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6.
Ir Med J ; 107(3): 85-7, 2014 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-24757895

RESUMEN

A significant amount of valuable undergraduate medical teaching may be informal, unscheduled and delivered by non-consultant hospital doctors (NCHDs). 800 Questionnaires were distributed to consultants, NCHDs and medical students in Irish teaching hospitals. The aim was to quantify the level of unscheduled teaching carried out in these hospitals and the manner in which it was performed. The response rate was 46% (364/800). 71% of doctors who replied are independently teaching undergraduate medical students (77/109), including 71% of interns and senior house officers (48/68). Students tend to prefer small group teaching. Fifty-six percent of students suggest they would benefit from more surgical teaching time (144/255). No interns surveyed were scheduled to teach as part of a formal curriculum. A significant amount of unscheduled teaching by interns and senior house officers takes place in Irish hospitals. It may prove beneficial to incorporate interns into scheduled surgical teaching curricula.


Asunto(s)
Actitud del Personal de Salud , Educación de Pregrado en Medicina , Cirugía General/educación , Enseñanza , Curriculum , Educación de Pregrado en Medicina/métodos , Educación de Pregrado en Medicina/organización & administración , Hospitales de Enseñanza , Humanos , Irlanda , Cuerpo Médico de Hospitales/psicología , Evaluación de Necesidades , Estudiantes de Medicina/psicología , Encuestas y Cuestionarios
7.
Br J Dermatol ; 169 Suppl 2: 1-8, 2013 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-23786614

RESUMEN

Mitochondria constitute an important topic of biomedical enquiry (one paper in every 154 indexed in PubMed since 1998 is retrieved by the keyword 'mitochondria') because of widespread recognition of their importance in cell physiology and pathology. Mitochondrial dysfunction is widely implicated in ageing and in the diseases of ageing, through dysfunction in adenosine triphosphate (ATP) synthesis, Ca(2+) homeostasis, central metabolic pathways or radical production. Nonetheless, the mechanisms and regulation of superoxide and hydrogen peroxide formation by mitochondria remain poorly described. Measurement of the capacities of different sites of superoxide and hydrogen peroxide production in isolated skeletal muscle mitochondria show that the maximum capacities of sites in complexes I, II and III and in several associated redox enzymes greatly exceed the native rates observed in the absence of respiratory chain inhibitors. In vitro, the native rates and the relative importance of different sites both depend on the substrate being oxidized, with sites IQ, IIF, GPDH, IF and IIIQo each being important with particular substrates. The techniques involved in measuring rates from each site should become applicable to cell cultures and in vivo in the future.


Asunto(s)
Envejecimiento/fisiología , Metabolismo Energético/fisiología , Mitocondrias/fisiología , Enfermedades Mitocondriales/metabolismo , Adenosina Trifosfato/metabolismo , Calcio/metabolismo , Humanos , Peróxido de Hidrógeno/metabolismo , Superóxidos/metabolismo
9.
Ir Med J ; 105(9): 308-9, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23240286

RESUMEN

We relate the first case in the Republic of Ireland of Cronkhite Canada Syndrome (CCS). The patient presented with weight loss, alopecia, nail dystrophy, taste disturbance and classic radiologic and endoscopic features of CCS. She continued to dramatically lose weight and early repeat colonoscopy showed the interim development of an invasive sigmoid adenocarcinoma.J


Asunto(s)
Adenocarcinoma/complicaciones , Adenocarcinoma/diagnóstico , Poliposis Intestinal/complicaciones , Poliposis Intestinal/diagnóstico , Neoplasias del Colon Sigmoide/complicaciones , Neoplasias del Colon Sigmoide/diagnóstico , Adenocarcinoma/cirugía , Anciano , Colonoscopía , Femenino , Humanos , Poliposis Intestinal/patología , Neoplasias del Colon Sigmoide/cirugía
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