Peritoneal carcinomatosis after minimally invasive surgery versus open radical hysterectomy: systematic review and meta-analysis.

OBJECTIVE: To assess the incidence of peritoneal carcinomatosis in patients undergoing minimally invasive or open radical hysterectomy for cervical cancer. METHODS: The MEDLINE (accessed through Ovid), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Clinical Trials, and Scopus databases were searched for articles published from inception up to April 2022. Articles published in English were considered. The included studies reported on patients with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA-IIA squamous cell carcinoma, adenocarcinoma, and/or adenosquamous carcinoma of the cervix who underwent primary surgery. Studies had to report at least one case of peritoneal carcinomatosis as a recurrence pattern, and only studies comparing recurrence after minimally invasive surgery versus open surgery were considered. Variables of interest were manually extracted into a standardized electronic database. This study was registered in PROSPERO (CRD42022325068). RESULTS: The initial search identified 518 articles. After the removal of the duplicate entries from the initial search, two authors independently reviewed the titles and abstracts of the remaining 453 articles. Finally, 78 articles were selected for full-text evaluation; 22 articles (a total of 7626 patients) were included in the analysis-one randomized controlled trial and 21 observational retrospective studies. The most common histology was squamous cell carcinoma in 60.9%, and the tumor size was <4 cm in 92.8% of patients. Peritoneal carcinomatosis pattern represented 22.2% of recurrences in the minimally invasive surgery approach versus 8.8% in open surgery, accounting for 15.5% of all recurrences. The meta-analysis of observational studies revealed a statistically significant higher risk of peritoneal carcinomatosis after minimally invasive surgery (OR 1.90, 95% CI 1.32 to 2.74, p<0.05). CONCLUSION: Minimally invasive surgery is associated with a statistically significant higher risk of peritoneal carcinomatosis after radical hysterectomy for cervical cancer compared with open surgery.

Biofortification of pea (Pisum sativum L.): a review.

Biofortification refers to an approach to increase micronutrient concentrations in the edible parts of plants with increased bioavailability to the human population. Conventional, agronomic and transgenic breeding methods can be used to develop these biofortified crops, offering sustainable and cost-effective strategies. Pea has long been recognized as a valuable, nutritious food for the human diet, but there is a limited amount of information about it, which prevents the full micronutrient enrichment potential of this pulse crop to be reached. Considerations must include not only micronutrient concentrations but also the amount of the nutrient that can be absorbed by the consumer, after processing and cooking. Development of biofortified pea that retains nutrients during cooking and processing is not only essential for fighting micronutrient malnutrition, but also necessary to improve agricultural productivity. © 2021 Society of Chemical Industry.

Congenital Chikungunya Virus Infection in Sincelejo, Colombia: A Case Series.

Congenital chikungunya virus (CHIK) infection has been infrequently reported, even more so during the current 2013-15 outbreak in Latin America. In this study, the consequences of CHIK on pregnancy outcomes and particularly consequences in infants born to infected women were assessed in a case series from a single private institution in the north of Colombia. During September 2014 to February 2015, seven pregnant women with serological and reverse transcription-polymerase chain reaction-positive test for CHIK delivered eight infants with CHIK. These newborns required admission to pediatric intensive care, and related support, owing to severe clinical manifestations, which included respiratory distress, sepsis, necrotizing enterocolitis, meningoencephalitis, myocarditis, edema, bullous dermatitis and pericarditis. There were three deaths (case fatality rate of 37.5%). Pregnant women and newborns with CHIK long term should be followed up, given the implications of chronic sequelae (e.g. chronic inflammatory rheumatism in women) as well as recently described neurocognitive impairment in infants.

Perfil del paciente asmático que acude a la emergencia (EMG) del Instituo de Salud del Niño (ISN) por crisis de asma aguda / Profile of the asthmatic patient who comes to the emergency (EMG) of the Institute of Health of the Child (ISN) for crisis of sharp asthma

El presente es un estudio prospectivo de una muestra al azar de 90 pacientes que acudieron a la EMG de ISN en 4 meses de observación (agosto a noviembre de 1999) por ataque de asma agudo. Se tomó los datos de los pacientes mayores de 2 años de edad que ingresaban por crisis asmática para tratamiento ambulatorio y/o hospitalario en una ficha clínica especialmente preparada para tal fin y posteriormente al tratamiento (de acuerdo a los lineamientos del consenso de Asma Bronquial del Colegio Médico del Perú). Se tomó contacto con los familiares de estos para saber la evolución clínica a los 7 días de dicho episodio. Se encontró una predominancia del sexo masculino y de el grupo etáreo de 5 a 9 años en el grupo estudiado. El tipo de crisis según el score de Bearman y Pearson fue predominantemente moderado (53.3 por ciento) y leve (44.4 por ciento). La mayoría de pacientes había iniciado su crisis entre 12 horas a 24 horas antes de acudir a emergencia (45.9 por ciento), pero no existió correlación entre el score clínico de inicio y el número de horas de crisis. Los pacientes en su mayoría habían recibido tratamiento inadecuado en sus hogares antes de acudir a emergencia (73.3 por ciento). Se encontró antecedentes de atopía en la mayoría de pacientes (70 por ciento) y antecedentes de hospitalización anterior por asma en sólo 32.2 por ciento. La edad de diagnóstico de asma dado por un facultativo fue de menos de 4 años en 62.2 por ciento. La edad de inicio de enfermedad, los antecedentes familiares y las hospitalizaciones anteriores no estaban asociadas a la severidad de la crisis al momento del ingreso al estudio. De los 90 pacientes 7 fueron hospitalizados, 5 el mismo día del estudio por Status Asmático Broconeumonía sobreagregada y 2 por recaída días después. El porcentaje de hospitalizaciones fue de 7.77 por ciento y de recaídas 2.35 por ciento. ...