(7): 2219-23, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20207141
20.
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J Am Chem Soc
; 130(50): 17075-84, 2008 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-19012396