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1.
Br J Dermatol ; 185(2): 419-427, 2021 08.
Artículo en Inglés | MEDLINE | ID: mdl-33400272

RESUMEN

BACKGROUND: The prognosis of Sézary syndrome (SS) and mycosis fungoides (MF) depends on lymph node (LN) involvement. The usefulness of LN image-guided core-needle biopsies (CNBs), instead of surgical sampling, has been poorly evaluated. OBJECTIVES: To determine the prognostic value of LN CNB in MF/SS. METHODS: A retrospective search was conducted to identify all LN biopsy specimens of MF/SS between 2008 and 2019. Biopsies were staged according to the International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer (ISCL/EORTC) criteria. We performed immunolabelling and determined the tumour clone frequency (TCF) by high-throughput sequencing of the T-cell receptor beta locus. RESULTS: We included 119 consecutive biopsies from 100 patients, 45 with MF and 55 with SS. N1, N2 and N3 stages were diagnosed in 34 (29%), 26 (22%) and 59 (49%) cases, respectively. The TCF, Ki67 index, and percentage of cells positive for thymocyte selection-associated high mobility group box protein (TOX), programmed cell death protein 1 (PD1), killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) and cluster of differentiation (CD)30 were all positively correlated with the N stage. Median overall survival (OS) for N1/N2 vs. N3 patients was 42 months (range 26-not reached) vs. 14 months (range 5-30), respectively (P < 0·001). In univariate analyses, an age > 75 years, LN short-axis diameter > 15 mm, N3 stage, presence of large-cell transformation, TOX > 60%, PD1 > 25%, Ki67 > 30%, KIR3DL2 > 15%, CD30 > 10% and TCF > 25% were identified as adverse prognostic factors. In multivariate analyses, only an age > 75 years and Ki67 index > 30% were associated with reduced OS. We developed a new prognostic index associating the N stage and the Ki67 index, which better discriminates N3 patients with poor prognosis. CONCLUSIONS: CNB allows an objective assessment of the LN involvement in MF/SS, relevant for staging and prognosis.


Asunto(s)
Micosis Fungoide , Síndrome de Sézary , Neoplasias Cutáneas , Anciano , Biopsia con Aguja , Humanos , Biopsia Guiada por Imagen , Ganglios Linfáticos/patología , Micosis Fungoide/patología , Estadificación de Neoplasias , Pronóstico , Estudios Retrospectivos , Síndrome de Sézary/patología , Neoplasias Cutáneas/patología
4.
Ann Dermatol Venereol ; 145(6-7): 405-412, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29661476

RESUMEN

INTRODUCTION: Adult T-cell leukemia/lymphoma (ATLL) is a hematological malignancy associated with chronic HTLV-1 infection. AIM: To describe skin lesions in ATLL. METHODS: A descriptive, retrospective study between 1996 and 2016, including all patients diagnosed with ATLL at Saint-Louis Hospital (Paris, France). RESULTS: Thirty-seven ATLL patients were included. Fifteen patients (41%) had a cutaneous localization of the disease, which was present from the beginning of the disease for two thirds of them. ATLL types in patients with cutaneous localization of the disease were as follows: lymphoma, n=5, chronic, n=4, smoldering, n=4, acute, n=2. Half the patients had 2 or more cutaneous manifestations. The cutaneous localizations observed were as follows: nodulotumoral (n=8), plaques (n=7), multipapular (n=6), macular (n=4), purpuric (n=2). Among the 15 patients with cutaneous localization, median overall survival was significantly shorter in the acute and lymphoma types compared to the smoldering and chronic types (8.7 months vs. 79 months, P=0.003). DISCUSSION: ATLL is a hematologic malignancy with variable expression that is diagnosed only very rarely in metropolitan France, but that should be sought in patients from countries with high HTLV-1 prevalence in the event of a chronic eruption with patches, papules, plaques and/or tumors. The chronic and smoldering types are relatively indolent, whereas the acute and lymphoma forms have a poor prognosis.


Asunto(s)
Leucemia-Linfoma de Células T del Adulto/complicaciones , Neoplasias Cutáneas/etiología , Adulto , Femenino , Humanos , Leucemia-Linfoma de Células T del Adulto/patología , Masculino , Paris , Estudios Retrospectivos , Neoplasias Cutáneas/patología , Factores de Tiempo
6.
Mult Scler ; 20(8): 1140-2, 2014 07.
Artículo en Inglés | MEDLINE | ID: mdl-24596142

RESUMEN

Kikuchi-Fujimoto disease is a rare systemic disease with uncommon neurological involvement. We report the case of a 30-year-old Asian woman who presented a rapidly progressive loss of vision. Magnetic resonance imaging (MRI) of the optic nerve revealed an inflammation of the left optic nerve with chiasmatic involvement, without any encephalic or medullar lesion. Thoracic computed tomography scan showed bilateral axillary lymphadenopathy. Analysis of a biopsy of the axillary lymph node showed typical histological findings of Kikuchi-Fujimoto disease. There was no clinical or biological sign of associated systemic lupus erythematosus. The patient spontaneously recovered normal visual acuity in 4 weeks, with resolution of MRI abnormalities. No optic neuritis relapse or neurological event occurred in a 3-year follow-up. To our knowledge this is the first case of optic neuritis associated with Kikuchi-Fujimoto disease.


Asunto(s)
Linfadenitis Necrotizante Histiocítica/complicaciones , Neuritis Óptica/etiología , Adulto , Biopsia , Femenino , Linfadenitis Necrotizante Histiocítica/diagnóstico por imagen , Humanos , Imagen por Resonancia Magnética , Neuritis Óptica/diagnóstico por imagen , Neuritis Óptica/fisiopatología , Tomografía Computarizada por Rayos X , Trastornos de la Visión/etiología , Trastornos de la Visión/fisiopatología , Visión Ocular
7.
Clin Infect Dis ; 56(6): 833-42, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-23223599

RESUMEN

BACKGROUND: Castleman disease (CD) in the context of human immunodeficiency virus (HIV) infection is well described. It is almost always multicentric (MCD) and linked to human herpesvirus 8 (HHV-8). There are limited published data surrounding HHV-8-related CD among HIV-negative patients. METHODS: From January 1995 through June 2012, we identified in a single center 18 HIV-seronegative patients with HHV-8-related CD. We report on their clinical, pathological, and laboratory features. RESULTS: All cases were multicentric. Patients were aged 42-83 years and were referred with a relapsing remitting syndrome of fever (94%), constitutional symptoms (100%), peripheral lymphadenopathy (100%), splenomegaly (72%), hepatomegaly (50%), and edema (28%). Kaposi sarcoma was observed in 9 cases. Anemia and serum markers of inflammation were present in all cases. Polymerase chain reaction for HHV-8 DNA was positive on blood samples in all cases, whereas only 12 of 16 patients tested had positive HHV-8 serology at diagnosis. All cases showed the classic histological features of MCD, and LANA-1 immunostaining identified HHV-8-infected plasmablasts in 16 of 16 tested cases. Reactive hemophagocytic syndrome (44%), autoimmune hemolytic anemia (33%), and lymphoma (22%) were the commonest associated complications. Remission was obtained with etoposide in 13 of 15 cases. Rituximab allowed prolonged remission off therapy in 10 cases. Death occurred in 3 patients not treated with rituximab. These features were similar to those described in HIV-positive HHV-8-related MCD. Comparison between these 18 cases and 12 HIV-negative HHV-8-unrelated MCD cases showed marked discrepancies. CONCLUSIONS: HHV-8-associated MCD may be considered as a single clinicopathological entity regardless of HIV status.


Asunto(s)
Enfermedad de Castleman/etiología , Enfermedad de Castleman/patología , Infecciones por Herpesviridae/complicaciones , Infecciones por Herpesviridae/patología , Herpesvirus Humano 8/aislamiento & purificación , Adulto , Anciano , Anciano de 80 o más Años , Anemia , Enfermedad de Castleman/virología , ADN Viral/genética , ADN Viral/aislamiento & purificación , Femenino , VIH , Infecciones por Herpesviridae/virología , Herpesvirus Humano 8/genética , Humanos , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa
9.
Rev Med Interne ; 43(10S1): 10S10-10S16, 2022 Dec.
Artículo en Francés | MEDLINE | ID: mdl-36657938

RESUMEN

Histologically, Castleman's disease associates three subtypes: 1-the vascular hyaline (HV) subtype more often seen in unicentric forms; 2-the plasmacytic (PV) subtype, more frequently associated with the HHV8+ and idiopathic multicentric form; 3-the mixed subtype associating both HV and PV aspects that may be encountered in any type of Castleman's disease. If the diagnosis of unicentric (isolated mass) and multicentric HHV8+ Castleman's disease is easy, the diagnosis of the idiopathic multicentric form remains particularly difficult because it is at the crossroads of many other pathologies (infectious, tumoral and dysimmune), making an anatomoclinical comparison necessary. The role of the pathologist, in the context of disseminated lesions (polyadenopathy and splenomegaly), is to identify lesions that may be part of Castleman's disease, to systematically perform HHV8 testing and to perform complete phenotyping associated with molecular analysis (B and T-cell clonality) in order to rule out a lymphomatous process and certain infectious etilogies. In all cases, its role will be a warning bell and the diagnosis of Castleman's disease will be retained only after a rigorous anatomic and clinical confrontation. © 2022 Published by Elsevier Masson SAS on behalf of Société nationale française de médecine interne (SNFMI).


Asunto(s)
Enfermedad de Castleman , Humanos , Enfermedad de Castleman/diagnóstico , Enfermedad de Castleman/complicaciones , Esplenomegalia
12.
Rev Med Interne ; 40(9): 609-612, 2019 Sep.
Artículo en Francés | MEDLINE | ID: mdl-31221453

RESUMEN

BACKGROUND: Histological diagnosis of systemic granulomatosis may be difficult. The question of the best histological target remains unanswered. CASE: We report here the observation of a patient admitted in intensive care unit for severe hypercalcemia in the context of polylymphadenopathy and constitutional symptoms. Assessment of this hypercalcemia was suggestive of systemic granulomatosis. The CT (computed tomodensitometry) revealed lymphadenopathies of the mediastinum and the hepatic hilus, hepatomegaly and heterogeneous splenomegaly. At this stage, our main hypotheses were: lymphoid hematopathy, sarcoidosis, tuberculosis. An echo-guided biopsy of the spleen allowed the histological diagnosis of systemic granulomatosis suggestive of sarcoidosis, without significant complication in the course. CONCLUSION: This observation illustrates the efficiency and safety of spleen biopsy for the histological diagnosis of systemic granulomatosis.


Asunto(s)
Sarcoidosis/patología , Bazo/patología , Femenino , Humanos , Biopsia Guiada por Imagen/métodos , Persona de Mediana Edad , Ultrasonografía Intervencional
13.
Rev Mal Respir ; 25(2): 173-83, 2008 Feb.
Artículo en Francés | MEDLINE | ID: mdl-18449079

RESUMEN

INTRODUCTION: Non infectious pulmonary complications which frequently occur in the late follow-up of haemopoietic stem cell transplant (HSCT) recipients account for an increase in mortality and morbidity. Different histological entities have been described among which bronchiolitis obliterans is the most common. BACKGROUND: Because of the absence of prospective epidemiological studies and the difficulties in obtaining surgical lung biopsies from these frail patients little is known about these conditions. Although their pathogenesis is poorly understood they probably result from a chronic pulmonary graft versus host disease (GVHD). The introduction of or increase in systemic immunosuppressive treatment, usually indicated for controlling extra-thoracic manifestations of GVHD, may lead to the resolution of an organising pneumonia but is usually ineffective in the treatment of bronchiolitis obliterans. VIEWPOINTS: Current prospective cohort studies together with randomised prospective studies evaluating more targeted treatments should help determine the frequency, the risk factors and the precise characteristics of the different entities of late non-infectious pulmonary diseases following HSCT and should also improve their management. Furthermore, the recent demonstration of lung abnormalities in animal models of chronic GVHD, similar to those observed in humans, should allow a better understanding of the pathogenesis. CONCLUSION: The prevalence of these diseases is increasing throughout the world. More precise analysis, the identification of risk factors and study of the pathophysiological mechanisms involved should allow better understanding and management than at present.


Asunto(s)
Trasplante de Células Madre Hematopoyéticas/efectos adversos , Enfermedades Pulmonares/etiología , Humanos , Huésped Inmunocomprometido , Factores de Riesgo
14.
Arch Pediatr ; 24(5): 471-475, 2017 May.
Artículo en Francés | MEDLINE | ID: mdl-28365190

RESUMEN

Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a rare cause of lymphadenopathy in children. This benign disease can mimic lymphoma and misleads doctors. It was first described in Asia, where it occurred especially in young women. Recent publications show that it can also affect teenagers and young adults in Caucasian populations. The pathophysiology remains unknown. Three hypotheses have been raised for this disease: the role of viruses (in particular HHV-8), genetic predisposition (two alleles in HLA class II genes were found more frequently in patients with Kikuchi disease), and an autoimmune cause because of the correlation with lupus erythematosus. Few cases have been reported in Europe so far. In this article, we report three cases of Kikuchi disease observed in less than 2 months in a single hospital in France. All three patients were teenagers who presented with lymphadenopathy, either isolated or combined with fever, weakness, and weight loss. In all of them, the hypermetabolic activity of the lymph node on the PET scanner misled us to suspect lymphoma. The diagnosis of Kikuchi disease was finally made, for all patients, after 2 weeks in the hospital based on lymph node biopsy. Based on this report, we highlight that early biopsy in presence of lymphadenopathy can avoid unnecessary extensive investigations. Moreover, in this rare disease, it is very surprising to come across three cases that are not family-related, in such a short period of time. This strengthens the hypothesis of the possible implication of an environmental factor in the pathophysiology of Kikuchi disease.


Asunto(s)
Linfadenitis Necrotizante Histiocítica/diagnóstico , Linfoma/diagnóstico , Adolescente , Biopsia , Diagnóstico Diferencial , Femenino , Fluorodesoxiglucosa F18 , Linfadenitis Necrotizante Histiocítica/patología , Humanos , Ganglios Linfáticos/patología , Linfadenopatía/etiología , Linfadenopatía/patología , Linfoma/patología , Masculino , Tomografía de Emisión de Positrones
17.
Rev Med Interne ; 37(1): 53-7, 2016 Jan.
Artículo en Francés | MEDLINE | ID: mdl-26411598

RESUMEN

INTRODUCTION: Multicentric Castleman's disease can mimic adult-onset Still disease. It is exceptionally associated with anasarca, thrombotic microangiopathy and dysautonomia. CASE REPORT: We report a 32-year-old woman with an association of oligoanuria, anasarca, thrombotic microangiopathy with features compatible with adult-onset Still disease. The outcome was initially favorable with corticosteroids, immunoglobulins and plasmapheresis but with the persistence of relapses marked by severe autonomic syndrome and necessity of high dose corticosteroids. The diagnosis of mixed type Castleman's disease, HHV8 and HIV negative, was obtained four years after the onset of symptoms by a lymph node biopsy. The outcome was favorable after tocilizumab and corticosteroids but tocilizumab had to be switched to anakinra to ensure a proper and long-lasting control of the disease. CONCLUSION: Our patient partially fits the description of TAFRO syndrome (Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, Organomegaly), a MCM rare variant, recently described in Japanese patients.


Asunto(s)
Enfermedad de Castleman/patología , Edema/patología , Disautonomías Primarias/patología , Púrpura Trombocitopénica Trombótica/patología , Enfermedad de Still del Adulto/patología , Adulto , Enfermedad de Castleman/complicaciones , Enfermedad de Castleman/diagnóstico por imagen , Diagnóstico Diferencial , Edema/diagnóstico por imagen , Edema/etiología , Femenino , Humanos , Disautonomías Primarias/diagnóstico por imagen , Disautonomías Primarias/etiología , Púrpura Trombocitopénica Trombótica/diagnóstico por imagen , Púrpura Trombocitopénica Trombótica/etiología , Cintigrafía , Enfermedad de Still del Adulto/diagnóstico por imagen , Enfermedad de Still del Adulto/etiología , Síndrome
18.
Clin Infect Dis ; 37(2): 285-91, 2003 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-12856221

RESUMEN

We retrospectively reviewed 5 cases of hemophagocytic lymphohistiocytosis (HL) associated with human herpesvirus 8 (HHV-8) reactivation in human immunodeficiency virus (HIV)-infected patients. All patients had clinical and biological features characteristic of HL. Pulmonary symptoms were present in all patients and were frequently life threatening. The mean number of HL episodes was 6. Four patients had HL-associated Kaposi sarcoma, and 3 had multicentric Castleman disease. The mean CD4 cell count was 200 cells/mm(3). HIV loads were stable in all patients. All patients had high levels of HHV-8 in peripheral blood mononuclear cells during attacks, and a significant increase in this parameter before the attacks was seen in 3 patients. Although 2 patients died of HL, 3 are still alive and receiving etoposide therapy (mean follow-up, 3 years). HHV-8-related HL is associated with life-threatening symptoms and biological HHV-8 reactivation, and it may be controlled in the long term by etoposide therapy combined with highly active antiretroviral therapy.


Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/virología , Infecciones por VIH/complicaciones , Infecciones por Herpesviridae/virología , Herpesvirus Humano 8 , Histiocitosis de Células no Langerhans/virología , Femenino , Infecciones por Herpesviridae/patología , Histiocitosis de Células no Langerhans/patología , Humanos , Masculino , Estudios Retrospectivos
19.
Transplantation ; 72(11): 1838-40, 2001 Dec 15.
Artículo en Inglés | MEDLINE | ID: mdl-11740398

RESUMEN

Toxoplasmosis is a rare but severe complication of bone marrow transplantation. Here, we report three patients in whom toxoplasmic pneumonitis developed, leading to fatal acute respiratory distress syndrome (ARDS). All patients had positive pretransplantation tests for Toxoplasma gondii and were therefore at risk to develop toxoplasmosis reactivation. They all recovered from aplasia, but soon after they died from brutal and severe ARDS. The possible role of an immunopathologic response to T gondii in the lungs in triggering ARDS is discussed.Early screening of parasitemia using highly sensitive polymerase chain reaction methods in seropositive patients with unexplained fever may be needed.


Asunto(s)
Trasplante de Médula Ósea/efectos adversos , Neumonía/complicaciones , Neumonía/parasitología , Síndrome de Dificultad Respiratoria/etiología , Toxoplasmosis/etiología , Enfermedad Aguda , Adulto , Resultado Fatal , Femenino , Humanos , Pulmón/patología , Masculino , Reoperación , Síndrome de Dificultad Respiratoria/patología
20.
Transplantation ; 65(4): 595-7, 1998 Feb 27.
Artículo en Inglés | MEDLINE | ID: mdl-9500643

RESUMEN

Secondary malignancies (lymphomas, leukemias, and solid tumors) occurring after bone marrow transplantation are now more frequently reported, as the patients surviving the early phase of the graft and remaining free of their original disease are more numerous. Besides early Epstein-Barr virus-associated B-cell lymphoproliferative diseases, which are the most common type and most often of donor origin, few late-occurring lymphomas have been described that might represent a distinct entity. We report here a case of Hodgkin's disease developing 8 years after allogeneic bone marrow transplantation for chronic myelogeneous leukemia. Only two Hodgkin's diseases after allogeneic bone marrow transplantation have been reported in the literature so far. The case we report is of interest because of its donor origin and its association with Epstein-Barr virus infection.


Asunto(s)
Trasplante de Médula Ósea/efectos adversos , Enfermedad de Hodgkin/etiología , Leucemia Mielógena Crónica BCR-ABL Positiva/terapia , Neoplasias del Mediastino/etiología , Neoplasias Primarias Secundarias/etiología , Donantes de Tejidos , Adulto , Ciclofosfamida/uso terapéutico , Infecciones por Herpesviridae/patología , Infecciones por Herpesviridae/transmisión , Herpesvirus Humano 4/aislamiento & purificación , Enfermedad de Hodgkin/patología , Humanos , Terapia de Inmunosupresión/métodos , Masculino , Neoplasias del Mediastino/patología , Metotrexato/uso terapéutico , Neoplasias Primarias Secundarias/patología , Infecciones Tumorales por Virus/patología , Infecciones Tumorales por Virus/transmisión , Irradiación Corporal Total
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