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1.

An inflammatory transcriptional switch.

Murtaugh, L Charles; MacDonald, Raymond J.

Nature ; 554(7693): 470-472, 2018 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-32094929

2.

An inflammatory transcriptional switch.

Murtaugh, L Charles; MacDonald, Raymond J.

Nature ; 554(7693): 470-472, 2018 02 22.

Artículo en Inglés | MEDLINE | ID: mdl-29469130

3.

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

Holmstrom, Sam R; Deering, Tye; Swift, Galvin H; Poelwijk, Frank J; Mangelsdorf, David J; Kliewer, Steven A; MacDonald, Raymond J.

Genes Dev ; 25(16): 1674-9, 2011 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-21852532

4.

Dominant and context-specific control of endodermal organ allocation by Ptf1a.

Willet, Spencer G; Hale, Michael A; Grapin-Botton, Anne; Magnuson, Mark A; MacDonald, Raymond J; Wright, Christopher V E.

Development ; 141(22): 4385-94, 2014 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-25371369

5.

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

Hale, Michael A; Swift, Galvin H; Hoang, Chinh Q; Deering, Tye G; Masui, Toshi; Lee, Youn-Kyoung; Xue, Jumin; MacDonald, Raymond J.

Development ; 141(16): 3123-33, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-25063451

6.

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.

Afelik, Solomon; Qu, Xiaoling; Hasrouni, Edy; Bukys, Michael A; Deering, Tye; Nieuwoudt, Stephan; Rogers, William; Macdonald, Raymond J; Jensen, Jan.

Development ; 139(10): 1744-53, 2012 May.

Artículo en Inglés | MEDLINE | ID: mdl-22461559

7.

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.

Ahnfelt-Rønne, Jonas; Jørgensen, Mette C; Klinck, Rasmus; Jensen, Jan N; Füchtbauer, Ernst-Martin; Deering, Tye; MacDonald, Raymond J; Wright, Chris V E; Madsen, Ole D; Serup, Palle.

Development ; 139(1): 33-45, 2012 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-22096075

8.

Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.

Direnzo, Daniel; Hess, David A; Damsz, Barbara; Hallett, Judy E; Marshall, Brett; Goswami, Chirayu; Liu, Yunlong; Deering, Tye; Macdonald, Raymond J; Konieczny, Stephen F.

Gastroenterology ; 143(2): 469-80, 2012 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-22510200

9.

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.

Kawaguchi, Yoshiya; Cooper, Bonnie; Gannon, Maureen; Ray, Michael; MacDonald, Raymond J; Wright, Christopher V E.

Nat Genet ; 32(1): 128-34, 2002 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-12185368

10.

Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation.

Azevedo-Pouly, Ana; Hale, Michael A; Swift, Galvin H; Hoang, Chinh Q; Deering, Tye G; Xue, Jumin; Wilkie, Thomas M; Murtaugh, L Charles; MacDonald, Raymond J.

PLoS One ; 18(10): e0291512, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-37796967

11.

Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.

Henke, R Michael; Savage, Trisha K; Meredith, David M; Glasgow, Stacey M; Hori, Kei; Dumas, Judy; MacDonald, Raymond J; Johnson, Jane E.

Development ; 136(17): 2945-54, 2009 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-19641016

12.

Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.

Masui, Toshihiko; Swift, Galvin H; Deering, Tye; Shen, Chengcheng; Coats, Ward S; Long, Qiaoming; Elsässer, Hans-Peter; Magnuson, Mark A; MacDonald, Raymond J.

Gastroenterology ; 139(1): 270-80, 2010 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-20398665

13.

Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex.

Meredith, David M; Masui, Toshihiko; Swift, Galvin H; MacDonald, Raymond J; Johnson, Jane E.

J Neurosci ; 29(36): 11139-48, 2009 Sep 09.

Artículo en Inglés | MEDLINE | ID: mdl-19741120

14.

Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics.

Layeghi-Ghalehsoukhteh, Somayeh; Pal Choudhuri, Shreoshi; Ocal, Ozhan; Zolghadri, Yalda; Pashkov, Victor; Niederstrasser, Hanspeter; Posner, Bruce A; Kantheti, Havish S; Azevedo-Pouly, Ana C; Huang, Huocong; Girard, Luc; MacDonald, Raymond J; Brekken, Rolf A; Wilkie, Thomas M.

Sci Rep ; 10(1): 20662, 2020 11 26.

Artículo en Inglés | MEDLINE | ID: mdl-33244070

15.

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

Smart, Nora G; Apelqvist, Asa A; Gu, Xueying; Harmon, Erin B; Topper, James N; MacDonald, Raymond J; Kim, Seung K.

PLoS Biol ; 4(2): e39, 2006 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-16435884

16.

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

Beres, Thomas M; Masui, Toshihiko; Swift, Galvin H; Shi, Ling; Henke, R Michael; MacDonald, Raymond J.

Mol Cell Biol ; 26(1): 117-30, 2006 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-16354684

17.

Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism.

Krah, Nathan M; Narayanan, Shuba M; Yugawa, Deanne E; Straley, Julie A; Wright, Christopher V E; MacDonald, Raymond J; Murtaugh, L Charles.

Dev Cell ; 50(6): 744-754.e4, 2019 09 23.

Artículo en Inglés | MEDLINE | ID: mdl-31422917

18.

Signaling and transcriptional control of pancreatic organogenesis.

Kim, Seung K; MacDonald, Raymond J.

Curr Opin Genet Dev ; 12(5): 540-7, 2002 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-12200159

19.

Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.

Holland, Andrew M; Góñez, L Jorge; Naselli, Gaetano; Macdonald, Raymond J; Harrison, Leonard C.

Diabetes ; 54(9): 2586-95, 2005 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-16123346

20.

A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs.

Kong, Y Megan; Macdonald, Raymond J; Wen, Xiaofei; Yang, Peng; Barbera, Victor M; Swift, Galvin H.

Gene Expr Patterns ; 6(7): 678-86, 2006 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-16487753

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An inflammatory transcriptional switch.

An inflammatory transcriptional switch.

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

Dominant and context-specific control of endodermal organ allocation by Ptf1a.

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.

Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.

Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation.

Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.

Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.

Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex.

Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics.

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism.

Signaling and transcriptional control of pancreatic organogenesis.

Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.

A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs.