RESUMEN
Although cutaneous leishmaniasis lesions usually heal spontaneously they cause unsightly scarring. This study evaluated a possible new therapy in 38 patients, with 70 lesions, randomly assigned to intralesional injection of ciprofloxacin (0.2%) or intralesional sodium chloride hypertonic solution (7%). After excluding patients who defaulted on treatment, lesions assigned to sodium chloride treatment (n = 21) were completely healed (with or without scarring) in 76.2% of cases, and, when a scar remained, the scar size was reduced 66.0% compared with the original lesion. Lesions assigned to ciprofloxacin (n = 27) showed an 81.5% healing rate with an average scar size reduction of 68.6%. Intralesional 0.2% ciprofloxacin was as effective as hypertonic saline in the treatment of cutaneous leishmaniasis infection.
Asunto(s)
Ciprofloxacina/administración & dosificación , Leishmaniasis Cutánea/tratamiento farmacológico , Adolescente , Adulto , Niño , Preescolar , Cicatriz/parasitología , Cicatriz/prevención & control , Femenino , Estudios de Seguimiento , Humanos , Lactante , Inyecciones Intralesiones , Irak , Leishmaniasis Cutánea/complicaciones , Leishmaniasis Cutánea/diagnóstico , Masculino , Persona de Mediana Edad , Solución Salina Hipertónica/administración & dosificación , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Cicatrización de HeridasRESUMEN
Although cutaneous leishmaniasis lesions usually heal spontaneously they cause unsightly scarring. This study evaluated a possible new therapy in 38 patients, with 70 lesions, randomly assigned to intralesional injection of ciprofloxacin [0.2%] or intralesional sodium chloride hypertonic solution [7%]. After excluding patients who defaulted on treatment, lesions assigned to sodium chloride treatment [n = 21] were completely healed [with or without scarring] in 76.2% of cases, and, when a scar remained, the scar size was reduced 66.0% compared with the original lesion. Lesions assigned to ciprofloxacin [n = 27] showed an 81.5% healing rate with an average scar size reduction of 68.6%. Intralesional 0.2% ciprofloxacin was as effective as hypertonic saline in the treatment of cutaneous leishmaniasis infection