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1.
Ultrasound Obstet Gynecol ; 62(1): 143-147, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-36508434

RESUMEN

OBJECTIVE: To determine the relationship between the clinical outcome of suburethral sling surgery for stress urinary incontinence and sling location on ultrasound examination. METHODS: This was a retrospective study of patients diagnosed with stress urinary incontinence who were treated with a suburethral sling by a single surgeon between January 2009 and October 2016. Four-dimensional volumes acquired on transperineal ultrasound at least 3 months postoperatively were analyzed and the gap between the sling and symphysis pubis (sling-pubis gap (SPG)) on Valsalva maneuver was measured. Continence was assessed on a cough stress test at follow-up. RESULTS: A total of 378 patients were included, with a mean follow-up of 14.3 months. The success rate of sling surgery was 89.4%. The mean ± SD SPG on Valsalva maneuver was 12.0 ± 2.5 mm in women who were clinically continent at follow-up and 14.1 ± 2.8 mm in those with failed surgery (P < 0.001). CONCLUSION: A shorter SPG on transperineal ultrasound imaging after suburethral sling surgery is associated with cure of stress urinary incontinence. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.


Asunto(s)
Cabestrillo Suburetral , Incontinencia Urinaria de Esfuerzo , Humanos , Femenino , Incontinencia Urinaria de Esfuerzo/diagnóstico por imagen , Incontinencia Urinaria de Esfuerzo/cirugía , Estudios Retrospectivos , Resultado del Tratamiento , Ultrasonografía
2.
Ceska Gynekol ; 84(2): 115-120, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31238681

RESUMEN

OBJECTIVE: Is it possible to estimate urethral mobility based on MUCP measurements? DESIGN: Retrospective study. SETTING: Department of Gynecology and Obstetrics, 1st Medical Faculty, Charles University, General Teaching Hospital, Prague. METHODS: This retrospective study included 567 patients from three prospective studies within years 2002 to 2009. Ultrasound examination was performed in 560 of them and maximal urethral closure pressure (MUCP) values were measured in 507 women. The MUCP was defined as the difference between maximum urethral pressure and bladder pressure. An ultrasound examination was performed using the transperineal approach in accordance with the recommendations of the German Urogynecology Working Group and ICS, IUGA terminology. The mobility was expressed as a distance between the position at rest and at the maximal Valsalva manoeuvre. Data were summarized as mean and median, with SD and quantile range for measures of variability. Either a matched pairs t-test or Wilcoxon test was used for statistical evaluation. RESULTS: Mean MUCP was 47.4 cm H2O (SD 22.2, first quantile 32, third quantile 62). Mean urethral descent was 20.6 mm (SD 8.2, first quantile 14.9, third quantile 25.6 mm). Using regression analysis there was an increase in urethral descent; this difference is statistically significant. For a MUCP increase of 10 cm H2O we could estimate an increase in urethral descent of 1.1 mm. CONCLUSION: We established a statistically significant relationship between urethral descent and MUCP. Unfortunately those differences are not clinically relevant, especially for MUCP over 20 cm H2O. For MUCP below 20 cm H2O low urethral descent is more likely. Clinical use of MUCP as predictor of urethral descent is limited due to the high variability involved.


Asunto(s)
Uretra/fisiopatología , Incontinencia Urinaria de Esfuerzo/cirugía , Urodinámica/fisiología , Femenino , Humanos , Embarazo , Estudios Prospectivos , Estudios Retrospectivos , Resultado del Tratamiento , Vejiga Urinaria/fisiopatología , Incontinencia Urinaria de Esfuerzo/diagnóstico , Procedimientos Quirúrgicos Urológicos/efectos adversos
3.
Ceska Gynekol ; 84(2): 111-114, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31238680

RESUMEN

OBJECTIVE: To compare diagnostic possibilities of endoanal (EAUS) and transperineal (TPUS) ultrasound during anal sphincter examination and patients preferences. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynaecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague. METHODS: Patients involved had EAUS and TPUS of anal sphincter. First group were patients scheduled for control check after vaginal delivery complicated with anal sphincter injury (post OASI) and adequate suture. Second (control) group contained new patients coming for urogynecological examination with some symptoms of anal incontinence. Refusal were noted and after completing both ultrasounds patients marked on visual analog scale (VAS) the level of dyscomfort and answered few simple questions about their preference of exam in future. RESULTS: This study contains twenty-nine patients (fifteen post OASI and fourteen in control group). Two patients (post OASI) refused EAUS and one patient from control group did not mark the level of dyscomfort. In post OASI group eleven patients (84.6%) considered EAUS as botherless or slighly bothering (VAS 3). The average dyscomfort for EAUS was 1.92 and for TPUS 1.08. Five patients marked EAUS more dyscomfortable as TPUS and this difference is significant (p < 0.05). In control group eleven patients (84.6%) marked EAUS as botherless or slightly bothering (VAS 3). There was no difference between post OASI and control group. We have not found by any exam residual anal sphincter defect in any patient post OASI. For this reason we could not decide about efectivity. In matter of future preference patients would prefer TPUS to EAUS in case of similar effectivity. However, in case of different effectivity patients would prefer the more effective. CONCLUSION: Our patients prefer less dyscomfortable TPUS. The pilot study did not display higher effectivity of EAUS in diagnostics of residual anal sphincter defect.


Asunto(s)
Canal Anal/diagnóstico por imagen , Canal Anal/lesiones , Incontinencia Fecal/diagnóstico por imagen , Incontinencia Fecal/etiología , Ultrasonografía/métodos , Adulto , Parto Obstétrico/efectos adversos , Femenino , Humanos , Proyectos Piloto , Embarazo , Estudios Prospectivos
4.
Ceska Gynekol ; 83(3): 188-194, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30764618

RESUMEN

OBJECTIVE: Detect urethrovesical junction descent and mobility values in women with stress incontinence prior to surgical treatment. DESIGN: Retrospective study. SETTINGS: Department of Gynecology and Obstetrics, First Medical Faculty, Charles University, General Teaching Hospital, Prague. METHODS: A retrospective study included 568 patients from three different prospective studies. We have ultrasound data in 560 of them. All of these patients underwent surgical treatment of stress incontinence. During the preoperative examination, patients were subjected to clinical, urodynamic and ultrasound examinations, in which we focused on the urethrovesical junction descent and mobility rate in the maximal Valsavs maneuver. Statistical evaluation of the data was performed by a pair t-test or Wilcoxon test. RESULTS: The mean dorsocaudal descent of the urethrovesical junction was 20.6 mm (SD 8.2, first quantile 14.9, third quantile 25.6 mm). We did not find any statistically significant differences in the acquired parameters at different time periods. CONCLUSION: Due to the high variability of urethrovesical junction descent and mobility, ultrasound examination should be part of all urogynecological preoperative examinations to provide the operator with information on urethrovesical junction descent and mobility prior to surgery and then compare it with postoperative results.


Asunto(s)
Ultrasonografía/métodos , Uretra/fisiopatología , Incontinencia Urinaria de Esfuerzo/diagnóstico por imagen , Adulto , Anciano , Femenino , Humanos , Embarazo , Estudios Prospectivos , Estudios Retrospectivos , Vejiga Urinaria/diagnóstico por imagen , Incontinencia Urinaria de Esfuerzo/cirugía , Urodinámica
5.
Ceska Gynekol ; 83(4): 257-262, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30441955

RESUMEN

OBJECTIVE: The knowledge of the mobility of urethra plays important role in patients with stress urinary incontinence and its assessment is a part of standard urogynecological examination. It has been assumed that increased mobility is associated with higher likelihood of successful treatment. There is arbitrary defined cut-off for hypermobile urethra - descend of more than 15 mm or 30-degree resp. 50-degree rotation or more during Valsalva manoeuvre. Clinically we routinely categorize mobility of the urethra as high mobile or hypermobile urethras, low mobile urethra and the situation in-between as mobile urethras. But how accurate are we with such a subjective assessment? We have provided retrospective analysis of mobility of the urethra assessed during the clinical examination by transperineal ultrasound (US) with subjective scoring of the mobility (low, norm, hyper) and compared this assessment with detailed measurement of descent and rotation of the urethra. DESIGN: Retrospective cohort study. SETTING: Ob/Gyn department First Faculty of Medicine, Charles University and General University Hospital, Prague. METHODS: This is a retrospective analysis of urethral mobility of women diagnosed with urodynamic stress incontinence (USI) and treated with tension free vaginal slings during the period 01/2009 - 10/2016. For each patient, there was available description of mobility at the time of preoperative assessment (low-, norm- or hyper-mobile) and we compared this assessment with measured parameters of bladder neck mobility analysed later from stored 4D US volumes. We have measured dorsocaudal movement of the bladder neck (BN) (H-distance). This is the distance of the BN from the horizontal line at the level of lower margin of the symphysis and we compared the position at rest and at Valsalva. Secondly, we measured rotation of the urethra using the gama angle - angle between the line connecting BN to lower margin of symphysis and axis of symphysis at rest and during the Valsalva manoeuvre. Mobility of the BN is the difference between the rest and Valsalva position. We compared the objective parameters of mobility with subjective assessment. We have provided correlation of both objective parameters. RESULTS: 427 patients were treated during the analysed period, 393 had available stored 4D US volume for analysis. Mean age 56.5 years (min 29, max 87, SD 7.9), mean BMI 27.4 (min 18.3, max 39.6, SD 7.9), mean parity 2.14. Mean descent of the bladder neck was 11.8 mm (min -1, max 37; SD 6.9) Mean rotation of the bladder neck was 38.8 degree (min -5, max 118, SD 20.0). When we subjectively assessed the mobility as low the mean mobility was 23.9 ° resp. 7.3 mm, for normal 34.8 ° resp. 10.4 mm and 48.6 ° resp. 15 mm for hypermobile uretras. We have found good correlation of both parameters - H-distance, gama angle - r = 0.693. CONCLUSION: Subjective assessment of mobility of the urethra seems to be reasonably accurate for distinguishing between low and hypermobile uretra.


Asunto(s)
Uretra/fisiopatología , Urodinámica/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Cohortes , Femenino , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Vejiga Urinaria/fisiopatología , Incontinencia Urinaria de Esfuerzo/fisiopatología , Incontinencia Urinaria de Esfuerzo/cirugía , Maniobra de Valsalva
6.
Ceska Gynekol ; 83(3): 164-168, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30764614

RESUMEN

OBJECTIVE: Many clinical studies indicate that pharmacologic treatment of overactive bladder (OAB) is considered effective and safe, but in real clinical practice a substantial proportion of patients discontinues the treatment. The reason for discontinuing the treatment most frequently reported is lack of efficacy and/or side effects. A further significant proportion of patients reports that they stopped the treatment because the symptoms disappeared or were resolved. This β3 agonist seems to be crucial in providing comparable efficacy in the OAB treatment and better tolerance in comparison with anticholinergics. Our aim was to investigate the durability of the mirabegron effect in successfully treated OAB patients and to understand more fully what prompts patients to return to the medication. Is this merely a subjective decision, or is it based on objective worsening of the symptoms? DESIGN: Analysis of multicentre prospective study. SETTINGS: Gynaecology and Obstetric Department First Faculty of Medicine, Charles University and General University Hospital, Prague. METHODS: This is an analysis of longitudinal multicentre study of OAB mirabegron treatment persistence. After continuing mirabegron treatment for more than 18 months patients were assessed by bladder diary and specific questionnaires. Patients with a UB-VAS score (Urgency Bother Visual Analogue Scale) of 50 or less were asked to stop the mirabegron treatment and restart the treatment any time later if they felt the need. Patients recorded the date of return to medication; they kept a daily bladder diary and filled in the same questionnaires as at the time of medication discontinuation. We provide a comparison of symptoms at the time of mirabegron discontinuation and at the time of mirabegron medication restart. RESULTS: 206 patients entered the study. 176 females (85%) and 30 males (15%) with mean age 62.9 ± 12.43, BMI ranging from 16.6 to 48.0 (mean 27.2 ± 4.96). After 18 months 126 patients were persisting with mirabegron treatment. 89 patients had UB-VAS score 50 (89 of 126 patients, i.e. 71%). Those patients were asked to stop the treatment. From the eligible group of 89 patients, 19 patients (21%) were unwilling to stop the treatment and were therefore excluded. There were no significant differences in bladder diary and QoL characteristics between patients who were unwilling to discontinue the treatment and patients who did stop taking the medication. The group who stopping treatment comprised 70 patients. At the time of last follow-up 22 patients (31%) had not restarted the medication, with mean follow-up of 122.6 days. Therapy was restarted by 48 patients (i.e. 69% of 70). The mean time without treatment was 48 days (± 32.0 days), median 53 days. There was significant worsening of OAB symptoms and subjective bother at the time of restarting the medication. CONCLUSION: Subjective bother based on increase number of frequency, urgency, and nycturia causes patients with positive experience to return to mirabegron treatment. Most patients with successfully-treated symptoms of OAB who discontinue treatment can only do so temporarily. A worsening of the symptoms occurs rather rapidly, because 69% of patients with OAB symptoms successfully treated with mirabegron (UB-VAS 50) are unable to discontinue taking the medication for more than two months.


Asunto(s)
Acetanilidas/uso terapéutico , Tiazoles/uso terapéutico , Vejiga Urinaria Hiperactiva/tratamiento farmacológico , Agentes Urológicos/uso terapéutico , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Resultado del Tratamiento
7.
Ceska Gynekol ; 82(1): 59-64, 2017.
Artículo en Checo | MEDLINE | ID: mdl-28252312

RESUMEN

OBJECTIVE: The review article describes the possibilities of procedures for failed anti-incontinence surgery - sling procedure or "bulking agent"? DESIGN: Review article. SETTING: Department of Obstetrics and Gynecology, General Faculty Hospital and 1st Medical Faculty, Charles University, Prague. MATERIALS AND METHODS: The correct choice of procedure type to treat persistent SUI (Stress Urinary Incontinence) which persists or soon reoccurs after anti-incontinence surgery is often problematic. The procedures that treat SUI decrease excessive mobility of the urethra by partially compressing it. If the excessive mobility of the urethra and BN (bladder neck) persist and MUCP (Maximal Urethral Closure Pressure) is within normal range, then we choose a new sling operation to treat the persistent SUI. What type of sling procedure is preferable in this situatitons: transobturator, retropubic or possibly SISs (Single Incision Slings)? SISs are not adequately fixed to the surrounding structures after implantation and are often not of the correct size - especially regarding length - with poor compliance (elasticity). For mentioned reasons we do not use them in reoperations. In this cases we choose such a sling which is properly fixed to the surrounding structures, is of sufficient length, and of appropriate elasticity. When choosing the right type of procedure we also have to consider previous operations: for example, whether reconstructive surgery of pelvic floor defects using mesh has been carried out, where the mesh has been placed, and whether it might be an obstacle to the newly implanted sling. If there is a low urethral mobility after the unsuccessful incontinence operation and a low MUCP is observed on urodynamic examination, then we prefer either a retropubic sling or the application of a bulking agent. The decision of which method to choose also depends on other circumstances, such as whether the patient has undergone radiation treatment or more than on previous surgery to treat SUI. The results of urodynamic, ultrasound and other examinations are very important. CONCLUSIONS: The choice of the right type of surgery to treat SUI after a previous failed procedure depends on information and findings from complex examination of the patient. Case history, examination results, imaging and the experience of the surgeon in individual procedures are therefore most important.


Asunto(s)
Resinas Acrílicas/uso terapéutico , Materiales Biocompatibles/uso terapéutico , Hidrogeles/uso terapéutico , Diafragma Pélvico/cirugía , Cabestrillo Suburetral , Mallas Quirúrgicas , Uretra/cirugía , Incontinencia Urinaria de Esfuerzo/cirugía , Femenino , Humanos , Recurrencia , Reoperación , Insuficiencia del Tratamiento , Ultrasonografía , Vejiga Urinaria , Incontinencia Urinaria de Esfuerzo/diagnóstico por imagen , Urodinámica , Procedimientos Quirúrgicos Urológicos/métodos
8.
Ceska Gynekol ; 82(6): 424-429, 2017.
Artículo en Checo | MEDLINE | ID: mdl-29302974

RESUMEN

OBJECTIVE: The objective of this study was to monitor and evaluate the persistence and cure effect of Mirabegron in patients with overactive bladder syndrome after 18 months of treatment. DESIGN: Prospective clinical study. SETTINGS: 10 gynecological and urological departments in CZE. MATERIALS AND METHODS: This is an analysis of a prospective, multicenter monitoring study from May to September 2014. The patients were 18 years old and had symptoms of OAB for a minimum of three months. Patient check-ups were performed 18 months after the first visit. The dosage of Mirabegron was 50 mg per day in 162 patients, though for 44 of the patients the treatment was changed. During the final check-ups it was ascertained how many patients had discontinued treatment with Mirabegron, at first as a proportion of the whole group of patients and then in relation to gender, age, previous treatment with anticholinergic drugs and changes in the treatment during the study. To evaluate treatment efficacy we employed the TS-VAS and PPBC. During the check-up it was ascertained how many patients had discontinued treatment with Mirabegron, and reasons for this were established. The statistics were calculated using the softwares STATISTICA 12 (Statsoft, USA) and SPSS 20.0 (IBM, v.20.0). RESULTS: Prospective monitoring was performed on 206 patients. Their mean age was 62.8 years; mean body mass index for the whole group of patients was 27.3. At the check-up 18 months post-initiation of treatment it emerged that 79 (38.3%) patients had discontinued the treatment. The reasons for discontinuation of treatment were insufficient treatment efficacy (35.4% of patients), while 49.4% cited other reasons (hospitalisation, surgery, gravidity) and 15.2% of patients discontinued therapy because of side effects. The evaluation of treatment persistence with Mirabegron in groups with relation to gender, age and previous treatment with anticholinergic drugs did not establish statistically significant differences. However, there was a statistically significant difference between groups in relation to changes of treatment during study. At the evaluation of the efficacy of the treatment during the check-up 18 months after initiation of treatment the mean TS-VAS was 73.4, a decrease of the scale of bothers evaluated by PPBC before treatment from a mean value of 4.6 to a value of 2.7. CONCLUSIONS: In our clinical study 18 months treatment persistence with Mirabegron was 61.7%. The reasons were reduced side effects and good cure effect of the drug.


Asunto(s)
Acetanilidas/uso terapéutico , Tiazoles/uso terapéutico , Vejiga Urinaria Hiperactiva/tratamiento farmacológico , Agentes Urológicos/uso terapéutico , Adolescente , Humanos , Persona de Mediana Edad , Estudios Prospectivos , Resultado del Tratamiento
9.
Ceska Gynekol ; 82(1): 48-52, 2017.
Artículo en Checo | MEDLINE | ID: mdl-28252310

RESUMEN

OBJECTIVE: Overactive bladder syndrome is chronic disease with high prevalence rate (9-42%). This syndrome requires long term therapy, but the treatment persistence is after 3 months over all 26% with further decline in one-year period as low as 18.5%. Main reasons for stopping the treatment are low efficacy, the medication didnt work as expected and side effects. How much satisfied are patients with mirabegron persisting on its treatment? To answer this question, we provided secondary analysis of multicentre follow-up study of patients on mirabegron. We compared subjective and objective parameters between patients continuing mirabegron treatment and those who discontinued the medication. DESIGN: Secondary analysis multicentre prospective follow-up. SETTINGS: Ob/Gyn department First Faculty of Medicine, Charles University and General University Hospital, Prague. METHODS: It is secondary analysis of multicentre prospective study following patients with mirabegron 50 mg treatment. We have analysed objective data from micturition diary and subjective data using visual analogue scales (UB-VAS - urgency bother visual analogue scale, and TS-VAS - treatment satisfaction visual analogue scale) and compared data between the group of patients continuing mirabegron treatment and patients who stopped the medication during the study. RESULTS: We included 206 patients (176 women, 30 men) with diagnosis of overactive bladder. Patients continuing the treatment (group n1) had baseline UB-VAS 70.1 vs. 75.0 (p = n.s.) in patients who stopped the medication during the follow-up period (group n2). Baseline episodes of severe urgency and urge incontinence where n1 - 5.1 vs. n2 - 6.2 (p = n.s.). Six months urgency bother score UB-VAS was n1 - 32.4 vs. n2 - 58.9 (p < 0,001). Treatment satisfaction TS-VAS was n1 - 80.3 vs. n2 - 57.7 (p < 0,001). Number of severe urgencies with or without urge incontinence was after 6 months n1 - 2.1 vs. n2 - 3.3 (p = n.s.), lower in group continuing the treatment. When comparing the data between patients stopping the medication for reason of low efficacy (group s1) with patients stopping for other reasons (group s2) UB-VAS bas: s1 - 68.5 vs. s2 - 43.9 (p = 0.001); TS VAS s1 - 45.1 vs. s2 - 58.4 (p = n.s.) and number of severe urgency with or without incontinence s1 - 5.9 vs. s2 - 3.2 (p = 0.009). CONCLUSION: Our data shows that patients expectation on treatment with mirabegron is not low. Patients accept treatment either without side effects or with decrease of severe urgency with or without urge incontinence around 50%. Regardless the reason the patients continuing the treatment scale treatment satisfaction - TS-VAS over 70 points.


Asunto(s)
Acetanilidas/uso terapéutico , Agonistas de Receptores Adrenérgicos beta 3/uso terapéutico , Satisfacción del Paciente , Tiazoles/uso terapéutico , Vejiga Urinaria Hiperactiva/tratamiento farmacológico , Incontinencia Urinaria de Urgencia/tratamiento farmacológico , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Hospitales Universitarios , Humanos , Persona de Mediana Edad , Estudios Prospectivos , Resultado del Tratamiento , Vejiga Urinaria Hiperactiva/complicaciones , Incontinencia Urinaria de Urgencia/etiología , Adulto Joven
10.
Ceska Gynekol ; 81(5): 324-335, 2016.
Artículo en Checo | MEDLINE | ID: mdl-27897018

RESUMEN

OBJECTIVE: The aim of this study was to compare fixation and mobility of adjustable single-incision (Ajust) and standard transobturator midurethral sling (TVT-O) tapes based on postoperative ultrasound monitoring of the position of the tape at rest and at maximal Valsava (tape descent). The hypothesis was that fixation of SIMS Ajust is comparable to that achieved by the standard transobturator midurethral sling. SETTING: Gynecology and Obstetrics Department, GUH and 1st Charles University Prague; Gynecology and Obstetrics Department Masarykova nemocnice Ústí nad Labem. DESIGN: Randomized trial, secondary analysis of ultrasound follow-up. METHODS: Between May 2010 and May 2012 100 women with proven urodynamic stress urinary incontinence were included in this randomized trial.All patients underwent a complete urogynecological investigation before the procedure (clinical examination, urodynamics, ultrasound examination), and they filled in the ICIQ and iQol questionnaires; after surgery, to evaluate their satisfaction with the procedure, VAS and Likert scales were added.Ultrasound examination as part of each post-operative check-up was performed the first day after surgery, two weeks, three months and one year after surgery. Ultrasound measurements were taken in a supine position at rest and during maximal Valsalva. Position of the bladder neck was assessed, and the position of the tape with respect to upper and lower tape margins. RESULTS: At one-year follow up no differences in subjective cure rates and objective cure rates were observed. In all checks after surgery there was no difference between the position of the tape at rest and at maximal Valsalva between the Ajust and TVT-O groups.The length of the upper and lower tape descent was similar. In TVT-O patients the mean length of upper tape margin descent increased from 8.8 mm on the first day after surgery to 10.0 mm three months after surgery; afterwards it remained stable. For Ajust patients there was virtually the same development - from 9.1 to 12 mm - and there was no further increase in the tape descent following the three-month measurement. CONCLUSIONS: The quality of the tape fixation after the Ajust procedure is as good as after standard transobturator midurethral sling. We did not observe any statistically significant differences in tape position and descent, indicating that the function is similar to obturator tape, which in turn suggests the same clinical efficacy. Ultrasound monitoring should be the part of post-operative monitoring whenever novel surgical techniques are introduced.


Asunto(s)
Procedimientos Quirúrgicos Ginecológicos , Cabestrillo Suburetral , Vejiga Urinaria/diagnóstico por imagen , Incontinencia Urinaria de Esfuerzo/cirugía , Adulto , Anciano , Femenino , Humanos , Persona de Mediana Edad , Ultrasonografía
11.
Ceska Gynekol ; 80(4): 244-8, 2015 Aug.
Artículo en Checo | MEDLINE | ID: mdl-26265411

RESUMEN

OBJECTIVE: The objective of this monitoring was to evaluate persistence in the treatment of patients with overactive bladder syndrome (OAB) using mirabegron. DESIGN: Prospective clinical study. SETTING: 10 gynecological and urological departments in CZE. MATERIALS AND METHODS: This is an analysis of a prospective, multicenter monitoring which started in May 2014 and will continue for 1 year. This monitoring included patients 18 years old who have had symptoms of OAB for minimum 3 months. The patient check-up was performed 6 months (±2 weeks) after the first visit. The dosage of mirabegron was 50 mg per day. For the evaluation the treatment efficacy we employed the TS-VAS and PPBC. During the check-up it was ascertained how many patients discontinued the treatment with mirabegron, and reasons for this interruption were established. The statistics were calculated using the software SPSS 20.0. RESULTS: A prospective monitoring was performed on 206 patients. Their mean age was 62.8 years (range 23-89); mean body mass index for the whole group of patients was 27.3. At the check-up 6 months post-initiation of treatment it emerged that 55/206 (27%) patiens had discontinued the treatment. The reasons for discontinuation of treatment were: 24/55 (43%) insufficient treatment efficacy, 29/55 (53%) other reasons (the main reasons here were hospitalisation, surgery, gravidity) and 2/55 discontinued therapy because of side effects. The side effects were tachycardia, eye irritation, lower abdominal pain and vasculitis, and they were mild in nature. The termination of the study was 7/28 (25%) in the group of patients without previous treatment before mirabegron. Discontinuation of the treatment in the group of patients with previous anticholinergic treatment was 48/178 (27%). At the evaluation of the efficacy of the treatment during the check-up 6 months after initiation of treatment the mean TS-VAS was 77.5, a decrease of the scale of bothers evaluated by PPBC before treatment from a mean value of 3.56 to a value of 1.77. CONCLUSIONS: Our hypothesis, that persistence in treat-ment with mirabegron would be relatively high due to reduced side effects and better cure effect, was confirmed, and this is the reason for higher rates of persistence in the treatment at 6 months check-up (73%).


Asunto(s)
Acetanilidas/uso terapéutico , Agonistas de Receptores Adrenérgicos beta 3/uso terapéutico , Tiazoles/uso terapéutico , Vejiga Urinaria Hiperactiva/tratamiento farmacológico , Acetanilidas/efectos adversos , Adulto , Anciano , Anciano de 80 o más Años , Índice de Masa Corporal , Antagonistas Colinérgicos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Cooperación del Paciente , Estudios Prospectivos , Tiazoles/efectos adversos , Resultado del Tratamiento , Vejiga Urinaria Hiperactiva/diagnóstico
12.
Ceska Gynekol ; 80(5): 351-4, 2015 Oct.
Artículo en Checo | MEDLINE | ID: mdl-26606120

RESUMEN

OBJECTIVE: We had provided secondary analysis of our randomized controlled study comparing vaginal mesh with sacrospinous fixation for vaginal prolapse. We correlated data from subjective and objective assessment. Secondly we had provided correlations results of subjective and objective assessment between patient with anatomical failure and those without. The aim of this analysis was to provide correlation between objective and subjective outcome measures. DESIGN: Subanalysis of randomized controlled study. SETTING: Obstetric Gynecology Department, First Faculty of Medicine of Charles University and General University Hospital in Prague. METHODS: This is secondary analysis of single center randomized controlled study comparing two standard procedures for vaginal prolapse after hysterectomy in patients with levator avulsion injury. We had analyzed pre- and postoperative subjective POPDI score (Pelvic Organ Prolapse Distress Inventory) and correlated this score with most prolapsed portion of vaginal wall. We had compared all vaginal compartments using POPQ (Pelvic Organ Prolapse Quantification): anterior wall with point Ba, apical with point C, and posterior with point Bp. Subsequently we compared subjective POPDI score in group of patients with anatomical failure and those without. RESULTS: We had included in randomized study 70 women. Mean preoperative POPDI score was 65.25 (3.57-200). We didnt found any correlation between subjective score and objective assessment in preoperative data: POPDI vs. Ba (p = 0.75) POPDI vs. C (p = 0.57) a POPDI vs. Bp (p = 0.22) and no correlation in postoperative assessment. Postoperative POPDI score decreased to 26.1, but there was no difference in POPDI score in woman with anatomical failure and no failure - 17.4 vs. 23.3 (p = 0.64)CONCLUSION: Secondary analysis of randomized controlled study had shown that objective and subjective assessment have poor correlation. We didnt found any correlation between degree of prolapse and intensity of complains. The large inter-individual variability in symptoms and low sensitivity of subjective assessment to detect difference makes subjective assessment as an inappropriate tool as a primary outcome measure of pelvic floor surgery.


Asunto(s)
Ligamentos/cirugía , Diafragma Pélvico/lesiones , Mallas Quirúrgicas , Prolapso Uterino/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Histerectomía/efectos adversos , Persona de Mediana Edad , Evaluación de Resultado en la Atención de Salud , Sensibilidad y Especificidad , Evaluación de Síntomas , Prolapso Uterino/etiología
13.
Ceska Gynekol ; 80(3): 196-203, 2015 Jun.
Artículo en Checo | MEDLINE | ID: mdl-26087214

RESUMEN

OBJECTIVE: The aim of this study is to compare quality of life in 3-month follow-up after the use of transobturator tape TVT-O and single incision tape AJUST in the treatment of urodynamic stress urinary incontinence (USI). DESIGN: Randomized trial. SETTING: Gynekologicko-porodnická klinika LF UK a FN Plzen, Gynekologicko-porodnická klinika 1. LF UK a VFN Praha. MATERIALS AND METHODS: Between May 2010 and May 2012 100 women with proven urodynamic stress urinary incontinence were included in this randomized trial. These patients were randomly chosen and devided into two group: 50 patients for TVT-O procedure and 50 patients for AJUST procedure. All of the patients underwent a complete urogynecological examination prior to the actual procedure (clinical examination, urodynamic examination, ultrasound examination) and filled in ICIQ-SF and iQol questionnaires. After the surgery, the patients satisfaction was evaluated by visual analoque scale (VAS) and Likert scale and by ICIQ-SF and iQol questionnaires. The intensity and length of postoperative pain was monitored using the visual analogue scale. The patients underwent an examination after 3 months. RESULTS: In both groups of participants no significant differences regarding age, BMI, parity, history of surgery for gynecological disorders, were found. Preoperative urodynamic, ICIQ-SF and iQol parameters were also not significantly different. In the 3-month follow-up 48 participants from TVT-O group and 50 participants from the AJUST group were monitored. No statistically significant differences in subjective and objective parameters were found. Subjectively stress incontinence was not present in 97.9% in the TVT-O and 96.0% in the group AJUST. Objectively stress test was negative in 93.8% in the TVT-O and 94% in group AJUST. By evaluating the ICIQ and iQol were found no statistical differences in the quality of life in both operating groups. CONCLUSION: At 3-months follow up we did not find any statistical difference between subjective and objective outcome for single incision tape AJUST and TVT-O. In the AJUST group lower intensity and shorter duration of postoperative pain were observed.


Asunto(s)
Satisfacción del Paciente , Calidad de Vida , Incontinencia Urinaria de Esfuerzo/cirugía , Adulto , Anciano , Femenino , Humanos , Persona de Mediana Edad , Cabestrillo Suburetral/efectos adversos , Encuestas y Cuestionarios , Resultado del Tratamiento , Incontinencia Urinaria de Esfuerzo/psicología , Urodinámica
14.
Ceska Gynekol ; 80(1): 25-9, 2015 Jan.
Artículo en Checo | MEDLINE | ID: mdl-25723075

RESUMEN

OBJECTIVE: The objective of this study was to evaluate the cure effect of a transurethral injection of Bulkamid® for recurrent female stress and mixed urinary incontinence in women who had undergone failed tape surgery. Our hypothesis was that cure effect of Bulkamid® is positive in patients when previous tape anti-incontinence surgery has been unsuccessful. DESIGN: Retrospective clinical study. SETTINGS: Department of Obstetrics and Gynecology, 1st Medical Faculty, Charles University and General Faculty Hospital in Prague. MATERIALS AND METHODS: This retrospective study featured 34 patients with recurrent urinary incontinence (SUI: 28, mixed: 6 - predominant symptom was SUI) after unsuccessful tape anti-incontinence surgery. 25 of the patients had undergone anti-incontinence surgery more than once. The cure effect of a transurethral injection of Bulkamid® was evaluated an average of 29 months after the surgery; the minimum period after surgery was 6 months. Subjective assessment of the leakage of urine was based on the International Consultation on Incontinence Questionnaire - Short form (ICIQ-UI SF) filled in before and after surgery. An improvement in urinary incontinence was defined as a drop in the score of more than 50%. Objective assessment of leakage of urine was assessed by cough test. The cure effect was evaluated by VAS (Visual Analogue Scale) score and by using the five-point Likert score. Ethical committee approval was obtained, and all subjects gave written informed consent to participate in the study. RESULTS: The mean age of patients was 71.03 years, mean body mass index (BMI) 29.12 and mean parity 1.91. The cough test showed that 4/34 (11.8%) of patients had negative results for this test after the operation. The ICIQ-UI SF questionnaire showed that 14/34 (41.2%) of our patients were dry or improved after surgery. The mean VAS score was 62.4 after the operation. The Likert score was 4 or 5 (cured or improved) after the operation for 88.2% of patients. CONCLUSIONS: Our hypothesis that the cure effect of Bulkamid® operation would be positive in patients who have undergone previous unsuccessful tape anti-incontinence surgery was partially confirmed. The Likert and VAS scores indicate that the effect of Bulkamid® surgery is good; however, an evaluation of the cure effect of this procedure based on the ICIQ-UI SF score is less positive. This kind of operation, which is minimally invasive, is less arduous for patients, and it is also suitable for patients who have refused further surgical treatment.


Asunto(s)
Resinas Acrílicas/administración & dosificación , Materiales Biocompatibles/administración & dosificación , Hidrogeles/administración & dosificación , Cabestrillo Suburetral , Incontinencia Urinaria de Esfuerzo/cirugía , Adulto , Anciano , Femenino , Humanos , Inyecciones , Persona de Mediana Edad , Estudios Retrospectivos , Encuestas y Cuestionarios , Insuficiencia del Tratamiento , Resultado del Tratamiento
15.
Ultrasound Obstet Gynecol ; 43(4): 365-71, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24615948

RESUMEN

OBJECTIVE: To compare the efficacy of two standard surgical procedures for post-hysterectomy vaginal vault prolapse in patients with levator ani avulsion. METHODS: This was a single-center, randomized interventional trial, of two standard surgical procedures for post-hysterectomy vaginal vault prolapse: Prolift Total vs unilateral vaginal sacrospinous colpopexy with native tissue vaginal repair (sacrospinous fixation, SSF), during the period from 2008 to 2011. Entry criteria included at least two-compartment prolapse, as well as complete unilateral or bilateral levator ani avulsion injury. The primary outcome was anatomical failure based on clinical and ultrasound assessment. Failure was defined clinically, according to the Pelvic Organ Prolapse Quantification system, as Ba, C or Bp at the hymen or below, and on translabial ultrasound as bladder descent to 10 mm or more below the lower margin of the symphysis pubis on maximum Valsalva maneuver. Secondary outcomes were evaluation of continence, sexual function and prolapse symptoms based on validated questionnaires. RESULTS: During the study period, 142 patients who were post-hysterectomy underwent surgery for prolapse in our unit; 72 of these were diagnosed with an avulsion injury and were offered participation in the study. Seventy patients were randomized into two groups: 36 in the Prolift group and 34 in the SSF group. On clinical examination at 1-year follow-up, we observed one (3%) case of anatomical failure in the Prolift group and 22 (65%) in the SSF group (P < 0.001). Using ultrasound criteria, there was one (2.8%) failure in the Prolift group compared with 21 (61.8%) in the SSF group (P < 0.001). The postoperative POPDI (Pelvic Organ Prolapse Distress Inventory) score for subjective outcome was 15.3 in the Prolift group vs 21.7 in the SSF group (P = 0.16). CONCLUSION: In patients with prolapse after hysterectomy and levator ani avulsion injury, SSF has a higher anatomical failure rate than does the Prolift Total procedure at 1-year follow-up.


Asunto(s)
Enfermedades del Ano/cirugía , Procedimientos Quirúrgicos Ginecológicos/métodos , Histerectomía Vaginal/efectos adversos , Dolor/cirugía , Prolapso de Órgano Pélvico/cirugía , Complicaciones Posoperatorias/cirugía , Mallas Quirúrgicas , Vagina/cirugía , Anciano , Enfermedades del Ano/complicaciones , Enfermedades del Ano/diagnóstico por imagen , Coito , Femenino , Humanos , Persona de Mediana Edad , Dolor/complicaciones , Dolor/diagnóstico por imagen , Diafragma Pélvico/cirugía , Prolapso de Órgano Pélvico/diagnóstico por imagen , Prolapso de Órgano Pélvico/etiología , Complicaciones Posoperatorias/diagnóstico por imagen , Encuestas y Cuestionarios , Resultado del Tratamiento , Ultrasonografía , Incontinencia Urinaria de Esfuerzo/etiología , Vagina/diagnóstico por imagen , Vagina/fisiopatología , Maniobra de Valsalva
16.
Ceska Gynekol ; 78(2): 200-5, 2013 Apr.
Artículo en Checo | MEDLINE | ID: mdl-23710986

RESUMEN

OBJECTIVE: Informative review of possible causes and therapy of habitual pregnancy loss and infertility. DESIGN: Review. SETTINGS: Department of Gynecology and Obstetrics, General Faculty Hospital of Charles University, Prague. SUBJECT AND METHOD: The repeated (habitual) loss of pregnancy is defined by three or more spontaneous abortions. Approximately 0,4 to 1% of women are affected. The pregnancy loss is more frequent in women younger than 20 and older than 35 years. The frequency of spontaneous abortions parallels the number of previous pregnancies. The causative treatment of women with recurring abortions is not available, however, it is recommended that such women are evaluated by available methods to eliminate etiological causes of repeated pregnancy losses. CONCLUSIONS: Effective therapy is possible when the diagnostic reason for repeated abortions is determined. Nevertheless, the causes leading to repeated pregnancy losses are identified only in approximately 12% of women. However, alleged and unexplained infertility, resulting in habitual pregnancy losses has a favorable prognosis.


Asunto(s)
Aborto Habitual , Femenino , Humanos , Infertilidad Femenina , Embarazo
17.
Ceska Gynekol ; 78(6): 554-9, 2013 Dec.
Artículo en Checo | MEDLINE | ID: mdl-24372434

RESUMEN

OBJECTIVE: The objective of this study was to evaluate short term and long term efficacy of a transurethral injection (TUI) using bulking agent Bulkamid® for female stress (SUI) and mixed urinary incontinence by women with ISD or where anti-incontinence surgery has failed. DESIGN: Retrospective clinical study. SETTINGS: Gynecological and Obstetric Dpt. 1st Medical Faculty UK and VFN, Prague. MATERIALS AND METHODS: A retrospective study was performed on 52 women with urinary incontinence (stress, 43; mixed 9). One patient died during study. Forty patients had previously undergone anti-incontinence surgery. The efficacy of TUI was evaluated 3 months (± 1 week) and an average of 22 months after surgery. Subjective assessment of the leakage of urine was based on the International Consultation on Incontinence Questionnaire - Short form (ICIQ-UI SF) filled in before, three and - on average - 22 months after the surgery (minimum time after surgery was 6 months). Improvement in urinary incontinence was defined as a drop in the score of more than 50%. Objective assessment of leakage of urine was assessed by cough test. The cure effect was evaluated by VAS (Visual Analogue Scale) score and by using the five-point Likert score. Ethical committee approval was obtained, and all subjects gave written informed consent to participate in the study. RESULTS: Mean age of patients was 70 years, mean body mass index (BMI) 28.65, and mean parity was 1.76. The cough test showed that 19/51 (37.3%) of patients had negative results for this test 3 months and 10/51 (19.6%) 22 months after the operation. The ICIQ-UI SF questionnaire showed that 16/51 (31.4%) of our patients were completely dry 3 months after the operation and 8/51 (15.7 %) 22 months after the operation. 41/51 (80.4%) of patients were dry or improved 3 months after the operation and 23/51 (45.13%) 22 months after the operation. The mean cure effect evaluated by VAS score 3 months after the operation was 72 and 22 months after the operation it was 51.3. The Likert score was 4 or 5 (cured or improved) three and 22 months after operation by 78.4% / 54.9% patients. CONCLUSIONS: The cure effect of Bulkamid® operation decreases in correlation with the time that elapses after the operation, although this procedure is minimally invasive and is an option in cases where anti-incontinence surgery has failed.


Asunto(s)
Resinas Acrílicas/administración & dosificación , Hidrogeles/administración & dosificación , Incontinencia Urinaria de Esfuerzo/terapia , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Materiales Biocompatibles/administración & dosificación , Femenino , Estudios de Seguimiento , Humanos , Inyecciones , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Tiempo , Resultado del Tratamiento , Uretra , Incontinencia Urinaria de Esfuerzo/fisiopatología , Micción , Adulto Joven
18.
Prague Med Rep ; 114(2): 81-91, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23777799

RESUMEN

New mesh-related complications such as erosion, etc., can result from abnormal postoperative healing due to surgical site infection. The aim of our study was to compare systemic inflammatory responses and the incidence of early infectious complications after reconstructive surgery using synthetic mesh and after traditional vaginal wall repair. In this prospective observational study 99 women with symptomatic pelvic organ prolapse were included; 55 women underwent traditional repair and 44 repair using mesh. After the procedure infectious complications were monitored. The patients who underwent reconstructive surgery using mesh material were more likely to have febrile morbidity in the postoperative period than the patients who had been treated with traditional repair (p=0.031); there was a higher incidence of combination febrile morbidity with elevated C-reactive protein (CRP) > 50 mg/l; p=0.046, and a higher incidence of CRP increase over 30 mg/l; p=0.005. Reconstructive procedures using synthetic mesh are accompanied by a higher incidence of early post-operative infectious complications.


Asunto(s)
Infecciones/epidemiología , Inflamación/epidemiología , Prolapso de Órgano Pélvico/cirugía , Mallas Quirúrgicas/efectos adversos , Femenino , Procedimientos Quirúrgicos Ginecológicos/métodos , Humanos , Incidencia , Persona de Mediana Edad , Polipropilenos , Estudios Prospectivos , Factores de Tiempo
19.
Ceska Gynekol ; 77(4): 292-8, 2012 Aug.
Artículo en Checo | MEDLINE | ID: mdl-23094766

RESUMEN

OBJECTIVE OF THE STUDY: The objective of the study is to display the role and importance of ultrasound examination in urogynecology. DESIGN: Literature review. SETTINGS: Department of Gynecology and Obstetrics, First Medical Faculty, Charles University, General Teaching Hospital, Prague. MATERIAL AND METHODS: Presentation of the standards in use of ultrasound imaging in urogynecology and presentation of our practical skills in ultrasound diagnoses in the management of lower urinary tract dysfunctions and in monitoring of the effect of surgical treatment and its complications. CONCLUSIONS: Ultrasound is an excellent method for the investigation of the lower urinary tract, not only as a diagnostic tool but also for the monitoring of the effect of surgical procedures.


Asunto(s)
Enfermedades Urogenitales Femeninas/diagnóstico por imagen , Endosonografía , Femenino , Enfermedades Urogenitales Femeninas/cirugía , Humanos , Pelvis/diagnóstico por imagen , Recto/diagnóstico por imagen , Ultrasonografía/métodos , Vejiga Urinaria/diagnóstico por imagen , Enfermedades de la Vejiga Urinaria/diagnóstico por imagen
20.
Ceska Gynekol ; 77(4): 299-304, 2012 Aug.
Artículo en Checo | MEDLINE | ID: mdl-23094767

RESUMEN

The objective of our work was to summarize tape anti-incontinence operation procedures addressing the stress type of incontinence in women; to evaluate their therapeutic effect and possible peri- or post-operation complications for individual operation procedures. Upon comparison of the selected anti-incontinence operation procedures, to recommend which procedure is preferred under what circumstances.


Asunto(s)
Cabestrillo Suburetral , Incontinencia Urinaria de Esfuerzo/cirugía , Femenino , Humanos , Cabestrillo Suburetral/efectos adversos , Procedimientos Quirúrgicos Urogenitales/efectos adversos , Procedimientos Quirúrgicos Urogenitales/métodos
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