Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets.

SIGNIFICANCE: The creation of fundamentally new approaches to storing various biomaterial and estimation parameters, without irreversible loss of any biomaterial, is a pressing challenge in clinical practice. We present a technology for studying samples of diabetic and non-diabetic human blood plasma in the terahertz (THz) frequency range. AIM: The main idea of our study is to propose a method for diagnosis and storing the samples of diabetic and non-diabetic human blood plasma and to study these samples in the THz frequency range. APPROACH: Venous blood from patients with type 2 diabetes mellitus and conditionally healthy participants was collected. To limit the impact of water in the THz spectra, lyophilization of liquid samples and their pressing into a pellet were performed. These pellets were analyzed using THz time-domain spectroscopy. The differentiation between the THz spectral data was conducted using multivariate statistics to classify non-diabetic and diabetic groups' spectra. RESULTS: We present the density-normalized absorption and refractive index for diabetic and non-diabetic pellets in the range 0.2 to 1.4 THz. Over the entire THz frequency range, the normalized index of refraction of diabetes pellets exceeds this indicator of non-diabetic pellet on average by 9% to 12%. The non-diabetic and diabetic groups of the THz spectra are spatially separated in the principal component space. CONCLUSION: We illustrate the potential ability in clinical medicine to construct a predictive rule by supervised learning algorithms after collecting enough experimental data.

Design rules for phase-matched terahertz surface electromagnetic wave generation by optical rectification in a nonlinear planar waveguide.

The theory of guided waves in metal-dielectric planar multilayer structures is applied to reduce the loss and maximize optical nonlinearity for efficient terahertz-field generation in a surface electromagnetic wave by femtosecond laser pulses confined in a (chi)((2)) nonlinear planar waveguide. For typical parameters of thin-film polymer waveguides and metal-dielectric interfaces, the optimal size of the (chi)((2)) waveguide core providing the maximum efficiency of terahertz plasmon-field generation is shown to be less than the wavelength of the optical pump field.