Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros

Banco de datos
Tipo del documento
Asunto de la revista
País de afiliación
Intervalo de año de publicación
1.
Immunity ; 45(4): 889-902, 2016 10 18.
Artículo en Inglés | MEDLINE | ID: mdl-27692609

RESUMEN

In recent years, various intervention strategies have reduced malaria morbidity and mortality, but further improvements probably depend upon development of a broadly protective vaccine. To better understand immune requirement for protection, we examined liver-stage immunity after vaccination with irradiated sporozoites, an effective though logistically difficult vaccine. We identified a population of memory CD8+ T cells that expressed the gene signature of tissue-resident memory T (Trm) cells and remained permanently within the liver, where they patrolled the sinusoids. Exploring the requirements for liver Trm cell induction, we showed that by combining dendritic cell-targeted priming with liver inflammation and antigen recognition on hepatocytes, high frequencies of Trm cells could be induced and these cells were essential for protection against malaria sporozoite challenge. Our study highlights the immune potential of liver Trm cells and provides approaches for their selective transfer, expansion, or depletion, which may be harnessed to control liver infections or autoimmunity.


Asunto(s)
Linfocitos T CD8-positivos/inmunología , Memoria Inmunológica/inmunología , Hígado/inmunología , Malaria/inmunología , Animales , Linfocitos T CD8-positivos/parasitología , Culicidae , Células Dendríticas/inmunología , Células Dendríticas/parasitología , Hepatocitos/inmunología , Hepatocitos/parasitología , Hígado/parasitología , Hepatopatías/inmunología , Hepatopatías/parasitología , Vacunas contra la Malaria/inmunología , Ratones , Plasmodium berghei/inmunología , Esporozoítos/inmunología , Esporozoítos/parasitología , Vacunación/métodos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA