Coexistence of extensive calcification and membrano-cystic changes in lupus erythematosus panniculitis associated with systemic lupus erythematosus.

We report a case of lupus erythematosus panniculitis with long-standing systemic lupus erythematosus. The patient developed widespread calcification and membrano-cystic changes in the subcutaneous tissue. There have been no reports of the coexistence of calcification and membrano-cystic changes in the literature. The mechanism for the coexistence of the calcification and membrano-cystic changes might be due to the degenerative changes in fat cells from local circulatory disturbance.

Co-existence of pemphigus vulgaris and Hashimoto's thyroiditis.

We report a case of pemphigus vulgaris (PV) associated with Hashimoto's thyroiditis. Direct immunofluorescent studies revealed intercellular deposits of IgG and C3. Both anti-desmoglein (Dsg) 1 and Dsg 3 antibodies were positive in the patient's serum by enzyme-linked immunosorbent assays. HLA genotyping was performed from the patient's peripheral blood leukocytes by polymerase chain reaction. HLA-A*02011, -A*2402101, -DQA1*0104, -DQB1*05031 and -DRB1*1405 alleles, which confer strong susceptibility to Japanese patients with PV, were found. HLA-DQA1*0303 which is strongly associated with Hashimoto's thyroiditis in the Japanese population was also determined.

Spontaneous regression of multiple tumoral calcinosis in a child.

We report a case of multiple tumoral calcinosis on the head and back of a one-year-old boy who had no renal diseases. After an excisional biopsy of one of the tumors from the occipital region, all of the tumors spontaneously regressed without any further surgical or medical treatment. Although he had neonatal hepatitis, his liver function improved as well as the course of the spontaneous regression of the tumoral calcinosis. There has been only one case of a child with this condition in the literature.