Clinical Relevance of Cherry Angiomas. / Relevancia clínica de los angiomas en cereza.

Cherry angiomas are the most common vascular tumors of the skin. They are particularly prevalent in the general population and become more common with age. Although an association with cancer was suggested at the end of the 19th century, when these tumors were first described, it could not be demonstrated. For many decades, therefore, cherry angiomas were considered to have no clinical relevance other than their association with age. A number of studies in recent years, however, have shown a link between cherry angiomas and exposure to various toxic substances and medications, benign and malignant diseases, and immunosuppression, rekindling interest in these lesions and providing clues for a better understanding of their etiology, pathophysiology, and clinical relevance.

Risk factors for the development of a second melanoma in patients with cutaneous melanoma.

BACKGROUND: Cutaneous melanoma patients have an increased risk of developing other neoplasms, especially cutaneous neoplasms and other melanomas. Identifying factors associated with an increased risk might be useful in the development of melanoma guidelines. OBJECTIVES: To identify risk factors related to the development of a second primary melanoma in a series of patients diagnosed with sporadic melanoma and to establish the estimated incidence rate. METHODS: A longitudinal study based on prospective follow-up information of patients diagnosed with sporadic cutaneous melanoma at our centre from 2000 to 2015 was performed. Cumulative incidence was estimated based on competing risk models, and the association of characteristics with the risk of a second melanoma was performed by Cox proportional hazard models. RESULTS: Out of 1447 patients included in the study, after a median follow-up of 61 months, 55 patients (3.8%) developed a second melanoma. Fair hair colour, more than 100 common melanocytic nevi and the presence of more than 50 cherry angiomas were independently associated with the development of a second melanoma. The site and the histological subtype of the first and second melanomas were not consistent. The second melanomas were thinner than the first ones. CONCLUSIONS: Fair-haired and multiple-nevi patients might benefit from more intensive prevention measures. The finding of cherry angiomas as a risk factor suggests that these lesions could be markers of skin sun damage in the setting of certain degree of genetic susceptibility.

[Anogenital warts: a clinical, pathological and virological study]. / Verrugas anogenitales: estudio clínico-patológico y virológico.

The objective of this study was to investigate the possible relationship between the presence of anogenital warts (AGW) in children and the sexual abuse as mode of transmission. Our series includes 8 patients with AGW who were treated in our hospital during the year 2007. A complete physical examination was carried out, including colposcopy or anoscopy, and samples were taken for histopathological examination and human papiloma virus (HPV) subtyping. We considered perinatal transmission as a possible route in two cases. Although sexual abuse was definitively confirmed in only one case, we observed some findings in four cases that led us to consider the possibility of sexual abuse. We did not consider the possibility of heteroinoculation or autoinoculation from common warts in any case. Our results have demonstrated the difficulty in assessing with certainty the source of HPV contamination in children with AGW.

Relevancia clínica de los angiomas en cereza / Clinical Relevance of Cherry Angiomas

Los angiomas en cereza son los tumores vasculares cutáneos más frecuentes. Son muy prevalentes en la población general y esta prevalencia aumenta con la edad. Aunque, en sus primeras descripciones en la literatura, a finales del siglo XIX, se relacionaron con el cáncer, dicha asociación no pudo demostrarse posteriormente por lo que, durante muchas décadas, se han considerado unas lesiones asociadas al proceso del envejecimiento sin otro significado clínico particular. Sin embargo, en los últimos años, han sido objeto de un mayor interés al ser publicados algunos estudios que muestran una asociación con la exposición a diversos tóxicos y fármacos, enfermedades malignas y no malignas y la inmunosupresión que pueden ayudar a conocer mejor su etiopatogenia y su relevancia clínica (AU)

Cherry angiomas are the most common vascular tumors of the skin. They are particularly prevalent in the general population and become more common with age. Although an association with cancer was suggested at the end of the 19th century, when these tumors were first described, it could not be demonstrated. For many decades, therefore, cherry angiomas were considered to have no clinical relevance other than their association with age. A number of studies in recent years, however, have shown a link between cherry angiomas and exposure to various toxic substances and medications, benign and malignant diseases, and immunosuppression, rekindling interest in these lesions and providing clues for a better understanding of their etiology, pathophysiology, and clinical relevance (AU)

[Translated article] Clinical Relevance of Cherry Angiomas / Relevancia clínica de los angiomas en cereza

Cherry angiomas are the most common vascular tumors of the skin. They are particularly prevalent in the general population and become more common with age. Although an association with cancer was suggested at the end of the 19th century, when these tumors were first described, it could not be demonstrated. For many decades, therefore, cherry angiomas were considered to have no clinical relevance other than their association with age. A number of studies in recent years, however, have shown a link between cherry angiomas and exposure to various toxic substances and medications, benign and malignant diseases, and immunosuppression, rekindling interest in these lesions and providing clues for a better understanding of their etiology, pathophysiology, and clinical relevance (AU)

Los angiomas en cereza son los tumores vasculares cutáneos más frecuentes. Son muy prevalentes en la población general y esta prevalencia aumenta con la edad. Aunque, en sus primeras descripciones en la literatura, a finales del siglo XIX, se relacionaron con el cáncer, dicha asociación no pudo demostrarse posteriormente por lo que, durante muchas décadas, se han considerado unas lesiones asociadas al proceso del envejecimiento sin otro significado clínico particular. Sin embargo, en los últimos años, han sido objeto de un mayor interés al ser publicados algunos estudios que muestran una asociación con la exposición a diversos tóxicos y fármacos, enfermedades malignas y no malignas y la inmunosupresión que pueden ayudar a conocer mejor su etiopatogenia y su relevancia clínica (AU)

Verrugas anogenitales: estudio clínico-patológico y virológico / Anogenital warts: a clinical, pathological and virological study

El objetivo de este estudio es investigar la posible relación entre la presencia de verrugas ano genitales (VAG) durante la edad pediátrica y la posibilidad del abuso sexual como modo de transmisión. Referimos nuestra experiencia con 8 niños con VAG tratados en nuestro departamento durante el año 2007. En todos los pacientes se efectuaron una detallada anamnesis y exploración física. Las exploraciones complementarias incluyeron una colposcopia o rectoscopia, examen anatomopatológico y tipificación del serotipo del virus del papiloma humano (VPH).Consideramos la transmisión perinatal como posible fuente de transmisión en dos casos. Tan sólo pudo confirmarse de manera definitiva el abuso sexual como fuente de contagio en un caso, en cuatro de los casos restantes encontramos algún hallazgo que nos hizo sospechar la posibilidad de esta vía de transmisión. No se consideró la posibilidad de autoinoculación o heteroinoculacióna partir de verrugas cutáneas en ningún caso. Nuestros resultados ponen de manifiesto la dificultad de asegurar con certeza el modo de transmisión de las VAG en la edad pediátrica (AU)

The objective of this study was to investigate the possible relationship between the presence of ano genital warts (AGW) in children and the sexual abuse as mode of transmission. Our series includes 8 patients with AGW who were treated in our hospital during the year 2007. A complete physical examination was carried out, including colposcopy or anoscopy, and samples were taken for histopathological examination and human papilomavirus (HPV) subtyping. We considered perinatal transmission as a possible route in two cases. Although sexual abuse was definitively confirmed in only one case, we observed some findings in four cases that led us to consider the possibility of sexual abuse. We did not consider the possibility of heteroinoculation or autoinoculation from common warts in any case. Our results have demonstrated the difficulty in assessing with certainty the source of HPV contamination in children with AGW (AU)