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1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32612233
2.
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob Agents Chemother
; 68(4): e0137323, 2024 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38380945
3.
Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent.
Mol Pharm
; 20(12): 6213-6225, 2023 Dec 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-37917742
4.
Forgiveness of INSTI-Containing Regimens at Drug Concentrations Simulating Variable Adherence In Vitro.
Antimicrob Agents Chemother
; 66(5): e0203821, 2022 05 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-35389236
5.
Identification of NK Cell Subpopulations That Differentiate HIV-Infected Subject Cohorts with Diverse Levels of Virus Control.
J Virol
; 93(7)2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30700608
6.
TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells.
Antimicrob Agents Chemother
; 61(1)2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27799218
7.
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.
Antimicrob Agents Chemother
; 60(12): 7086-7097, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27645238
8.
In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile.
Antimicrob Agents Chemother
; 55(4): 1366-76, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21245449
9.
Simulating HIV Breakthrough and Resistance Development During Variable Adherence to Antiretroviral Treatment.
J Acquir Immune Defic Syndr
; 86(3): 369-377, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33196554
10.
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.
Nat Med
; 25(9): 1377-1384, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31501601
11.
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.
Mol Pharmacol
; 74(1): 92-100, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18430788
12.
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.
J Mol Biol
; 363(3): 635-47, 2006 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16979654
13.
Rapid In Vitro Evaluation of Antiretroviral Barrier to Resistance at Therapeutic Drug Levels.
AIDS Res Hum Retroviruses
; 32(12): 1237-1247, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27356854
14.
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.
Antimicrob Agents Chemother
; 49(5): 1898-906, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15855512
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