RESUMEN
Vitamin K status was evaluated by measuring blood acarboxyprothrombin (PIVKA-II) levels on the fifth day of life. The incidence of PIVKA-II-positive infants was higher in breast-fed babies than in those given supplementary (mixed) feeding. The median of total amount of milk intake during the first 3 days was significantly lower in PIVKA-II-positive infants than in PIVKA-II-negative infants among infants given both types of feedings. In addition, there was a significant negative correlation between a positive PIVKA-II proportion and the amount of milk intake in the breast-fed babies. The minimum dose of vitamin K2 necessary to prevent a positive PIVKA-II reading was 15 micrograms among babies with a normal absorption potential.
Asunto(s)
Biomarcadores , Lactancia Materna , Leche , Precursores de Proteínas , Vitamina K/administración & dosificación , Vitamina K/sangre , Animales , Relación Dosis-Respuesta a Droga , Alimentos Fortificados , Humanos , Alimentos Infantiles , Recién Nacido , Protrombina/análogos & derivados , Protrombina/sangre , Deficiencia de Vitamina K/sangre , Deficiencia de Vitamina K/prevención & controlAsunto(s)
Anestesia Epidural , Anestesia Obstétrica , Cesárea , Mepivacaína/farmacocinética , Adulto , Femenino , Humanos , EmbarazoRESUMEN
Serum concentration of dantrolene and its active metabolite, 5-hydroxydantrolene were determined in 27 cerebral palsy patients. Correlation coefficients between the oral dose of dantrolene and serum levels of dantrolene and its major metabolite, 5-hydroxydantrolene were rather small in cerebral palsy patients. The mean half-times of dantrolene and 5-hydroxydantrolene were 3.41 (n = 6) and 4.00 (n = 5) hours, respectively. These values were about a half of those reported earlier [Lietman et al., 1974; Meyler et al., 1979; Flewellen et al., 1983]. The poor correlation between serum level and dose may be due to the variation in an extent of oral dantrolene availability.