Detalles de la búsqueda
1.
The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.
Med Res Rev
; 36(5): 924-63, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27192495
2.
Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.
J Comput Aided Mol Des
; 28(12): 1233-45, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25301376
3.
The accuracy of screening tools for sarcopenia in older Chinese adults: a systematic review and meta-analysis.
Front Public Health
; 12: 1310383, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38375338
4.
Effective screening strategy using ensembled pharmacophore models combined with cascade docking: application to p53-MDM2 interaction inhibitors.
J Chem Inf Model
; 53(10): 2715-29, 2013 Oct 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24050442
5.
Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response.
Cell Chem Biol
; 2023 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38157852
6.
A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions.
Redox Biol
; 34: 101565, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32422540
7.
Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.
Eur J Med Chem
; 207: 112734, 2020 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32866756
8.
Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown.
J Med Chem
; 63(9): 4644-4654, 2020 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32153174
9.
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy.
J Med Chem
; 62(8): 3840-3856, 2019 04 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-30444366
10.
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Redox Biol
; 26: 101266, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31279986
11.
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.
J Med Chem
; 62(14): 6796-6813, 2019 07 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31283229
12.
Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency.
Eur J Med Chem
; 143: 1578-1589, 2018 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29117896
13.
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.
Eur J Med Chem
; 146: 251-259, 2018 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29407955
14.
Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents.
Mini Rev Med Chem
; 18(4): 296-309, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-27484627
15.
Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions.
J Med Chem
; 59(24): 10837-10858, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27690435
16.
Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1.
J Med Chem
; 59(15): 7305-10, 2016 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27409246
17.
A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides.
Mol Biosyst
; 12(4): 1378-87, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26935067
18.
Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
ACS Med Chem Lett
; 7(9): 835-40, 2016 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27660687
19.
An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis.
Sci Rep
; 6: 26585, 2016 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27215610
20.
CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.
Sci Rep
; 6: 19004, 2016 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26743233