A Survey on 5G and LPWAN-IoT for Improved Smart Cities and Remote Area Applications: From the Aspect of Architecture and Security.

Addressing the recent trend of the massive demand for resources and ubiquitous use for all citizens has led to the conceptualization of technologies such as the Internet of Things (IoT) and smart cities. Ubiquitous IoT connectivity can be achieved to serve both urban and underserved remote areas such as rural communities by deploying 5G mobile networks with Low Power Wide Area Network (LPWAN). The current architectures will not offer flexible connectivity to many IoT applications due to high service demand, data exchange, emerging technologies, and security challenges. Hence, this paper explores various architectures that consider a hybrid 5G-LPWAN-IoT and Smart Cities. This includes security challenges as well as endogenous security and solutions in 5G and LPWAN-IoT. The slicing of virtual networks using software-defined network (SDN)/network function virtualization (NFV) based on the different quality of service (QoS) to satisfy different services and quality of experience (QoE) is presented. Also, a strategy that considers the implementation of 5G jointly with Weightless-N (TVWS) technologies to reduce the cell edge interference is considered. Discussions on the need for ubiquity connectivity leveraging 5G and LPWAN-IoT are presented. In addition, future research directions are presented, including a unified 5G network and LPWAN-IoT architecture that will holistically support integration with emerging technologies and endogenous security for improved/secured smart cities and remote areas IoT applications. Finally, the use of LPWAN jointly with low earth orbit (LEO) satellites for ubiquitous IoT connectivity is advocated in this paper.

Exogenous heat shock proteins HSPA1A and HSPB1 regulate TNF-α, IL-1ß and IL-10 secretion from monocytic cells.

Endogenous molecules, such as heat shock proteins (HSP), can function as danger signals when released into the extracellular environment in response to cell stress, where they elicit an immune response such as cytokine secretion. There has also been some suggestion that contamination of exogenous HSPs with lipopolysaccharide (LPS) may be responsible for these effects. This study investigates the effects of exogenous HSPA1A and HSPB1 on the activation of immune cells and the resulting secretion of cytokines, which are involved in inflammatory responses. To address whether exogenous HSPs can directly activate cytokine secretion, naïve U937 cells, differentiated U937 cells and peripheral blood mononuclear cells (PBMCs) were treated with either exogenously applied HSPA1A or HSPB1 and then secreted IL-1ß, TNF-α and IL-10 were measured by ELISA. Both HSPs were able to induce a dose-dependent increase in IL-10 secretion from naïve U937 cells and dose-dependent IL-1ß, TNF-α and IL-10 secretion were also observed in differentiated U937 cells and PBMCs. We also observed that CD14 affects the secretion levels of IL-1ß, TNF-α and IL-10 from cells in response to exogenous HSP treatment. In addition, HSPA1A and HSPB1 were shown to interact with CD14, CD36 and CD11b extracellular receptor proteins. Several approaches used in this study indicate that HSP-induced cytokine secretion is largely independent of any contaminating LPS in the samples.

Short-term energy drink consumption influences plasma glucose, apolipoprotein B, body mass index and pulse rate among students.

OBJECTIVE: Energy drinks are becoming more popular every year, particularly among young adults such as college students, despite evidence that they have harmful health effects. The effect of energy drink consumption on plasma glucose, serum apolipoproteins, and triglyceride levels in students was investigated. METHODS: In order to test this, we chose two representative types of energy drinks in Nigeria, namely fearless and predator. These energy drinks are brand names of non-alcoholic beverages aimed to provide energy. 30 students, apparently healthy male human subjects aged 18 to 30 years who gave informed consent to the research work were randomly selected and divided into two groups: Group A (fearless energy drink consumers, n=15) and Group B (predator energy drink consumers, n=15).   RESULTS: The results demonstrated significant reductions in pulse rate (86.00±41.32 vs. 78.87±27.72; p=0.03) and BMI (21.41±1.93 vs. 21.7±12.02; p=0.00) as compared to baseline values after one month of "fearless energy drink" consumption. Plasma glucose levels were significantly higher (97.53±10.62 vs. 88.80±11.33; p=0.01) and Apo B levels were significantly lower (21.41±1.93 vs. 21.71±2.02; p=0.00) following two weeks of fearless energy drink consumption than in baseline. In addition, BMI and Apo B levels were significantly lower after two weeks of predator energy drink consumption, but plasma glucose levels were significantly higher after two weeks and one month of predator energy drink consumption, respectively (p<0.05). SBP, DBP, TG and Apo A levels did not differ significantly in both fearless and predator energy drink consumers at baseline and after the study period respectively (p>0.05). CONCLUSION: This study has shown that the consumption of energy drinks causes significant alterations in BMI, pulse rate, plasma glucose and apolipoprotein B levels which may have important clinical consequences for energy drink consumers.