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1.

Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): a randomised, double-blind, placebo-controlled, phase 3 trial.

Erba, Harry P; Montesinos, Pau; Kim, Hee-Je; Patkowska, Elzbieta; Vrhovac, Radovan; Zák, Pavel; Wang, Po-Nan; Mitov, Tsvetomir; Hanyok, James; Kamel, Yasser Mostafa; Rohrbach, Jaime E Connolly; Liu, Li; Benzohra, Aziz; Lesegretain, Arnaud; Cortes, Jorge; Perl, Alexander E; Sekeres, Mikkael A; Dombret, Hervé; Amadori, Sergio; Wang, Jianxiang; Levis, Mark J; Schlenk, Richard F.

Lancet ; 401(10388): 1571-1583, 2023 05 13.

Artículo en Inglés | MEDLINE | ID: mdl-37116523

2.

Follow-up of patients with R/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial.

Perl, Alexander E; Larson, Richard A; Podoltsev, Nikolai A; Strickland, Stephen; Wang, Eunice S; Atallah, Ehab; Schiller, Gary J; Martinelli, Giovanni; Neubauer, Andreas; Sierra, Jorge; Montesinos, Pau; Récher, Christian; Yoon, Sung-Soo; Hosono, Naoko; Onozawa, Masahiro; Chiba, Shigeru; Kim, Hee-Je; Hasabou, Nahla; Lu, Qiaoyang; Tiu, Ramon; Levis, Mark J.

Blood ; 139(23): 3366-3375, 2022 06 09.

Artículo en Inglés | MEDLINE | ID: mdl-35081255

3.

Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia.

Connor, Matthew P; Prathapa, Neeharika; Frey, Noelle V; Gill, Saar I; Hexner, Elizabeth O; Bruno, Ximena Jordan; Lai, Catherine E; Loren, Alison W; Luger, Selina M; Matthews, Andrew H; McCurdy, Shannon R; Perl, Alexander E; Porter, David L; Zeringue, Arlene; Oved, Joseph H; Olson, Timothy S; Pratz, Keith W; Babushok, Daria V.

Haematologica ; 2024 Apr 18.

Artículo en Inglés | MEDLINE | ID: mdl-38634143

4.

Clinical outcomes of hypomethylating agents plus Venetoclax as frontline treatment in patients 75 years and older with acute myeloid leukemia: Real-world data from eight US academic centers.

Abaza, Yasmin; Winer, Eric S; Murthy, Guru Subramanian Guru; Shallis, Rory M; Matthews, Andrew H; Badar, Talha; Geramita, Emily M; Kota, Vamsi K; Swaroop, Alok; Doukas, Peter; Bradshaw, Danielle; Helenowski, Irene B; Liu, Yingzhe; Zhang, Hui; Im, Annie; Litzow, Mark R; Perl, Alexander E; Atallah, Ehab; Altman, Jessica K.

Am J Hematol ; 99(4): 606-614, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38342997

5.

Real-world effectiveness of intensive chemotherapy with 7&3 versus venetoclax and hypomethylating agent in acute myeloid leukemia.

Matthews, Andrew H; Perl, Alexander E; Luger, Selina M; Gill, Saar I; Lai, Catherine; Porter, David L; Skuli, Sarah; Bruno, Ximena Jordan; Carroll, Martin P; Freyer, Craig W; Carulli, Alison; Babushok, Daria V; Frey, Noelle V; Hexner, Elizabeth O; Martin, Mary Ellen; McCurdy, Shannon R; Stadtmauer, Edward A; Loren, Alison W; Paralkar, Vikram R; Maillard, Ivan P; Pratz, Keith W.

Am J Hematol ; 98(8): 1254-1264, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37334852

6.

Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML.

Perl, Alexander E; Martinelli, Giovanni; Cortes, Jorge E; Neubauer, Andreas; Berman, Ellin; Paolini, Stefania; Montesinos, Pau; Baer, Maria R; Larson, Richard A; Ustun, Celalettin; Fabbiano, Francesco; Erba, Harry P; Di Stasi, Antonio; Stuart, Robert; Olin, Rebecca; Kasner, Margaret; Ciceri, Fabio; Chou, Wen-Chien; Podoltsev, Nikolai; Recher, Christian; Yokoyama, Hisayuki; Hosono, Naoko; Yoon, Sung-Soo; Lee, Je-Hwan; Pardee, Timothy; Fathi, Amir T; Liu, Chaofeng; Hasabou, Nahla; Liu, Xuan; Bahceci, Erkut; Levis, Mark J.

N Engl J Med ; 381(18): 1728-1740, 2019 10 31.

Artículo en Inglés | MEDLINE | ID: mdl-31665578

7.

Characteristics and outcome of patients with core-binding factor acute myeloid leukemia and FLT3-ITD: results from an international collaborative study.

Kayser, Sabine; Kramer, Michael; Martínez-Cuadrón, David; Grenet, Justin; Metzeler, Klaus H; Sustkova, Zuzana; Luskin, Marlise R; Brunner, Andrew M; Elliott, Michelle A; Gil, Cristina; Marini, Sandra Casal; Rácil, Zdenek; Cetkovsky, Petr; Novak, Jan; Perl, Alexander E; Platzbecker, Uwe; Stölzel, Friedrich; Ho, Anthony D; Thiede, Christian; Stone, Richard M; Röllig, Christoph; Montesinos, Pau; Schlenk, Richard F; Levis, Mark J.

Haematologica ; 107(4): 836-843, 2022 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-34348451

8.

Gilteritinib clinical activity in relapsed/refractory FLT3 mutated acute myeloid leukemia previously treated with FLT3 inhibitors.

Numan, Yazan; Abdel Rahman, Zaid; Grenet, Justin; Boisclair, Stephanie; Bewersdorf, Jan Philipp; Collins, Cailin; Barth, Dylan; Fraga, Martina; Bixby, Dale L; Zeidan, Amer M; Yilmaz, Musa; Desai, Pankil; Mannis, Gabriel; Deutsch, Yehuda E; Abaza, Yasmin; Dinner, Shira; Frankfurt, Olga; Litzow, Mark; Al-Kali, Aref; Foran, James M; Sproat, Lisa Z; Jovanovic, Borko; Daver, Naval; Perl, Alexander E; Altman, Jessica K.

Am J Hematol ; 97(3): 322-328, 2022 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-34981560

9.

Day 4 vs. day 12 G-CSF administration following reduced intensity peripheral blood allogeneic stem cell transplant.

Hatch, Rachel V; Freyer, Craig W; Carulli, Alison; Redline, Gretchen; Babushok, Daria V; Frey, Noelle V; Gill, Saar I; Hexner, Elizabeth O; Luger, Selina M; Martin, Mary Ellen; McCurdy, Shannon R; Perl, Alexander E; Porter, David L; Pratz, Keith W; Stadtmauer, Edward A; Loren, Alison W.

J Oncol Pharm Pract ; 28(4): 892-897, 2022 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-35191732

10.

Availability of FLT3 inhibitors: how do we use them?

Perl, Alexander E.

Blood ; 134(9): 741-745, 2019 08 29.

Artículo en Inglés | MEDLINE | ID: mdl-31243041

11.

Phase 2b study of 2 dosing regimens of quizartinib monotherapy in FLT3-ITD-mutated, relapsed or refractory AML.

Cortes, Jorge E; Tallman, Martin S; Schiller, Gary J; Trone, Denise; Gammon, Guy; Goldberg, Stuart L; Perl, Alexander E; Marie, Jean-Pierre; Martinelli, Giovanni; Kantarjian, Hagop M; Levis, Mark J.

Blood ; 132(6): 598-607, 2018 08 09.

Artículo en Inglés | MEDLINE | ID: mdl-29875101

12.

Allogeneic hematopoietic cell transplantation improves outcome of adults with t(6;9) acute myeloid leukemia: results from an international collaborative study.

Kayser, Sabine; Hills, Robert K; Luskin, Marlise R; Brunner, Andrew M; Terré, Christine; Westermann, Jörg; Menghrajani, Kamal; Shaw, Carole; Baer, Maria R; Elliott, Michelle A; Perl, Alexander E; Rácil, Zdenek; Mayer, Jiri; Zak, Pavel; Szotkowski, Tomas; de Botton, Stéphane; Grimwade, David; Mayer, Karin; Walter, Roland B; Krämer, Alwin; Burnett, Alan K; Ho, Anthony D; Platzbecker, Uwe; Thiede, Christian; Ehninger, Gerhard; Stone, Richard M; Röllig, Christoph; Tallman, Martin S; Estey, Elihu H; Müller-Tidow, Carsten; Russell, Nigel H; Schlenk, Richard F; Levis, Mark J.

Haematologica ; 105(1): 161-169, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31004014

13.

Risk of invasive fungal infections in patients with high-risk MDS and AML receiving hypomethylating agents.

Kim, Gee Youn Geeny; Burns, Jonathan; Freyer, Craig W; Hamilton, Keith W; Frey, Noelle V; Gill, Saar I; Hexner, Elizabeth O; Luger, Selina M; Mangan, James K; Martin, Mary E; McCurdy, Shannon R; Perl, Alexander E; Porter, David L; Schuster, Mindy G; Stadtmauer, Edward A; Loren, Alison W.

Am J Hematol ; 95(7): 792-798, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32242967

14.

Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial.

Cortes, Jorge E; Khaled, Samer; Martinelli, Giovanni; Perl, Alexander E; Ganguly, Siddhartha; Russell, Nigel; Krämer, Alwin; Dombret, Hervé; Hogge, Donna; Jonas, Brian A; Leung, Anskar Yu-Hung; Mehta, Priyanka; Montesinos, Pau; Radsak, Markus; Sica, Simona; Arunachalam, Meena; Holmes, Melissa; Kobayashi, Ken; Namuyinga, Ruth; Ge, Nanxiang; Yver, Antoine; Zhang, Yufen; Levis, Mark J.

Lancet Oncol ; 20(7): 984-997, 2019 07.

Artículo en Inglés | MEDLINE | ID: mdl-31175001

15.

Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis.

Smith, Catherine C; Paguirigan, Amy; Jeschke, Grace R; Lin, Kimberly C; Massi, Evan; Tarver, Theodore; Chin, Chen-Shan; Asthana, Saurabh; Olshen, Adam; Travers, Kevin J; Wang, Susana; Levis, Mark J; Perl, Alexander E; Radich, Jerald P; Shah, Neil P.

Blood ; 130(1): 48-58, 2017 07 06.

Artículo en Inglés | MEDLINE | ID: mdl-28490572

16.

Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia.

Tasian, Sarah K; Teachey, David T; Li, Yong; Shen, Feng; Harvey, Richard C; Chen, I-Ming; Ryan, Theresa; Vincent, Tiffaney L; Willman, Cheryl L; Perl, Alexander E; Hunger, Stephen P; Loh, Mignon L; Carroll, Martin; Grupp, Stephan A.

Blood ; 129(2): 177-187, 2017 01 12.

Artículo en Inglés | MEDLINE | ID: mdl-27777238

17.

The most novel of the novel agents for acute myeloid leukemia.

Perl, Alexander E.

Curr Opin Hematol ; 25(2): 81-89, 2018 03.

Artículo en Inglés | MEDLINE | ID: mdl-29278535

18.

Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial.

Cortes, Jorge; Perl, Alexander E; Döhner, Hartmut; Kantarjian, Hagop; Martinelli, Giovanni; Kovacsovics, Tibor; Rousselot, Philippe; Steffen, Björn; Dombret, Hervé; Estey, Elihu; Strickland, Stephen; Altman, Jessica K; Baldus, Claudia D; Burnett, Alan; Krämer, Alwin; Russell, Nigel; Shah, Neil P; Smith, Catherine C; Wang, Eunice S; Ifrah, Norbert; Gammon, Guy; Trone, Denise; Lazzaretto, Deborah; Levis, Mark.

Lancet Oncol ; 19(7): 889-903, 2018 07.

Artículo en Inglés | MEDLINE | ID: mdl-29859851

19.

Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition.

Kasner, Margaret T; Mick, Rosemarie; Jeschke, Grace R; Carabasi, Matthew; Filicko-O'Hara, Joanne; Flomenberg, Neal; Frey, Noelle V; Hexner, Elizabeth O; Luger, Selina M; Loren, Alison W; Mangan, James K; Wagner, John L; Weiss, Mark; Carroll, Martin; Perl, Alexander E.

Invest New Drugs ; 36(4): 657-666, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-29607465

20.

The FLT3^N701K mutation causes clinical AML resistance to gilteritinib and triggers TKI sensitivity switch to quizartinib.

Joshi, Sunil K; Pittsenbarger, Janét; Kennedy, Vanessa E; Peretz, Cheryl A C; Perl, Alexander E; Smith, Catherine C; Tyner, Jeffrey W; Druker, Brian J; Traer, Elie.

Am J Hematol ; 98(12): E364-E368, 2023 12.

Artículo en Inglés | MEDLINE | ID: mdl-37815132

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