1.
J Med Chem
; 24(6): 727-31, 1981 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7252982
RESUMEN
A novel series of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[beta-[4-(beta-phenylethyl)phenyl]-beta-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.
Asunto(s)
Anticonvulsivantes , Imidazoles/farmacología , Animales , Femenino , Imidazoles/síntesis química , Masculino , Ratones , Fenobarbital/farmacología , Fenitoína/farmacología , Convulsiones/tratamiento farmacológico , Relación Estructura-Actividad
2.
Boll Chim Farm
; 120(3): 185-90, 1981 Mar.
Artículo
en Italiano
| MEDLINE
| ID: mdl-7272022
3.
Boll Chim Farm
; 118(7): 397-406, 1979 Jul.
Artículo
en Italiano
| MEDLINE
| ID: mdl-526358