RESUMEN
This study investigates the impact of the COVID-19 pandemic on consumer booking behavior in the peer-to-peer accommodation sector. This study used a dataset composed of 2041,966 raws containing 69,727 properties located in all 21 Italian regions in the pre- and post-COVID-19. Results show that in the pre-COVID-19 period, consumers preferred P2P accommodations with price premiums and located in rural (versus urban) areas. Although the findings reveal a preference for entire apartments over shared accommodation (i.e., room, apartment), this preference did not change significantly after COVID-19 lockdowns. The contribution of this study lies in combining psychological distance theory and signaling theory to assess P2P performance in the pre- and post-COVID-19 periods.
RESUMEN
The efficacy of the very low frequency electromagnetic field in cancer treatment remains elusive due to a lack of explanatory mechanisms for its effect. We developed a novel thermodynamic model that calculates for every cell type the frequency capable of inhibiting proliferation. When this frequency was applied to two human cancer cell lines, it reduced their growth while not affecting healthy cells. The effect was abolished by the inhibition of calcium fluxes. We found evidences of an enhanced respiratory activity due to the increased expression of the elements of the respiratory chain and oxidative phosphorylation, both at the mRNA and protein level. The respiratory burst potentiated the production of reactive oxygen species but was not associated to increased levels of ATP, leading to the conclusion that the energy was readily spent in the adaptive response to the electromagnetic field. Taken together, our data demonstrate that, regardless of individual molecular defects, it is possible to control cancer cells with a specific irradiation that imposes a mitochondrial metabolic switch, regulating calcium fluxes and deleterious to cancer growth. This approach lays the foundations for a personalized cancer medicine.