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1.
Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.
Drug Metab Dispos
; 45(12): 1304-1316, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28912253
2.
Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.
Xenobiotica
; 47(8): 682-696, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27499331
3.
Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent.
Drug Metab Dispos
; 44(10): 1697-708, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27486238
4.
Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Drug Metab Dispos
; 44(5): 653-64, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26921386
5.
KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.
Drug Metab Dispos
; 44(5): 672-82, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26921387
6.
Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.
Xenobiotica
; 46(11): 986-1000, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26931777
7.
Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.
Drug Metab Dispos
; 37(3): 536-44, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19074975
8.
Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor.
Clin Pharmacokinet
; 44(12): 1247-66, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16372823
9.
An industry perspective on tiered approach to the investigation of metabolites in drug development.
Bioanalysis
; 6(5): 617-28, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24620804
10.
Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.
Eur J Pharm Sci
; 63: 103-12, 2014 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25008118
11.
Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species.
Curr Top Med Chem
; 11(4): 419-49, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21320068
12.
Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4ß-Hydroxycholesterol and Changes in Midazolam Exposure.
Clin Pharmacol Drug Dev
; 5(4): 245-9, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27138133
13.
Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.
Drug Metab Dispos
; 32(5): 566-71, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15100180
14.
N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.
Antimicrob Agents Chemother
; 46(9): 2752-64, 2002 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-12183225
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