1.
Clin Transl Radiat Oncol
; 45: 100707, 2024 Mar.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38125648
RESUMEN
â¢Stereotactic body radiation therapy (SBRT) for ultra-central lung tumors is associated with high toxicity rates.â¢To evaluate differences in radiosensitivity within the proximal bronchial tree (PBT), the PBT was sub-segmented into seven anatomical sections.â¢A risk-adapted SBRT regimen of EQD2_10 = 54.4 Gy in 8 or 10 fractions results in excellent local control and low rates of severe toxicity.â¢Data from a recent meta-analysis, the NORDIC Hilus trial and dosimetric data from this study were combined to create a NTCP model.â¢A dose threshold of EQD2_3 = 100 Gy to the PBT or any of its subsegments is expected to result in low rates of severe bronchial toxicity.