Primary diffuse leptomeningeal oligodendrogliomatosis with an isolated 1p deletion.

We report a case of primary diffuse leptomeningeal oligodendrogliomatosis with an isolated 1p deletion confirmed by fluorescent in situ hybridization (FISH) analysis in 52 year-old man. The MRI scan in a patient presenting with progressive headache, nausea and diplopia revealed diffuse leptomeningeal thickening and enhancement without definitive evidence of an intraparenchymal lesion. Biopsy of thickened, enhancing meninges within the left sylvian fissure revealed subarachnoid proliferation of oligodendroglial cells with varying degrees of de-differentiation and sparing of the underlying cortex. An isolated 1p deletion was confirmed by FISH analysis. This is the first reported adult case of a 1p deletion in primary diffuse leptomeningeal oligodendrogliomatosis.

Successful embolization of an upper cervical spinal dural fistula despite anterior spinal artery anastomosis.

A female in her 40s presented with classic symptoms of subarachnoid hemorrhage and limited mobility of the bilateral upper extremities. Imaging demonstrated a minor amount of subarachnoid blood, and a follow-up computed tomography angiogram revealed a spinal dural arteriovenous fistula (SDAVF) located at C2-3. The C2-3 radicular artery proximal to the fistula feeder anastomosed with the anterior spinal artery, challenging the safety of embolization. However, surgical treatment of the SDAVF would require a suboccipital craniotomy due to its proximity to the foramen magnum, so possible embolization based on lidocaine provocative test results was decided upon. Neurologic examination of the patient following lidocaine provocative testing suggested that embolization could be performed safely. Glue embolization was successfully performed, and the patient awoke without complications. Subsequent imaging revealed no filling of the medullary vein that previously drained the fistula.

Reversible Cerebral Vasoconstriction Syndrome Following Exposure to Oleoresin Capsicum "Pepper Spray".

OBJECTIVES: To report a case associating the use of Oleoresin Capsicum Pepper Spray (OCPS) during law enforcement training with development of Reversible Cerebral Vasoconstriction Syndrome (RCVS). MATERIALS AND METHODS: RCVS is radiographically characterized by multifocal smooth narrowing of cerebral arteries heralded by clinical manifestations of recurrent thunderclap headaches. 70% of cases with RCVS have a clear precipitating factor and agents commonly implicated were cannabis, selective serotonin reuptake inhibitors, nasal decongestants, cocaine, postpartum state, eclampsia and strenuous physical/sexual activity.1 RESULTS: 24-year-old female police officer with no past medical history who presented with thunderclap headaches after exposure to pepper spray to her face during work training. Neurological examination was unremarkable. CT angiogram (CTA) of the head and neck and subsequent conventional angiogram revealed multifocal mild arterial narrowing of bilateral middle cerebral arteries (MCA), bilateral posterior cerebral arteries (PCA) and left anterior cerebral artery (ACA) concerning for RCVS. Eight weeks later, she had a repeat MRA head and neck demonstrating complete resolution of the previously noted narrowing of her cerebral arteries. CONCLUSIONS: OCPS is widely used in law enforcement training as well as by general population as a self- defense tool. It is generally assumed to be safe, although the consequences of its use can never be predicted with certainty.2 As our case highlights, use of OCPS may be associated with development of RCVS and awareness needs to be raised regarding this rare but serious complication.

Anatomical and surgical considerations for Bow Hunter's syndrome in an elderly patient.

Bow Hunter's syndrome (BHS) is an uncommon condition characterized by impingement of one of the two vertebral arteries induced by cervical rotation, causing symptomatic vertebrobasilar insufficiency of the posterior cerebral circulation. We report a case of BHS in an 84-year-old male. Two months following a motor vehicle accident, the patient presented to an urgent care facility with subsequent transfer to the emergency department with complaints of lightheadedness upon right-lateral head movement. A cerebral angiogram demonstrated mild focal stenosis in the dominant left vertebral artery at the C2 level when in neutral position with significant worsening of the stenosis in the right-lateral head position with absent anterograde flow, consistent with BHS. Resultantly, the patient was referred for neurosurgery and successfully underwent placement of right-sided C2-C4 postero-lateral instrumentation and left-sided C2-C3 laminar screws projected towards the right side. This case highlights the importance of imaging in BHS diagnosis and guidance for treatment, as well as the need for a surgical standard of care for BHS patients.

A complicated presentation of vertebral coccidioidomycosis dissemination: A case report and discussion.

Coccidioidomycosis, also known as San Joaquin Valley fever, is an illness caused by the dimorphic fungus Coccidioides. Coccidioidomycosis is endemic to desert regions of the Western Hemisphere, including California, Arizona, Utah, Nevada, and New Mexico. We report a case of disseminated coccidioidomycosis in a 42-year-old male. Months after an upper respiratory infection of unidentified origin, the patient began experiencing back pain. The persistence of the back pain prompted MRI and CT imaging, which revealed lytic lesions. His clinical and radiological presentation mimicked, and was originally approached, as if it were a malignancy. Metastasis or multiple myeloma were considered the most likely differential diagnoses. As a result, the patient underwent surgical exploration. Pathology results indicated the presence of a fungal infection, without evidence of malignancy. PCR confirmed the diagnosis of coccidioidomycosis. The patient began treatment with fluconazole 800 mg daily and is anticipated to receive antifungal treatment for an indefinite period.

Ischemic optic neuropathy following craniotomy.

Ischemic optic neuropathy is one of the major causes of severe impairment of vision often leading to blindness. It has varied etiopathogenesis with limited management options and very often result in poor outcome. Perioperative ischemic optic neuropathy is rare and particularly seen in elderly patients with multiple comorbidities undergoing cardiac or spine surgery. We present a case of young patient who developed ischemic optic neuropathy following craniotomy for recurrent meningioma. Keywords: Ischemic optic neuropathy; optic nerve vasculature; painless vision loss; perioperative complications; perioperative optic nerve ischemia.

The Rationale Behind Transcirculation Neuroendovascular Interventions: Literature Review Through a Case-Series Approach.

BACKGROUND: With the development of advanced endovascular techniques and materials, neurointerventionalists can perform challenging and complex cases that were previously difficult to perform. Transcirculation approaches could be a useful tool used in complicated cases, providing access to the target vessel, through the contralateral or opposite circulation, when anterograde access is difficult or nonachievable. OBJECTIVE: To retrospectively review cerebrovascular interventions performed through a transcirculation approach performed by staff at our Institution. METHODS: English-language studies, published until August 2022, reporting transcirculation interventions in the cerebrovascular circulation were retrospectively collected. Type of intervention, number of cases, rationale, and complications were analyzed. Furthermore, similar cases performed by staff currently at our institution were also reviewed and described. RESULTS: Including our cases, a total of 273 transcirculation treatment approaches have been reported. Intracranial aneurysm embolization, stroke thrombectomies, intra-arterial ophthalmic chemotherapy, arteriovenous malformationss, arteriovenous fistulas embolizations, and intracranial angioplasty and stenting are common indications. Reason for using a retrograde approach were stent/balloon-assisted coiling of wide neck aneurysm in 116 cases, difficult angulation of branch in 91 cases, occlusion of parent vessel in 55 cases, and bailout/other in 11 cases. CONCLUSION: Transcirculation approaches can be considered for cases where conventional anterograde treatment options are not feasible or as a bailout strategy in failed or complicated treatment attempts. They represent a strategy to consider when facing challenging cases, and if performed by experienced and dedicated neurointerventionalists, they can represent a safe alternative.

Aplastic Internal Carotid Artery: A Potentially Catastrophic Vascular Anomaly.

Congenital absence of an internal carotid artery (ICA) is a rare vascular anomaly and occurs in less than 0.01% of the population. We report a case of aplastic internal carotid artery in a 34-year-old female. The patient presented to the emergency department with complaints of new-onset involuntary swaying-like movement of her right arm. Brain magnetic resonance imaging showed multifocal tiny areas of acute infarcts in the bilateral frontal, parietal, and left occipital lobes in the watershed distribution. There was no visualization of the flow of the intracranial left internal carotid artery. Follow-up CTA of the head and neck showed a congenital absence of the left internal carotid artery with no evidence of arterial dissection, occlusion, or aneurysm. Obstruction of the internal carotid artery has significant consequences for patients. This effect is amplified if the disruption occurs in the sole anterior blood supply to the parenchyma of the brain, as in this case. In our patient care, imaging was vital to the detection and subsequent treatment with anticoagulation to avoid further cerebral complications, and the patient will now have a better understanding of the increased lifetime risk of further events.

CT perfusion imaging pitfall related to fetal posterior cerebral artery.

OBJECTIVE: The purpose of this article is to discuss how a unilateral fetal posterior cerebral artery (PCA) causes perfusion map asymmetry due to anteroposterior bolus arrival discrepancy. We performed region of interest analysis of asymmetric perfusion maps before and after delay correction was performed. CONCLUSION: Perfusion asymmetry becomes unapparent using a delay correction algorithm, indicating bolus arrival delay on the side opposite the fetal PCA. Delay correction algorithms can eliminate deconvolution errors related to bolus arrival delay.

Transradial embolization of a life-threatening tooth extraction socket hemorrhage and pseudoaneurysm.

Embolization of oral hemorrhages due to tooth extraction, although rare, has been previously described.1-4 In this video we present a unique case in which a life-threatening tooth extraction hemorrhage was incontrollable with local compression or surgical cauterization. The patient underwent emergent transradial coil embolization5 of the posterior lateral nasal branches of the sphenopalatine artery. However, the patient returned 11 days later with a lower volume bleed at the original site. Computed tomography angiography showed a pseudoaneurysm at the orthognathic surgery crater retrogradely recanalized through the greater palatine arcade. Surgical options were deemed too invasive, and the decision was made to attempt percutaneous direct puncture embolization. This was unsuccessful and repeat embolization with Onyx was performed through the contralateral greater palatine artery. The patient had complete resolution of symptoms.

Pneumocele of the frontal sinus producing orbital roof defect: case report and review of literature.

Type III frontal recess air cell as a cause of frontal sinus pneumocele has not been previously reported in literature. A 31-year-old woman with chronic history of sinusitis presented with pressure in the left eye on blowing the nose. Computed tomography examination of the orbits and paranasal sinuses with coronal and sagittal reformatted images showed abnormal collection of gas in the soft tissues at the superior aspect of the left orbit contiguous with the overlying left frontal sinus through a large defect in the orbital roof and a type III frontal recess air cell narrowing the left frontal recess.

The face of hillbilly heroin and other images of narcotic abuse.

The nationally recognized popularity of recreational intranasal oxycodone abuse among rural Appalachians is apparent to West Virginian healthcare providers. Three recent cases of narcotic-induced injury at WVU Ruby Memorial Hospital demonstrate the facial bone necrosis associated with "hillbilly heroin" abuse as well as other imaging features of narcotic-induced intracranial ischemia. This paper shows how diagnostic imaging may facilitate clinical evaluation of patients with narcotic abuse.

Pediatric spinal cord infarction following a minor trauma: a case report.

INTRODUCTION: Pediatric spinal cord infarction is a rare entity that presents a diagnostic challenge at the emergency department. Ischemic spinal cord infarction can occur in the setting of trauma, cardiovascular malformation, or postoperatively. We report a case of anterior spinal artery infarction following seemingly minor trauma in an otherwise healthy 14-year-old male. CASE PRESENTATION: A 14-year-old male presented with unprovoked sudden-onset stabbing back pain earlier that day. The patient then demonstrated bilateral lower extremities weakness while at the emergency department. After extensive diagnostic workup, the patient was diagnosed with anterior spinal artery territory infarction involving the thoracic spinal cord. Minor trauma to the thoracic spinal cord was detected on imaging and was believed to be the culprit of this event. DISCUSSION: Given the rarity of spinal cord ischemia, a high index of suspicion and extensive workup of patients presenting with clinical weakness are needed for accurate diagnosis and to avoid the eventual poor outcome. With so few reports in the literature regarding spinal cord ischemia in the pediatric population, accurate diagnosis is often delayed until after irreversible events have already taken place. Our case report of anterior spinal artery distribution thoracic cord infarct following a minor trauma was diagnosed by axial thin-slice DWI MRI with an otherwise negative workup.

Occlusion time for Amplatzer vascular plug in the management of pulmonary arteriovenous malformations.

OBJECTIVE: The occlusion time, that is, the interval between device deployment and complete occlusion of the vessel, associated with the use of embolic devices influences the risk of embolic complications caused by small clots that can form over the surface of a device and break away. The purpose of our study was to determine the time for an Amplatzer vascular plug to bring about percutaneous transcatheter occlusion of a pulmonary arteriovenous malformation (PAVM). MATERIALS AND METHODS: We retrospectively studied the occlusion times of Amplatzer vascular plugs in the management of 12 PAVMs. We recorded the number, location, type (simple or complex), and diameter and number of feeding arteries of PAVMs; the number and size of devices needed to occlude each PAVM; and the occlusion time for each PAVM. The occlusion time is the time interval from device placement to complete occlusion of the PAVM. Occlusion time was determined by recording the time between acquisition of the first angiographic image after deployment of the device and the angiogram that showed total occlusion of the PAVM. The relevant literature on the subject was reviewed. RESULTS: All PAVMs managed were supplied by a single feeding artery. The average diameter of the feeding arteries was 4.8 mm (range, 3.0-11.2 mm). All PAVMs were occluded by deployment of a single Amplatzer vascular plug. Vascular plug sizes ranged from 4 to 16 mm. The mean occlusion time was 3 minutes 20 seconds (range, 1 minute 49 seconds-5 minutes 16 seconds). There were no immediate complications, including air embolism and thromboembolism. CONCLUSION: The occlusion time determined in our study and the need to place only one Amplatzer vascular plug in each feeding artery to achieve complete occlusion in most cases suggest that the device is safe for management of PAVM with no increased risk of systemic embolization. The use of the Amplatzer vascular plug for PAVM embolization is a relatively recent development. Long-term follow-up studies are needed to assess recanalization rates, radiation exposure rates, and risk of device migration.

Condylar jugular diverticulum.

We would like to present 6 instances of an internal jugular bulb diverticulum extending into the occipital condyle, which, to the best of our knowledge, has not been described in the English-language literature.This asymptomatic variant was detected incidentally on 6 patients. Computed tomography was performed on all 6 cases, and magnetic resonance imaging and magnetic resonance venography was performed in 2 cases. The condylar jugular diverticula presented as a well-defined defect in the occipital condyle contiguous with the jugular bulb on computed tomography. Magnetic resonance venography showed flow within the diverticulum. There was no definite relationship to a dominant transverse sinus. Recognition of this variant will help to avoid potential confusion with pathological lesions in the occipital condyle, especially on magnetic resonance imaging.

Isolated trochlear nerve (cranial nerve IV) palsy in a patient with carotid-cavernous fistula.

Isolated fourth cranial (trochlear) nerve palsy is an uncommon occulomotor nerve palsy typically secondary to ischemia, inflammation/infection, or mass effect. Due to its positioning within the cavernous sinus, pathology of the deep cerebral venous system would theoretically predispose to palsy of this nerve. We present a case of a patient presenting with isolated trochlear nerve palsy in the setting of angiographically-confirmed direct carotid-cavernous fistula.

Assessment of the Inferior Petrosal Sinus on T1-Weighted Contrast-Enhanced Magnetic Resonance Imaging.

CONTEXT: Skull base venous anatomy. AIMS: While prior studies have focused on the efficacy of conventional fluoroscopic venography and multidetector computed tomography venography to evaluate the inferior petrosal sinus (IPS) before image-guided intervention (such as dural venous sinus sampling), we believe that routine magnetic resonance imaging (MRI) may provide reliable structural information helpful for planning without the need for further imaging. SETTINGS AND DESIGN: Retrospective review of brain MRI. MATERIALS AND METHODS: Retrospective analysis was carried out on IPSs on contrast-enhanced T1-weighted MR images. Qualitative measurements were made regarding the grade of patency of the IPS, variation in IPS drainage pattern, and grading of the ipsilateral transverse and sigmoid sinuses (TS and SS). STATISTICAL ANALYSIS USED: Pearson's product-moment correlation. RESULTS: Evaluation of a total of 148 IPSs revealed that 91% of cases were grade 3 or grade 2 (either fully or mostly visualized), with 65% of cases demonstrating "typical" (type A) drainage directly into the internal jugular vein and no statistically significant correlation between the patency of the IPS and the dominance of the ipsilateral TS/SS. A bilateral concordance rate of 77% was also observed. CONCLUSIONS: Our analysis indicates that routine thin-slice contrast-enhanced T1-weighted MRI can provide sufficient anatomic detail to identify typical drainage pattern of the IPS in a majority of cases. In cases where routine drainage was not identified, spatial resolution was not sufficient to further delineate complex drainage anatomy. No correlation was observed between the TS/SS dominance and patency of the ipsilateral IPS.

Relationship between stroke recurrence, infarct pattern, and vascular distribution in patients with symptomatic intracranial stenosis.

OBJECTIVE: In view of recent literature suggesting that stroke recurrence and risks related to intervention may be related to plaque physiology/instability, our study sought to discern the pattern of stroke and rates of stoke recurrence as they relate to the anatomy and presentation of the underlying stenosis. METHODS: Retrospective chart as well as CT and MR angiographic imaging review of patients in the institutional stroke database was performed, including identification of patient risk factors, medical therapeutic optimization, compliance, serum cholesterol (low density lipoprotein) levels, blood pressure, physical therapy referrals, follow-up clinical status (using the modified Rankin Scales), and rate of recurrent stroke. 39 patients met the inclusion criteria. We evaluated infarct pattern (embolic, adjacent perforator, or watershed) and vascular distribution. RESULTS: Basilar artery stenosis was most likely to present as a perforator stroke and least likely to recur. Patients discharged with suboptimal medical therapy were twice as likely to have a recurrent stroke. Among patients with optimized medical therapy, no recurrent strokes were seen in patients with an embolic infarct pattern, while a 57% recurrence rate was seen in patients with a watershed infarct pattern. CONCLUSIONS: Our results suggest that hemodynamic intracranial vascular stenoses may be less responsive to medical therapy, while stenotic lesions caused by plaque destabilization or in perforator territories may benefit from aggressive medical management with delayed or staged endovascular therapy. Recurrence of stroke may be affected both by vascular territory and by aggressive risk factor control, although the latter remains difficult to evaluate.

Benign triton tumor of the trigeminal nerve.

Benign triton tumors (neuromuscular hamartomas) are rare neoplasms composed of well-differentiated striated muscle fibers admixed with peripheral nerve fibers. To the best of our knowledge, this is the third case reported in the world literature of a benign triton tumor involving cranial nerve V (trigeminal nerve) and the first in the radiology literature. The previous reports of this lesion have focused on its unusual pathology and not on the imaging findings. In light of the imaging appearance of this lesion, we consider that the imaging findings may suggest this uncommon diagnosis.

Thoracic intradural extramedullary capillary hemangioma.

We report a case of a thoracic intradural extramedullary capillary hemangioma. The MR imaging appearance was nonspecific for this lesion, and it could not be distinguished from more common spinal intradural extramedullary lesions. The presence of subtly enlarged abnormal vessels on contrast MR images should, however, lead one to consider a vascular mass and order preoperative spinal arteriography.