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1.
Phys Rev E Stat Nonlin Soft Matter Phys ; 72(5 Pt 1): 051912, 2005 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-16383650

RESUMEN

We address the question of the ventricles' dilation as a possible instability of the intracranial dynamics. The ventricular system is shown to be governed by a dynamical equation derived from first principles. This general nonlinear scheme is linearized around a well-defined steady state which is mapped onto a pressure-volume model with an algebraic effective compliance depending on the ventricles' geometry, the ependyma's elasticity, and the cerebrospinal fluid (CSF) surface tension. Instabilities of different natures are then evidenced. A first type of structural instability results from the compelling effects of the CSF surface tension and the elastic properties of the ependyma. A second type of dynamical instability occurs for low enough values of the aqueduct's conductance. This last case is then shown to be accompanied by a spontaneous ventricle's dilation. A strong correlation with some active hydrocephalus is evidenced and discussed. The transfer function of the ventricles, compared to a low-pass filter, are calculated in both the stable and unstable regimes and appear to be very different.


Asunto(s)
Relojes Biológicos , Ventrículos Cerebrales/fisiopatología , Dilatación Patológica/fisiopatología , Hidrocefalia/fisiopatología , Presión Intracraneal , Modelos Biológicos , Animales , Líquido Cefalorraquídeo , Simulación por Computador , Elasticidad , Humanos , Presión
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