1.
Bioorg Med Chem
; 16(21): 9432-42, 2008 Nov 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18835721
RESUMEN
Sixteen new thiazine-quinoline-quinones have been synthesised, plus one bicyclic analogue. These compounds inhibited neutrophil superoxide production in vitro with IC(50)s as low 60 nM. Compounds with high in vitro anti-inflammatory activity were also tested in a mouse model of acute inflammation. The most active compounds inhibited both neutrophil infiltration and superoxide production at doses 2.5 micromol/kg, highlighting their potential for development as novel NSAIDs.