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1.
West Afr J Med ; 41(4): 436-451, 2024 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-39003518

RESUMEN

INTRODUCTION: Community-based prevalence studies are known to be more accurate than hospital-based records. However, such community-based prevalence studies are uncommon in low- and middle-income countries including Nigeria. Allocation of resources and prioritization of health care needs by policy makers require data from such community-based studies to be meaningful and sustainable. This study aims to assess the prevalence of common surgical conditions amongst adults in Nigeria. METHODS: A descriptive cross-sectional community-based study to determine the prevalence of congenital and acquired surgical conditions in adults in a mixed rural-urban area of Lagos was conducted. The study population comprised resident members in the Ikorodu Local Government Area (LGA) of Lagos State. Data was collected using a modified version of the interviewer-administered questionnaire, the Surgeons OverSeas Assessment of Surgical Need (SOSAS) survey tool. Data was analysed using the REDCap analytic tool. RESULTS: Eight hundred and fifty-six households were surveyed with a yield of 1,992 adults. There were 95 adults who complained of surgical conditions giving a prevalence rate of 5%. Vast majority of reported conditions were acquired deformities (n=94) while only 1 congenital deformity was reported. Others included breast lumps, anterior neck swelling, and groin swellings. CONCLUSION: The most common surgical complaints in our setting among adults were acquired conditions of the extremities and open wounds/sores. With an estimated population of 90 million adults and approximately 1,200 orthopaedic and general surgeons respectively, the surgeon-to-affected population ratio is 1:10,000. There is a large gap to be filled in terms of surgical manpower development.


INTRODUCTION: Les études de prévalence communautaires sont connues pour être plus précises que les dossiers hospitaliers. Cependant, de telles études de prévalence communautaires sont rares dans les pays à revenu faible et intermédiaire, y compris le Nigeria. L'allocation des ressources et la priorisation des besoins de santé par les décideurs nécessitent des données issues de telles études communautaires pour être significatives et durables. Cette étude vise à évaluer la prévalence des affections chirurgicales courantes chez les adultes au Nigeria. MÉTHODES: Une étude descriptive transversale basée sur la communauté pour déterminer la prévalence des conditions chirurgicales congénitales et acquises chez les adultes dans une zone rurale-urbaine mixte de Lagos a été menée. La population étudiée comprenait des membres résidents de la zone de gouvernement local (LGA) d'Ikorodu, dans l'État de Lagos. Les données ont été collectées à l'aide d'une version modifiée du questionnaire administré par un enquêteur, l'outil d'enquête Surgeons OverSeas Assessment of Surgical Need (SOSAS). Les données ont été analysées à l'aide de l'outil analytique REDCap. RÉSULTATS: Huit cent cinquante-six ménages ont été enquêtés, ce qui a donné 1 992 adultes. Quatre-vingt-quinze adultes se sont plaints de conditions chirurgicales, donnant un taux de prévalence de 5 %. La grande majorité des conditions rapportées étaient des déformations acquises (n=94) tandis qu'une seule déformation congénitale a été signalée. Les autres incluaient des nodules mammaires, des gonflements antérieurs du cou et des gonflements inguinaux. CONCLUSION: Les plaintes chirurgicales les plus courantes dans notre cadre parmi les adultes étaient des conditions acquises des extrémités et des plaies ouvertes/ulcères. Avec une population estimée à 90 millions d'adultes et environ 1 200 chirurgiens orthopédiques et généralistes respectivement, le ratio chirurgien-population affectée est de 1:10,000. Il y a un grand écart à combler en termes de développement de la main-d'œuvre chirurgicale. MOTS CLÉS: Prévalence, Charge de morbidité, Chirurgie, Plaies.


Asunto(s)
Población Rural , Población Urbana , Humanos , Nigeria/epidemiología , Estudios Transversales , Adulto , Femenino , Masculino , Población Rural/estadística & datos numéricos , Persona de Mediana Edad , Población Urbana/estadística & datos numéricos , Adulto Joven , Prevalencia , Encuestas y Cuestionarios , Adolescente , Procedimientos Quirúrgicos Operativos/estadística & datos numéricos , Necesidades y Demandas de Servicios de Salud , Anciano , Evaluación de Necesidades
2.
West Afr J Med ; 39(3): 306-313, 2022 Mar 30.
Artículo en Inglés | MEDLINE | ID: mdl-35381845

RESUMEN

INTRODUCTION: Paediatric trauma remains a major health challenge worldwide. It remains a major reason for hospitalization among children and adolescents around the world, with resultant death or disability. This study was aimed to determine the epidemiology, pattern and outcomes of paediatric injuries presenting at a teaching hospital in Lagos, South-west Nigeria. PATIENTS AND METHODS: This was a prospective observational hospital based study conducted on all paediatric trauma patients below 18 years, who presented at the accident and emergency room of the Lagos University Teaching Hospital (LUTH) over a period of thirteen months. Data analysis was done with Stata v13 (StataCorp. Texas. USA). RESULTS: A total of 154 patients sustained 250 documented injuries. The mean age was 6.8 ± 4.6 years. Male to female ratio was 1.5:1. Children aged 8 years were mostly affected. There was significant statistical association between age of child at injury and the place of injury. (p = 0.021) Most injuries (51.3%) occurred at home followed by the road. Falls accounted for 72 cases (46.8%). Traumatic brain injury was the most common injury sustained. Injuries at home peaked at 5pm and extended to 7pm while injuries from road traffic accidents peaked at two periods; between 7am and 8am and 4pm. Paediatric trauma score predicted death accurately. The crude mortality rate was 5.8%. CONCLUSION: Paediatric trauma scourge is still a health concern. School age children are mostly affected by trauma. Falls were the most common cause of trauma in children and most falls occurred in the home environment. Injuries from road traffic accidents accounted for majority of deaths. The paediatric trauma score predicts mortality in injured children and should be routinely used.


INTRODUCTION: Les traumatismes pédiatriques demeurent un problème de santé majeur dans le monde entier. Il demeure une raison majeure d'hospitalisation chez les d'hospitalisation chez les enfants et les adolescents du monde entier, avec des décès ou un handicap résultant . Cette étude avait pour but de déterminer l'épidémiologie, et les résultats des blessures pédiatriques présentées dans un hôpital universitaire de Lagos, dans le sud-ouest du Nigeria. PATIENTS ET MÉTHODES: Il s'agit d'une étude prospective d'observation menée dans un hôpital sur tous les cas de blessures pédiatriques traumatisés de moins de 18 ans, qui se sont présentés au service des accidents et des urgences du accident et des urgences du Lagos University Teaching Hospital (LUTH) sur une période de treize mois. L'analyse des données a été réalisée avec Stata v13 (StataCorp. Texas. USA). RÉSULTATS: Au total, 154 patients ont subi 250 blessures documentées. L'âge moyen était de 6,8 ± 4,6 ans. Le rapport hommes/ femmes était de 1,5:1. Les enfants âgés de 8 ans étaient les plus touchés. Il existe une association statistique significative entre l'âge de l'enfant au moment de la blessure et le lieu de la blessure. (p = 0,021) La plupart des blessures (51,3 %) sont survenues à la maison, suivies par la route. Les chutes ont représenté 72 cas (46,8 %). Les traumatismes cérébraux est la blessure la plus fréquente. Les blessures à domicile ont atteint un pic à 17 heures et se prolongeant jusqu'à 19 heures, tandis que les blessures dues à des accidents de la route ont atteint un pic à deux périodes : entre 6h et 7h59 et à 16h. Le score de traumatisme pédiatrique permettait de prédire le décès avec précision. Le taux de mortalité brut était de 5,8 %. CONCLUSION: Le fléau des traumatismes pédiatriques reste un problème de santé. Les enfants d'âge scolaire sont les plus touchés par les traumatismes. Les chutes étaient la cause la plus cause la plus fréquente de traumatisme chez les enfants et la plupart des chutes se sont produites dans le environnement. Les blessures dues aux accidents de la route représentent la majorité des décès. Le score de traumatisme pédiatrique permet de prédire la mortalité chez les enfants blessés et devrait être utilisé de manière systématique. Mots clés: Traumatisme, Pédiatrie, Blessures, causes, mortalité, Enfance, Nigeria.


Asunto(s)
Accidentes de Tránsito , Hospitales de Enseñanza , Adolescente , Niño , Preescolar , Servicio de Urgencia en Hospital , Femenino , Humanos , Lactante , Masculino , Nigeria/epidemiología , Estudios Prospectivos , Estudios Retrospectivos
3.
Niger J Med ; 25(2): 134-41, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-29944310

RESUMEN

Background: Mentorship is important in residency training as it is necessary for personal and professional development of the resident trainees. Objectives: This study documents mentorship in orthopaedic residency training programme in Nigeria by assessing the awareness of orthopaedic residents on the role of a mentor, willingness to be mentored and their perceived reasons for the possible lack of mentors/ participation of senior colleagues in a mentorship programme. Method: This was a descriptive cross sectional study of 37 orthopaedic residents attending a revision course of the Faculty of Orthopaedics, National Postgraduate Medical College of Nigeria. Self-administered structured questionnaires were used to collect data. Data obtained was analyzed using SPSS version 21.0. Results: The mean age of the respondent was 34.7 ± 4.7 years. The Male: Female ratio was 19:1. The average number of years already spent in the residency programme by the respondents was 2.8 ± 0.9 years. Only 27% of residents had participated in a mentorship programme since they began residency programme but only half were still being mentored at the time of the study. Sixty-five percent reported no formal mentorship programme in their institutions. However, 73% of the respondents would want a formal mentorship programme in their institution. Ninety percent of the respondents desired to be mentored. Conclusion: Most residents are willing to be mentored. Consultants and trainers should ensure that the trainees are mentored.


Asunto(s)
Actitud del Personal de Salud , Internado y Residencia/organización & administración , Mentores/estadística & datos numéricos , Ortopedia/educación , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Nigeria , Médicos , Encuestas y Cuestionarios
4.
Niger Postgrad Med J ; 19(1): 1-6, 2012 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-22430594

RESUMEN

AIMS AND OBJECTIVES: A descriptive cross-sectional study was carried out to determine the prevalence of cardiovascular risk factors amongst traders in an urban market in Lagos State. SUBJECTS AND METHODS: Tejuosho market, one of the large popular markets was selected from a list of markets that met the inclusion criteria of being major markets dealing in general goods using a simple random sampling technique by balloting. Four hundred (400) traders were selected using a systematic random sampling. Each trader was interviewed with a well-structured questionnaire and had blood pressure and anthropometric measurements (height, weight and body mass index). RESULTS: Female traders made up (74.3%) 297 of the total population. The mean age was 45.48+11.88 and 42.29+10.96 years for males and females respectively. Majority 239 (59.8%) fell within the age range of 35 - 55 years. The cardiovascular risk factors identified and their prevalence rates were hypertension (34.8%), physical inactivity (92%), previously diagnosed diabetes mellitus (0.8%), risky alcohol consumption (1%), cigarette smoking (0.3%) in females and (17.5%) in males, obesity (12.3%) and overweight (39.9%). CONCLUSION: The study recommended that any health promoting, preventive or intervention programme for this population would have to be worked into their market activities if it is to make an impact.


Asunto(s)
Consumo de Bebidas Alcohólicas/epidemiología , Enfermedades Cardiovasculares/epidemiología , Diabetes Mellitus/epidemiología , Hipertensión/epidemiología , Obesidad/epidemiología , Fumar/epidemiología , Adulto , Factores de Edad , Anciano , Presión Sanguínea , Índice de Masa Corporal , Enfermedades Cardiovasculares/etiología , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Nigeria/epidemiología , Prevalencia , Factores de Riesgo , Conducta Sedentaria , Factores Sexuales , Población Urbana/estadística & datos numéricos
5.
Niger Postgrad Med J ; 16(3): 186-92, 2009 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19767904

RESUMEN

BACKGROUND: Bacteraemia is a relatively common event in HIV-infected patients, especially in late infection. Studies in Africa have shown that more than 23% of AIDS patients have bacteraemia but there is paucity of data from Nigeria. METHODS: Blood samples from 67 consecutive patients with AIDS attending the Lagos University Teaching Hospital between April and August 2000 were cultured. Temperature, ESR, Full blood count, and where possible CD4 counts were obtained. Socio-demographic details were also recorded. Thirty apparently healthy people were randomly selected from a low-risk population to act as non-AIDS controls. The Oxoid Signal Blood Culture System was used to investigate bacteraemia. Antibiotic sensitivity tests were carried out on all isolates. RESULTS: Twenty-two (33%) of the 67 AIDS patients were culture positive. Non-typhoidal Salmonella spp (45.5%), coagulase-negative staphylococci (22.7%) and Staphylococcus aureus (18.2%) were most commonly isolated. One isolate each of Klebsiella pneumoniae, Pseudomonas aeruginosa and Bacillus spp were identified. All bacteraemic patients had temperatures above 38 degrees C and white blood cell counts ranged between 2,700-13,500/mm(3). There was a high rate of antibiotic resistance particularly to chloramphenicol, tetracyclines, cotrimoxazole and beta-lactam antibiotics. However, most isolates were still susceptible to gentamicin and the fluoroquinolones. There was no significant difference in the socio-demographics of the bacteraemic AIDS and non-bacteraemic AIDS patients. CONCLUSION: Salmonella spp. were the most common aetiological agent of bacteraemia among AIDS patients seen at the Lagos University Teaching Hospital (LUTH), Nigeria. A high temperature was a pointer to the presence of bactaeraemia while total white blood cell counts were not useful. It is recommended that blood culture should be done for AIDS patients with elevated temperature irrespective of the total white blood cell count.


Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Bacteriemia/etiología , Infecciones por VIH/complicaciones , Adulto , Bacteriemia/complicaciones , Bacteriemia/microbiología , Estudios de Casos y Controles , Farmacorresistencia Microbiana , Femenino , Bacterias Gramnegativas , Bacterias Grampositivas , Infecciones por VIH/microbiología , Hospitales de Enseñanza , Hospitales Universitarios , Humanos , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Nigeria , Adulto Joven
6.
J Clin Pathol ; 31(10): 936-8, 1978 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-101555

RESUMEN

Manganous chloride and Congo red incorporated into blotting paper discs have been used to differentiate gonococci from meningococci. The new technique is simple and reliable; the materials for the test are inexpensive. The method will increase the efficiency of distinguishing between the pathogenic Neisseria in any clinical bacteriology laboratory and especially in those in the tropical areas.


Asunto(s)
Técnicas Bacteriológicas , Rojo Congo , Manganeso , Neisseria gonorrhoeae/efectos de los fármacos , Neisseria meningitidis/efectos de los fármacos , Rojo Congo/farmacología , Farmacorresistencia Microbiana , Humanos , Manganeso/farmacología , Neisseria gonorrhoeae/aislamiento & purificación , Neisseria meningitidis/aislamiento & purificación
7.
J Med Microbiol ; 16(1): 93-6, 1983 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-6822994

RESUMEN

From patients in Nigeria with acute gastroenteritis, strains of Yersinia were isolated from 14 (1.3%) of 1082 specimens of faeces examined specifically for yersiniae by direct plating and after cold enrichment. Clinical significance was ascribed to six isolates of Y. enterocolitica (serotypes 03, 05,27 and 09) but not to seven isolates of Y. intermedia or one isolate of Y. frederikseni.


Asunto(s)
Gastroenteritis/microbiología , Yersinia/aislamiento & purificación , Adolescente , Adulto , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Pruebas de Sensibilidad Microbiana , Nigeria , Yersiniosis/microbiología , Yersinia enterocolitica/aislamiento & purificación
8.
Clin Microbiol Infect ; 9(2): 153-6, 2003 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-12588338

RESUMEN

Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious therapeutic problem worldwide, and its frequency in most African countries has not been reported. This study was aimed at determining the prevalence and antibiotic susceptibility patterns of MRSA in eight large hospitals (>500 beds) in Africa and Malta, from 1996 to 1997. Susceptibility to methicillin (oxacillin) and to other drugs was determined by E test (AB Biodisk, Solna, Sweden) on a total of 1440 clinical isolates of S. aureus. Methicillin resistance was detected in 213 (15%) of the 1440 isolates tested. The rate of MRSA was relatively high in Nigeria, Kenya, and Cameroon (21-30%), and below 10% in Tunisia, Malta, and Algeria. All MRSA isolates were sensitive to vancomycin, with MICs 60%) of MRSA strains were multiresistant. There is a need to maintain surveillance and control of MRSA infections in Africa.


Asunto(s)
Resistencia a la Meticilina , Infecciones Estafilocócicas/epidemiología , Staphylococcus aureus/efectos de los fármacos , África/epidemiología , Resistencia a Múltiples Medicamentos , Humanos , Malta/epidemiología , Pruebas de Sensibilidad Microbiana , Prevalencia
9.
Trans R Soc Trop Med Hyg ; 76(2): 265-7, 1982.
Artículo en Inglés | MEDLINE | ID: mdl-7048653

RESUMEN

Enteropathogenic, enterotoxigenic and enteroinvasive Escherichia coli were isolated from 52 (4.8%) of 1,082 patients with acute gastroenteritis reporting at the Lagos University Teaching Hospital, Lagos, Nigeria between October 1979 and March, 1981. Of the 52 strains of E. coli isolated, 35 (67.3%) were enteropathogenic, 12 (23.1%) were enterotoxigenic and five (9.6%) were enteroinvasive. E. coli 0111 (25.7%) was the most predominant among the serotypes of the "classical" enteropathogenic strains found in this study. Diarrhoea associated with enteropathogenic E. coli occurred only in children aged less than five years, whereas enterotoxigenic and enteroinvasive E. coli were found primarily in adults. The study has highlighted for the first time the important role that enterotoxigenic and enteroinvasive E. coli strains could play in acute diarrhoeal diseases in Lagos, Nigeria.


Asunto(s)
Infecciones por Escherichia coli/microbiología , Escherichia coli/aislamiento & purificación , Gastroenteritis/microbiología , Adolescente , Adulto , Niño , Preescolar , Enterotoxinas/análisis , Escherichia coli/clasificación , Heces/microbiología , Humanos , Lactante , Persona de Mediana Edad , Nigeria , Serotipificación
10.
East Afr Med J ; 74(6): 389-91, 1997 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9487403

RESUMEN

The adherence capacity of Candida species to female vaginal epithelial cells was examined. The results showed that in four groups of patients studied, the highest adherence was with epithelial cells collected from pregnant diabetic women (47% adherence, and 1,700 adherent yeasts). Pregnant or diabetic women had 39% each of adherence to epithelial cells but differed in the number of adherent yeasts (1,400 and 1,000 respectively). The diabetic and pregnant women therefore appeared differential attachment to epithelial cells from different physiologically adapted women.


Asunto(s)
Candida albicans/fisiología , Vagina/microbiología , Estudios de Casos y Controles , Adhesión Celular , Diabetes Mellitus/fisiopatología , Susceptibilidad a Enfermedades , Epitelio/microbiología , Femenino , Humanos , Embarazo/fisiología , Embarazo en Diabéticas/fisiopatología
11.
West Afr J Med ; 21(3): 226-9, 2002.
Artículo en Inglés | MEDLINE | ID: mdl-12744574

RESUMEN

Acinetobacter spp are well recognised as causes of nosocomial infections particularly in patients with immature or defective body defence system. Information concerning these organisms are lacking in this environment. For this reason the pattern of infection and the antimicrobial susceptibility profiles of these organisms isolated over a one-year period were studied. A total of 58 (3%) of the 2001 isolates from all clinical specimens received in the laboratory during the year were Acinetobacter spp. The 58 Acinetobacter spp constituted 5.5% of all the 1051 NLF-GNB isolated, and caused 4.6% of all the 1261 nosocomial infections. Thirty-seven (63%) and 17 (30%) of the Acinetobacter isolates were from wound infections and UTI respectively. All the infections were nosocomially acquired and were associated with compromised host immunity, defective body defence, surgery or urinary catheterization; with Acinetobacter baumannii being the predominant species. There was an apparent male predominance over females by a ratio of 1. 9:1 in the infections, particularly from 45 years and above. One hundred percent and 96.6% of the isolates were susceptible to cefoperazone-sulbactam and travofloxacin respectively. Forty-five (77.6%) were susceptible to cefotaxime, 49 (84.5%) to ampicillin-sulbactam, 34 (58.6%) to ceftazidime, 38 (65.6%) to ticarcillin-clavulanic acid and 41 (70.7%) to ciprofloxacin. Generally the Acinetobacter spp showed multiple resistance to the range of antibiotics tested. All the isolates produced beta-lactamase.


Asunto(s)
Infecciones por Acinetobacter/epidemiología , Infecciones por Acinetobacter/microbiología , Infecciones por Acinetobacter/tratamiento farmacológico , Adolescente , Adulto , Distribución por Edad , Niño , Preescolar , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/epidemiología , Infección Hospitalaria/microbiología , Farmacorresistencia Bacteriana Múltiple , Femenino , Hospitales Universitarios , Humanos , Huésped Inmunocomprometido , Lactante , Recién Nacido , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Nigeria/epidemiología , Vigilancia de la Población , Prevalencia , Factores de Riesgo , Serotipificación , Distribución por Sexo , Infecciones Urinarias/tratamiento farmacológico , Infecciones Urinarias/epidemiología , Infecciones Urinarias/microbiología , Infección de Heridas/tratamiento farmacológico , Infección de Heridas/epidemiología , Infección de Heridas/microbiología
12.
West Afr J Med ; 17(3): 136-9, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-9814079

RESUMEN

105 consecutively admitted neonates with tetanus were screened for sepsis to determine the prevalence of sepsis in neonatal Tetanus (NNT) patients and identify the bacterial pathogens causing septicaemia in them. The presence of omphalitis, poor colour, hypothermia and hyperthermia were found to be sensitive predictors of septicaemia in NNT patients. 50 bacterial pathogens were isolated from 50 babies. Klebsiella pneumoniae (20.7%), and Enterobacter cloacae (19.0%) were the leading gram negatives, while staphylococcus aureus (19.2%) was the prevalent gram positive organism isolated. Antimicrobial susceptibility profile heavily favours ofloxacin but a combination of cloxacillin and gentamicin is recommended as first line. Ceftazidime with about 60% susceptibility across board is the favoured cephalosporin.


Asunto(s)
Bacteriemia/complicaciones , Bacteriemia/microbiología , Tétanos/complicaciones , Antibacterianos/uso terapéutico , Bacteriemia/tratamiento farmacológico , Estudios de Casos y Controles , Femenino , Humanos , Recién Nacido , Masculino , Pruebas de Sensibilidad Microbiana , Tamizaje Neonatal , Valor Predictivo de las Pruebas , Prevalencia , Pronóstico
13.
West Afr J Med ; 17(3): 168-72, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-9814086

RESUMEN

One hundred and fifty five neonates with conjunctivitis admitted into the neonatal unit at the Lagos University Teaching Hospital were microbiologically investigated. This was to determine the bacterial aetiologic agent(s) in neonatal eye infection and highlight some risk factors. Antimicrobial susceptibility testing was done on the pathogens isolated using the diskagar diffusion method. The incidence of conjuctivitis in the newborn was 18 per 1000 live births. Predisposing factor noted were vaginal delivery, asphyxia neonatorum and prolonged rupture of membrane. Pathogens predominantly isolated were Staphylococcus aureus (37.4%), Coagilase negative Staphylococci (12.3%), Klebsiella pneumoniae (12.9%) and Pseudomonas aeruginosa (8.2%). Antimicrobial suscepibility results revealed varied degrees of susceptibility to ofloxacin (75%), Cloxacillin, erythromycin, Gentamicin and augumentin (30%) by the gram positive bacteria while most of the gram negative were susceptible to colistin and ofloxacin (above 90%). The high incidence of bacterial eye infection should be minimized by the elimination of the risk factors and adoption of stringent aseptic measures in the care of the neonate.


Asunto(s)
Conjuntivitis Bacteriana/microbiología , Infección Hospitalaria/microbiología , Farmacorresistencia Microbiana , Femenino , Hospitales Universitarios , Humanos , Incidencia , Recién Nacido , Control de Infecciones , Unidades de Cuidado Intensivo Neonatal , Masculino , Pruebas de Sensibilidad Microbiana , Estudios Prospectivos , Factores de Riesgo
14.
Afr J Med Med Sci ; 19(1): 1-3, 1990 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-2109513

RESUMEN

Two cases of meningococcal disease due to serogroup W-135 Neisseria meningitidis are presented. One died from fulminating meningococcaemia and the other had severe meningoencephalitis with acute septic arthritis. Serogroup W-135 N. meningitidis is pathogenic for man, and laboratories should attempt to identify and serotype the organism so that more data about the disease it causes can be obtained.


Asunto(s)
Infecciones Meningocócicas/diagnóstico , Niño , Preescolar , Femenino , Humanos , Masculino , Infecciones Meningocócicas/clasificación , Infecciones Meningocócicas/epidemiología , Neisseria meningitidis , Nigeria/epidemiología , Serotipificación
15.
Afr J Med Med Sci ; 13(1-2): 15-20, 1984.
Artículo en Inglés | MEDLINE | ID: mdl-6087634

RESUMEN

Two hundred and ninety-six bacterial isolates were investigated for the effects of saliva and alpha-amylase on their susceptibility to ampicillin, tetracycline, chloramphenicol and gentamicin. When the test organisms were primed with normal and 'diseased' saliva there were no observable differences in the MICs of ampicillin and chloramphenicol for group-A streptococci, but alpha-amylase significantly reduced the MIC of tetracycline from 2 to 0.25 mg/1. With Staphyloccus aureus, priming with saliva and alpha-amylase had no effect on the MICs of gentamicin and ampicillin, whereas the MICs of tetracycline and chloramphenicol were increased. The effect of saliva on the susceptibility of E. coli to tetracycline was also significant; MIC50 and MIC90 were reduced from 128 to 8 and 32 mg/1 respectively. Chloramphenicol was however increased from less than 0.125 to 1 and 2 mg/1 when E. coli was primed with amylase and saliva respectively. The general significance of these observations is discussed.


Asunto(s)
Antibacterianos/farmacología , Bacterias/efectos de los fármacos , Saliva/inmunología , alfa-Amilasas/inmunología , Ampicilina/farmacología , Cloranfenicol/farmacología , Escherichia coli/efectos de los fármacos , Gentamicinas/farmacología , Humanos , Pruebas de Sensibilidad Microbiana , Proteus mirabilis/efectos de los fármacos , Pseudomonas aeruginosa/efectos de los fármacos , Shigella boydii/efectos de los fármacos , Staphylococcus aureus/efectos de los fármacos , Streptococcus pyogenes/efectos de los fármacos , Tetraciclina/farmacología
16.
Niger Postgrad Med J ; 9(4): 210-3, 2002 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-12690681

RESUMEN

Beta-lactamase production was investigated in 1033 bacterial pathogens--262 gram-positive bacteria, 482 Enterobacteriaceae, 289 non-fermenting bacilli. These were isolated from nosocomial infections in paediatric patients. Beta-lactamase was detected using chromogenic cephalosporin and starch paper methods. More than 80% of the isolates produced the enzyme, which was not detected in enterococci and streptococci. There was no appreciable difference ([symbol: see text] 2 = 5.31, P > 0.05) in the number of Beta-lactamase producers obtained using the two methods. Great caution must be exercised in the therapeutic use of Beta-lactam drugs for nosocomial bacterial infections.


Asunto(s)
Infecciones Bacterianas/epidemiología , Infecciones Bacterianas/microbiología , Infección Hospitalaria/epidemiología , Infección Hospitalaria/microbiología , Resistencia betalactámica , beta-Lactamasas/análisis , Antibacterianos/uso terapéutico , Infecciones Bacterianas/tratamiento farmacológico , Niño , Infección Hospitalaria/tratamiento farmacológico , Infecciones por Enterobacteriaceae/tratamiento farmacológico , Infecciones por Enterobacteriaceae/epidemiología , Infecciones por Enterobacteriaceae/microbiología , Infecciones por Bacterias Grampositivas/tratamiento farmacológico , Infecciones por Bacterias Grampositivas/epidemiología , Infecciones por Bacterias Grampositivas/microbiología , Hospitales Universitarios , Humanos , Pruebas de Sensibilidad Microbiana/métodos , Pruebas de Sensibilidad Microbiana/normas , Nigeria/epidemiología , Selección de Paciente , Vigilancia de la Población , Infecciones por Pseudomonas/tratamiento farmacológico , Infecciones por Pseudomonas/epidemiología , Infecciones por Pseudomonas/microbiología , Sensibilidad y Especificidad
17.
Niger Postgrad Med J ; 9(3): 125-8, 2002 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-12501265

RESUMEN

Enterococcus faecalis is the most common of the Enterococcus genus causing infection, particularly urinary tract infections, worldwide. It is also a common cause of nosocomial infections and resistance to various antibiotics is on the increase worldwide. Thirty-five strains of E. Faecalis isolated from various clinical specimens (blood, wound swabs endocervical swabs but mostly urine) were screened for high-level aminoglycoside resistance. Their susceptibility nine antibiotics (ampicillin, gentamicin, streptomycin, vancomycin, tetracycline cotrimoxazole and chloramphenicol, ciprofloxacin and erthromycin) was also determined. All isolates were susceptible to Ampicillin and Vancomycin with MIC90 of 4microg/ml but resistant to Nalidixic acid with an MIC90>256microg/ml. Four (11%) of the isolates showed high-level resistance to Gentamicin while 11(32%) exhibited high-level resistance streptomycin after 24 hours incubation. It will appear that Ampicillin in combination with gentamicin but not streptomycin, can still be used empirically for the treatment of Enterococcal infections.


Asunto(s)
Antibacterianos , Quimioterapia Combinada/uso terapéutico , Enterococcus faecalis/efectos de los fármacos , Infecciones por Bacterias Grampositivas/tratamiento farmacológico , Enterococcus faecalis/aislamiento & purificación , Humanos , Pruebas de Sensibilidad Microbiana , Nigeria
18.
Niger Postgrad Med J ; 11(1): 4-9, 2004 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15254564

RESUMEN

This study was undertaken to determine nosocomial bacterial infections (NI) in surgical patients in a developing country using the detailed option of the Center for Disease Control (CDC) surgical patient surveillance technique. From 1994 - 1995. Paediatrics surgical patients at the Lagos University Teaching Hospital (LUTH) were prospectively monitored for NI at all body sites. Standard definitions of NI were used, and NI sites were categorised by type of operation. A total of 304 NI occurred in 245 out of 664 surgical patients investigated. SSI (77.3 %) and urinary tract infections (19.1%) were in preponderance. Seventy three per cent of SSI were superficial incisions, 20.5% organ/space and 6.8% deep incisions. The overall wound infection rate was 30.9%. The SSI rate for emergency surgery was 35.6% and 26.5% for elective procedures. Rates within each wound class were 20.2, 23.8, 51.9 and 52.8% respectively and 17, 37.6, 43.4 and 47. 1% for patients with ASA scores of I II III and IV in that order. The SSI rates for patients with scores of 0, 1, 2 and 3 were 20.4; 43.5, 57.1 and 75% respectively. Mean infection rates in the various wound classes were highly correlated with the number of risk factors present. Klebsiella pneumoniae (38. 7%), Escherichia coli (22.7%), Pseudomonas aeruginosa (16.8%) and Staphylococcus aureus (10. 7%) were the most common pathogens.


Asunto(s)
Bacterias Aerobias , Infecciones Bacterianas/epidemiología , Infección Hospitalaria/epidemiología , Hospitales Universitarios/estadística & datos numéricos , Servicio de Cirugía en Hospital/estadística & datos numéricos , Niño , Femenino , Humanos , Masculino , Nigeria/epidemiología , Vigilancia de la Población , Procedimientos Quirúrgicos Operativos/estadística & datos numéricos
19.
Nig Q J Hosp Med ; 20(3): 138-43, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-21033323

RESUMEN

BACKGROUND: There is a dearth of information on postoperative eye infections in Nigeria and most hospitals do not have an infection control program in place. OBJECTIVE: This study was done to investigate the incidence of post-operative eye infections, their potential sources and the preparedness of the hospital to prevent such infections. METHODS: A microbiological survey of all eye surgical procedures between March 2004 and May 2005 was performed. Relevant samples were taken and cultured pre, intra and post operatively as required. Definitions of infections were based on the Centers for Disease Control (CDC) Criteria. In the eye clinic, and operation theatre, infection control procedures and practices were audited using a pre-designed questionnaire. RESULTS: There were 2 cases of post operative eye infections (with Haemophilus influenzae and Corynebacterium species) during the one year of survey of 339 performed surgeries. S. aureus, Coagulase negative staphylococcus (CNS), and Enterobacter spp were cultured from the aqueous humour, as well as pre and post operative conjunctivae swabs of three other patients. Eighty four (24.8%) other patients were colonized post operatively with CNS (32), S. aureus (28), Klebsiella pneumoniae (8), E. coli (5), Corynebacterium species (3), Pseudomonas aeruginosa (1) Proteus mirabilis (4), Enterobacter species alone (1) and in association with CNS on 2 occasions. Seventy eight percent of patients had contact with staff who consistently haboured Staphylococcus species in their nares. Four patients (0.11%) were exposed to surgeons whose hands were contaminated and one eye (0.003%) to contaminated antiseptic solution. Facilities for hand washing and protective clothing were adequate but staffs were observed to perform an inadequate hands scrubbing. Most items were heat sterilized. Cleaning facilities were adequate and the environment was clean. The choice of antiseptic was correct, but that of disinfectant was considered incorrect. The ophthalmic equipments except the eye occluder were appropriately disinfected. Staffs were not protected when handling linen. Infected linens were separated from soiled linens only in the theatre. They were not bagged, and were hand sluiced. The only type of waste that was properly handled was sharps. All waste types were stored together prior to final disposal away from the public. CONCLUSION: The incidence of post-operative infection was 1.69% and their sources were the patients' normal flora. Other potential sources of post-operative eye infections identified included nares of hospital staff, hands of surgeon and hospital disinfectants. Areas of deficiencies in infection control practices, which require proper infection control policies, include hand scrubbing practices, disinfection, linen management and waste handling.


Asunto(s)
Infección Hospitalaria/epidemiología , Infecciones del Ojo/epidemiología , Control de Infecciones/métodos , Infección de la Herida Quirúrgica/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Infección Hospitalaria/microbiología , Desinfección , Infecciones del Ojo/etiología , Infecciones del Ojo/microbiología , Femenino , Bacterias Gramnegativas/aislamiento & purificación , Bacterias Grampositivas/aislamiento & purificación , Desinfección de las Manos , Hospitales Privados , Humanos , Incidencia , Lactante , Masculino , Auditoría Médica , Persona de Mediana Edad , Nigeria/epidemiología , Nariz/microbiología , Personal de Hospital , Periodo Posoperatorio , Infección de la Herida Quirúrgica/microbiología , Adulto Joven
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