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1.
Actas Dermosifiliogr ; 114(1): 49-53, 2023 Jan.
Artículo en Inglés, Español | MEDLINE | ID: mdl-35963337

RESUMEN

Immunosuppressants and immunomodulators are widely used in dermatology. Some of these drugs, however, can increase the risk of severe COVID-19. New antivirals against SARS-CoV-2 have been shown to reduce progression to COVID-19 pneumonia in susceptible patients, but their availability is limited. On May 23, 2022, the Spanish Agency for Medicines and Medical Devices (AEMPS) updated its priority eligibility criteria for SARS-CoV-2 antiviral therapy. In this practical guide, we review the indications for these new drugs and provide guidance on which patients with mild to moderate COVID might benefit from their use in dermatology.


Asunto(s)
COVID-19 , Dermatología , Humanos , SARS-CoV-2 , Inmunosupresores/efectos adversos , Susceptibilidad a Enfermedades/inducido químicamente , Antivirales/uso terapéutico
2.
Oncologist ; 25(8): 669-679, 2020 08.
Artículo en Inglés | MEDLINE | ID: mdl-31943525

RESUMEN

INTRODUCTION: Immune-related adverse event (IRAE) onset may represent a clinical biomarker for anti-programmed cell death protein 1 (PD-1) antibody response based on emerging evidence from patients with various advanced malignancies. This phenomenon has not been previously reported in a multidisease cohort of patients with gastrointestinal (GI) cancer with Food and Drug Administration (FDA)-approved indications to receive immune checkpoint inhibitor therapy. MATERIALS AND METHODS: The study was a multicenter retrospective cohort analysis of 76 patients with GI cancer who had received anti-PD-1 antibodies for FDA-approved indications. The primary and secondary outcomes of the study were progression-free survival (PFS) and overall survival (OS) in patients based upon IRAE presence, respectively. PFS and OS were estimated by the Kaplan-Meier method; a Cox proportional-hazards model adjusted for IRAE onset, patient age, and enrolling institution was used to analyze outcomes. RESULTS: Median PFS and OS were prolonged in patients who experienced IRAEs compared with those who did not experience them (PFS: not reached [NR] vs. 3.9 months [hazard ratio (HR) 0.13, 95% confidence interval (CI) 0.05-0.3, p < .001]; OS: NR vs. 7.4 months [HR 0.11, 95% CI 0.03-0.36, p < .001]). Among patients who experienced IRAEs, there were no significant differences in PFS and OS by either initial IRAE severity, management, or time to onset. CONCLUSION: Patients with gastrointestinal cancer who experienced IRAEs while on anti-PD-1 antibodies demonstrated significant improvements in PFS and OS compared with their counterparts who did not develop IRAEs. Although these findings add to results from studies in other tumor types, larger prospective studies are needed prior to clinical adoption of IRAE onset as a biomarker for immune checkpoint inhibitor response. IMPLICATIONS FOR PRACTICE: Predictive clinical biomarkers for immune checkpoint inhibitor response have been understudied in the field of immuno-oncology. Immune-related adverse event onset appears to be one such biomarker. Across tumor types, immune-related adverse event onset has been associated with response to anti-programmed cell death protein 1 (PD-1) antibodies. The results of this study demonstrate this for the first time in patients with gastrointestinal cancer receiving anti-PD-1 antibodies. Before immune-related adverse event onset can be adopted clinically as a predictive biomarker for immune checkpoint inhibitor response, however, larger prospective studies are needed to better understand the nuances between immune-related adverse event characteristics (severity, site, management, timing of onset) and immune checkpoint inhibitor effectiveness.


Asunto(s)
Neoplasias Gastrointestinales , Inhibidores de Puntos de Control Inmunológico , Neoplasias Gastrointestinales/tratamiento farmacológico , Humanos , Inmunoterapia/efectos adversos , Estudios Prospectivos , Estudios Retrospectivos , Estados Unidos , United States Food and Drug Administration
5.
J Osteoporos ; 2020: 8208397, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33014327

RESUMEN

PURPOSE: To describe the implementation of a postfracture care program in a private hospital in Colombia, the results achieved after the program's first year, and the challenges encountered. METHODS: A cross-sectional descriptive study of the first year's outcomes. The program was implemented following best practices described in the "Capture the Fracture" framework. We assessed the management of fractures before the launch of the program. A multidisciplinary group was established to collaborate on the diagnosis and treatment of patients with osteoporotic fractures. A full-time program coordinator was appointed. We analyzed the program's clinical outcomes and limitations. RESULTS: One-hundred and ninety patients were included in the study, with an average age of 76.7. Hip fracture was the most frequent one (33.6%). After the first year of implementing the program, 39.4% of patients received osteoporosis treatment, with an adherence rate of 73%. The incidence of subsequent falls was 5.8% and 1% for new fractures. CONCLUSIONS: The implementation of a program for patients' care with fragility fractures is challenging for healthcare institutions. The role of a full-time coordinator is critical for the proper operation of such programs.

6.
Rev Argent Microbiol ; 40(4): 211-7, 2008.
Artículo en Español | MEDLINE | ID: mdl-19213243

RESUMEN

In order to estimate the frequence of Candida dubliniensis in clinical samples in F. J. Muñiz Infectious Diseases Hospital, a total of 388 yeasts from September 2005 to August 2007. There were 212 isolates which presented a green color on CHROMagar Candida medium and produced germ tubes and chlamidoconidiae in milk-agar; so as to distinguish whether they corresponded to Candida albicans or C. dubliniensis, different phenotypical methods were utilized. It was also evaluated the usefulness of each one in order to suggest a simple, economic and reliable identification algorithm. Each isolate was subcultured in two chromogenic media and then, the following determinations were done: chlamidospores production in Staib-agar, tomato-carrot-agar and tobacco-agar, colonies macromorphology was also studied in the last medium; opacity-test in Tween 80-CaCl2 agar (lipase activity), growing capacity at 45 degrees C, and D-xylose assimilation. Thirteen strains (6.1%) corresponded to C. dubliniensis. The difference in color between both species on chromogenic media was not so stressed as it is pointed out in some works. The more specific and sensitive tests were the ability to grow at 45 degrees C, D-xylose assimilation, color and macroscopic appearance in tobacco-agar. Between 11.6% and 15.1% of C. albicans strains produced chlamidoconidiae in the 3 differential media tested. The opacity halo (lipase) was evident in 95.6% of C. albicans isolates but 2 out of 13 C. dubliniensis also presented precipitation halo. We consider that at least 3 different phenotypical methods should be used to distinguish properly these two species since none of the tests is absolutely sensitive or specific.


Asunto(s)
Candida/aislamiento & purificación , Candidiasis/microbiología , Candida/clasificación , Candida/crecimiento & desarrollo , Candida/metabolismo , Candida albicans , Compuestos Cromogénicos/metabolismo , Medios de Cultivo/farmacología , Femenino , Humanos , Masculino , Micología/métodos , Fenotipo , Especificidad de la Especie , Xilosa/metabolismo
7.
Actas dermo-sifiliogr. (Ed. impr.) ; 114(1): 49-53, jan. 2023. tab, ilus
Artículo en Español | IBECS (España) | ID: ibc-214476

RESUMEN

En dermatología es frecuente el uso de inmunosupresores e inmunomoduladores, algunos de los cuales pueden predisponer al desarrollo de enfermedad grave por SARS-CoV-2. Las nuevas terapias antivirales frente al SARS-CoV-2 han demostrado reducir la progresión a neumonía por COVID-19 grave en pacientes susceptibles. El pasado 23 de mayo, la Agencia Española de Medicamentos y Productos Sanitarios publicó la última actualización sobre los criterios para la priorización en el acceso precoz a estos fármacos debido a su limitada disponibilidad. En esta guía práctica revisamos los pacientes dermatológicos que en caso de contraer COVID-19 leve-moderada pueden beneficiarse de los nuevos antivirales, así como su indicación (AU)


Immunosuppressants and immunomodulators are widely used in dermatology. Some of these drugs, however, can increase the risk of severe COVID-19. New antivirals against SARS-CoV-2 have been shown to reduce progression to COVID-19 pneumonia in susceptible patients, but their availability is limited. On May 23, 2022, the Spanish Agency for Medicines and Medical Devices (AEMPS) updated its priority eligibility criteria for SARS-CoV-2 antiviral therapy. In this practical guide, we review the indications for these new drugs and provide guidance on which patients with mild to moderate COVID might benefit from their use in dermatology (AU)


Asunto(s)
Humanos , Antivirales/uso terapéutico , Infecciones por Coronavirus/tratamiento farmacológico , Infecciones por Coronavirus/inmunología , Inmunosupresores/efectos adversos , Enfermedades de la Piel/tratamiento farmacológico , Factores Inmunológicos/efectos adversos , Susceptibilidad a Enfermedades/inducido químicamente , Inmunomodulación
8.
Actas dermo-sifiliogr. (Ed. impr.) ; 114(1): T49-T53, jan. 2023. ilus, tab
Artículo en Inglés | IBECS (España) | ID: ibc-214477

RESUMEN

Immunosuppressants and immunomodulators are widely used in dermatology. Some of these drugs, however, can increase the risk of severe COVID-19. New antivirals against SARS-CoV-2 have been shown to reduce progression to COVID-19 pneumonia in susceptible patients, but their availability is limited. On May 23, 2022, the Spanish Agency for Medicines and Medical Devices (AEMPS) updated its priority eligibility criteria for SARS-CoV-2 antiviral therapy. In this practical guide, we review the indications for these new drugs and provide guidance on which patients with mild to moderate COVID might benefit from their use in dermatology (AU)


En dermatología es frecuente el uso de inmunosupresores e inmunomoduladores, algunos de los cuales pueden predisponer al desarrollo de enfermedad grave por SARS-CoV-2. Las nuevas terapias antivirales frente al SARS-CoV-2 han demostrado reducir la progresión a neumonía por COVID-19 grave en pacientes susceptibles. El pasado 23 de mayo, la Agencia Española de Medicamentos y Productos Sanitarios publicó la última actualización sobre los criterios para la priorización en el acceso precoz a estos fármacos debido a su limitada disponibilidad. En esta guía práctica revisamos los pacientes dermatológicos que en caso de contraer COVID-19 leve-moderada pueden beneficiarse de los nuevos antivirales, así como su indicación (AU)


Asunto(s)
Humanos , Antivirales/uso terapéutico , Infecciones por Coronavirus/tratamiento farmacológico , Infecciones por Coronavirus/inmunología , Inmunosupresores/efectos adversos , Enfermedades de la Piel/tratamiento farmacológico , Factores Inmunológicos/efectos adversos , Susceptibilidad a Enfermedades/inducido químicamente , Inmunomodulación
10.
Rev Salud Publica (Bogota) ; 7(3): 339-48, 2005.
Artículo en Español | MEDLINE | ID: mdl-16396422

RESUMEN

OBJECTIVE: Obtaining information about the perceptions, attitudes and practices which people living in the Colombian Amazon region hold about the aetiology of malaria, its diagnosis, prophylaxis, therapy, prevention and their perception concerning the risk of contracting malaria. METHODS: A qualitative study was carried out; focal groups were used as the research technique. A total of 23 were held, each one involving 6 to 10 people classified according to some inclusion variables which were pertinent for the study. RESULTS: The study revealed that the people having the best knowledge of preventative and control measures were those having a high risk of acquiring malaria; however, they did not put them into practice. There are difficulties in gaining access to diagnosis and treatment of malaria and problems of self-medication in high risk populations. CONCLUSIONS: The behavioural factors of those populations exposed to malaria could facilitate and/or hamper control interventions in Colombia's Amazonas Department.


Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Malaria , Colombia , Femenino , Humanos , Malaria/prevención & control , Masculino
11.
Rev. neuro-psiquiatr. (Impr.) ; 83(3): 203-207, jul-sep 2020. graf
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1150079

RESUMEN

Resumen El sarcoma fibromixoide de bajo grado (LGFMS) es un tumor de tejidos blandos de origen mesenquimal. Los sarcomas son un grupo heterogéneo, que representa el 1% de todas las neoplasias. Los sarcomas primarios del sistema nervioso central (SNC) son raros y representan solo el 0,7% del total de sarcomas, con una incidencia estimada de 3 por cada 10 millones de personas por año. En este artículo, se describe el caso de una mujer de 59 años que presentó un sarcoma fibromixoide intracraneal de bajo grado, localizado en la región parietal derecha. Se discute el curso clínico, estudios de imágenes, características histopatológicas y tratamiento de este diagnóstico infrecuente y, por lo mismo, muy poco reportado. El diagnóstico definitivo se obtiene, ciertamente, mediante estudios histo-patológicos.


Summary Low-grade fibromyxoid sarcoma (LGFMS) is a soft tissue tumor of mesenchymal origin. Sarcomas are a heterogeneous group, representing 1% of all neoplasm diagnoses. Primary sarcomas of the central nervous system (CNS) are rare, and represent only 0.7% of all sarcomas, with an estimated incidence of 3 per 10 million people per year. The case of a 59-year-old woman who developed a low-grade intracranial fibromyxoid sarcoma in the right parietal region, is described. The clinical course, imaging studies, histopathological features, and treatment approach of this unusual diagnosis, are discussed. Low-grade intracranial fibromyxoid sarcoma is a rare and probably under- reported condition. The definitive diagnosis is usually made through histo-pathological studies.

12.
Arch Neurol ; 32(11): 727-30, 1975 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-1180741

RESUMEN

The clinical spectrum of juvenile head trauma syndromes was derived from an analysis of 50 attacks in 25 patients. Attacks were grouped into four clinical types: (1) hemiparesis; (2) somnolence, irritability, and vomiting; (3) blindness; and (4) brain stem signs. Our evidence shows that these four types are different manifestations of a common underlying process. All attacks followed mild head trauma after a latent interval, generally of one to ten minutes. Forty of the 50 attacks occurred in patients under 14 years of age. Full recovery occurred after a variable time in all but one instance. This patient, and one other, had an angiographically demonstrable occlusion of a branch of the middle cerebral artery. In clinical and laboratory features, these attacks resemble classical migraine and presumably have a similar underlying mechanism.


Asunto(s)
Lesiones Encefálicas/diagnóstico , Trastornos Migrañosos/diagnóstico , Adolescente , Adulto , Lesiones Encefálicas/complicaciones , Tronco Encefálico , Niño , Preescolar , Diagnóstico Diferencial , Femenino , Hemiplejía/etiología , Humanos , Masculino , Trastornos Migrañosos/etiología , Síndrome , Inconsciencia/etiología , Vómitos/etiología
13.
Biochem Pharmacol ; 58(7): 1209-19, 1999 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-10484079

RESUMEN

Male Hartley guinea pigs were fed a hypercholesterolemic diet rich in lauric and myristic acids with 0, 10, or 20 mg/kg of simvastatin or atorvastatin for 21 days. Atorvastatin and simvastatin resulted in a lowering of plasma low-density lipoprotein (LDL) cholesterol in a dose-dependent manner by an average of 48 and 61% with 10 and 20 mg/kg, respectively. Both statins were equally effective in lowering plasma LDL cholesterol and apolipoprotein B (apo-B) levels. Atorvastatin and simvastatin treatments yielded LDL particles that differed in composition from the control. Due to the relevance of LDL oxidation and cholesteryl ester transfer in plasma to the progression of atherosclerosis, these parameters were analyzed after statin treatment. Atorvastatin and simvastatin treatment decreased the susceptibility of LDL particles to oxidation by 95% as determined by the formation of thiobarbituric acid reactive substances. An 80% decrease in the transfer of cholesteryl ester between high-density lipoprotein (HDL) and the apo-B-containing lipoproteins was observed after simvastatin and atorvastatin treatment. In addition, statin effects on plasma LDL transport were studied. Simvastatin- and atorvastatin-treated guinea pigs exhibited 125 and 175% faster LDL fractional catabolic rates, respectively, compared with control animals. No change in LDL apo-B flux was induced by either treatment; however, LDL apo-B pool size was reduced after statin treatment. Hepatic microsomal free cholesterol was lower in the atorvastatin and simvastatin groups. However, only atorvastatin treatment resulted in an 80% decrease of acyl-CoA:cholesterol acyltransferase activity (P < 0.001). In summary, atorvastatin and simvastatin had similar LDL cholesterol lowering properties, but these drugs modified LDL transport and hepatic cholesterol metabolism differently.


Asunto(s)
Anticolesterolemiantes/farmacología , Ácidos Heptanoicos/farmacología , Hidroximetilglutaril-CoA Reductasas/metabolismo , Inhibidores de Hidroximetilglutaril-CoA Reductasas/farmacología , Hígado/efectos de los fármacos , Pirroles/farmacología , Simvastatina/farmacología , Análisis de Varianza , Animales , Atorvastatina , Colesterol/metabolismo , Cobayas , Lípidos/sangre , Lipoproteínas/sangre , Lipoproteínas/metabolismo , Lipoproteínas LDL/sangre , Lipoproteínas LDL/metabolismo , Hígado/enzimología , Hígado/metabolismo , Masculino
14.
Cortex ; 28(1): 129-34, 1992 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-1572169

RESUMEN

A 54-year-old, right-handed male suffered three sequential infarcts. The first two destroyed much of the right posterior parietal area, the posterior-medial portion of the right temporal lobe and virtually the entire right occipital lobe producing left homonymous hemianopsia and left visual neglect but no prosopagnosia. A third vascular accident involved the left parieto-occipital lobe and immediately produced prosopagnosia that has persisted. The sequential correlations of lesion and symptomatology in this case demonstrate that development of persistent prosopagnosia occurred only after bilateral damage.


Asunto(s)
Agnosia/fisiopatología , Infarto Cerebral/fisiopatología , Dominancia Cerebral/fisiología , Lóbulo Occipital/fisiopatología , Agnosia/diagnóstico , Agnosia/psicología , Infarto Cerebral/diagnóstico , Infarto Cerebral/psicología , Humanos , Recuerdo Mental/fisiología , Persona de Mediana Edad , Pruebas Neuropsicológicas , Reconocimiento Visual de Modelos/fisiología , Desempeño Psicomotor/fisiología , Tomografía Computarizada por Rayos X
15.
Thyroid ; 8(11): 1055-7, 1998 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-9848723

RESUMEN

Lingual thyroid is a rare developmental disorder and is more frequent in women. The pathogenesis is unclear but may be related to the presence of maternal blocking autoantibodies against the thyroid. Treatment of this disorder includes the use of levothyroxine in order to correct the hypothyroidism, which is very frequent and to induce the shrinkage of the gland. When symptoms of obstruction or bleeding appear, ablative therapy by means of surgery or radioiodine is warranted. We report three cases and discuss the approach to diagnosis and a strategy for management.


Asunto(s)
Coristoma/terapia , Glándula Tiroides , Enfermedades de la Lengua/terapia , Adolescente , Adulto , Niño , Coristoma/diagnóstico , Coristoma/radioterapia , Coristoma/cirugía , Femenino , Humanos , Imagen por Resonancia Magnética , Tiroxina/uso terapéutico , Lengua/patología , Enfermedades de la Lengua/diagnóstico , Enfermedades de la Lengua/radioterapia , Enfermedades de la Lengua/cirugía
16.
Arch Med Res ; 31(2): 182-5, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10880724

RESUMEN

BACKGROUND: Deliberate self-inhalation of solvents such as thinner is a recognized problem in underdeveloped countries, with chronic abuse resulting in neurological impairment. In this article, we use electronystagmography (ENG) to study optokinetic nystagmus abnormalities (OKN) that may be induced by thinner consumption. METHODS: Twenty-five patients exposed to thinner for 5-20 years, in an irregular fashion of consumption, were recruited from a toxicologic center. Twenty-five control subjects were invited to participate as volunteers matched by age (+/-2 years) and gender. At the time of evaluation, all had abstained from intoxicants for at least 4 weeks. ENG recordings were performed by clinicians masked to the patient's group. Clockwise and counterclockwise stimulation were performed at 20 and 40 degrees /sec. RESULTS: None of the patients showed spontaneous nystagmus during the test period. Differences between thinner abusers and controls on clockwise and counterclockwise OKN on number of beats of nystagmus elicited on the 40 degrees /sec velocity were identified. The thinner abusers group showed a lesser number of nystagmus (p level was 0.02 and 0.005, respectively). CONCLUSIONS: The present results confirm the sensibility of OKN as an early marker of solvent abuse. These results were obtained in middle-term chronic exposure to solvent mixtures and are in favor of both cortical and brainstem dysfunction.


Asunto(s)
Nistagmo Optoquinético/efectos de los fármacos , Solventes/farmacología , Trastornos Relacionados con Sustancias/fisiopatología , Adolescente , Adulto , Tronco Encefálico/fisiopatología , Corteza Cerebral/fisiopatología , Electronistagmografía , Femenino , Humanos , Masculino , Sensibilidad y Especificidad , Solventes/efectos adversos
17.
Arch Med Res ; 28(3): 401-6, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9291639

RESUMEN

The objective of this study was to assess the functional capacity for intracellular death (ID) and/or phagocytic index (PI) of polymorphonuclear cells of 24-h-old healthy newborns with respect to the PMN cells of adults using the same standard exogenous source of opsonins. The ID and PI techniques were standardized and 2-3 ml of blood were used. No differences were found in the percentages of ID, P, PI among the PMNs of the newborns and those of the adults: 43.95 +/- 15.70 vs. 44.56 +/- 8.43 for ID; 38.96 +/- 14.34 vs. 39.00 +/- 14.54 for P; 1.71 +/- 0.54 vs. 1.73 0.45 for PI, respectively. It was concluded that the PMNs of 24-h newborns have an ID, P, PI functionality comparable to adult PMNs; differences observed in PMN function in newborns may be due to humoral deficiencies (opsonins).


Asunto(s)
Recién Nacido/sangre , Neutrófilos/fisiología , Fagocitosis/fisiología , Adulto , Envejecimiento/sangre , Citotoxicidad Inmunológica , Humanos , Recién Nacido/inmunología , Neutrófilos/inmunología , Neutrófilos/microbiología
18.
Arch Med Res ; 28(3): 415-9, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9291641

RESUMEN

Pregnant women infected with hepatitis B and C viruses pose a risk for infecting their newborn infants by vertical transmission. We studied 6,253 pregnant women aged 12-49 years for infection with hepatitis B (HBV) and C (HCV) viruses. Infection was diagnosed by measuring IgG antibodies against HBc, HBs, HBe, as well as IgM-HBc and HCV viral antigens with commercially available immunoassay kits. HBV infection was detected in 113 cases (1.8%), and prevalence was significantly higher (2.4%) in a group of women with a high-risk pregnancy who were attending a perinatology hospital than in healthy pregnant women (1.67%, p < 0.05). Infection with HBV was significantly higher in women older than 30 years old (p < 0.05). HBsAg was found in blood, colostrum and vaginal exudate of two pregnant women; HBsAg was detected in the gastric aspirate but not in the blood of the two newborn infants. HBeAg and IgM-HBc were not detected in any of the samples. DNA-HBV was detected in serum of seven women, and DNA-HBV was detected in the gastric aspirate of only one of the newborns. HCV infection was diagnosed in three out of 111 women with markers for HBV infection (2.7%), and in 6 out of 1,000 women without these markers (0.6%). Anti-HCV antibodies were found in the serum of six of their infants during up to six months of age. Infants were monitored for one year and none of them developed any sign of hepatic disease. These results suggest that special attention should be paid to women older than 30 years and with a high-risk pregnancy, as they are at a higher risk of HBV and HCV infections.


Asunto(s)
Hepatitis B/transmisión , Hepatitis C/transmisión , Transmisión Vertical de Enfermedad Infecciosa , Complicaciones Infecciosas del Embarazo/virología , Adulto , Femenino , Hepatitis B/sangre , Hepatitis B/epidemiología , Hepatitis C/sangre , Hepatitis C/epidemiología , Humanos , Recién Nacido , Embarazo , Complicaciones Infecciosas del Embarazo/sangre , Factores de Riesgo
19.
Eur J Paediatr Neurol ; 5 Suppl A: 185-7, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11588994

RESUMEN

A 5-year-old boy presented with frequent absences. Speech began to regress. He became ataxic, barely able to walk. Studies with Xe-133 and hexamethylpropylene amine oxime single-photon emission computed tomography revealed sharply decreased cerebral blood flow, especially in the occipital area. Landau-Kleffner syndrome was suspected but a sleep electroencephalogram showed few abnormalities. He was started on clorazepate and diltiazem. A skin biopsy to rule out possible CLN2 revealed, instead of the predicted curvilinear profiles, granular osmiophilic deposits, consistent with infantile neuronal ceroid lipofuscinosis (CLN1). The family reported increased seizure frequency and consulted with a colleague, who advised them to resume valproate and discontinue diltiazem. The boy died shortly thereafter. Decreased cerebral blood flow is a new finding in CLN1 with delayed onset. Calcium-channel blockers improve cerebral blood flow and perhaps delay clinical regression.


Asunto(s)
Circulación Cerebrovascular , Proteínas de la Membrana , Lipofuscinosis Ceroideas Neuronales/diagnóstico por imagen , Lipofuscinosis Ceroideas Neuronales/fisiopatología , Edad de Inicio , Biopsia , Preescolar , Gránulos Citoplasmáticos/patología , Gránulos Citoplasmáticos/ultraestructura , Resultado Fatal , Humanos , Masculino , Microscopía Electrónica , Lipofuscinosis Ceroideas Neuronales/patología , Neuronas/patología , Lóbulo Occipital/irrigación sanguínea , Lóbulo Temporal/irrigación sanguínea , Tioléster Hidrolasas , Tomografía Computarizada de Emisión de Fotón Único , Tripeptidil Peptidasa 1
20.
Acad Emerg Med ; 3(4): 352-9, 1996 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-8881545

RESUMEN

OBJECTIVE: To review the types of injuries due to law enforcement (K-9) dog bites and address related management issues. METHODS: A case series of law enforcement dog bite victims is reported and related literature reviewed. RESULTS: Law enforcement dogs are taught a bite-and-hold technique for subduing individuals suspected of felony crimes. This bite-and-hold technique's greater applied force results in a unique spectrum of injuries, including deep puncture wounds, severe crush injuries, large tissue avulsions and lacerations, wounds necessitating surgical débridement, bony injuries ranging from cortical violations to displaced fractures, neurovascular damage, and other wounds at high risk for infection. The four reported cases highlight the types of injuries and complications associated with law enforcement dog bites. CONCLUSION: Attention to potential deep injuries of nerves, vessels, and the musculoskeletal system is essential with law enforcement dog bites. Injuries associated both with pursuit and arrest and with the bites themselves must be identified and assessed. Guidelines for the ED treatment of patients with law enforcement dog bite injuries are proposed.


Asunto(s)
Mordeduras y Picaduras/terapia , Perros , Servicio de Urgencia en Hospital , Policia , Adolescente , Adulto , Animales , Mordeduras y Picaduras/diagnóstico , Mordeduras y Picaduras/fisiopatología , Terapia Combinada , Humanos , Masculino , Guías de Práctica Clínica como Asunto , Resultado del Tratamiento , Heridas y Lesiones/diagnóstico , Heridas y Lesiones/fisiopatología , Heridas y Lesiones/terapia
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