Lamotrigine induced subacute cutaneous lupus erythematous.

A 48-year-old woman developed drug-induced subacute lupus erythematosus while taking lamotrigine. The eruption resolved after discontinuance of lamotrigine, suggesting this drug as the cause.

[Prevalence and clinical features of congenital melanocytic nevi in 1,000 Spanish newborns]. / Prevalencia y características clínicas de los nevos melanocíticos congénitos en 1.000 recién nacidos españoles.

BACKGROUND: Congenital melanocytic nevus is a benign proliferation of melanocytes that is present at birth or develops in the first months of life. Although such lesions are common, few studies have analyzed their prevalence in Spain. OBJECTIVES: The aim of this study was to define the prevalence and most frequent anatomical areas affected by congenital melanocytic nevi in our health service area. We also analyzed the influence of maternal and neonatal factors in the development of these lesions. PATIENTS AND METHODS: We performed a prospective study of 1000 consecutive neonates seen in the first 72hours of life in the perinatology clinic of the Pediatrics Department of Hospital Arquitecto Marcide in Ferrol, Spain, recording specific maternal and neonatal variables and the size and site of congenital melanocytic nevi if present. RESULTS: Fourteen infants (10 girls and 4 boys; 12 white European, 2 North African; 1.4% of the study population) presented at least 1 melanocytic nevus. None had more than 1 lesion. Eight of the nevi were located on the trunk, 2 on the face, 2 on the upper limbs, and 2 on the lower limbs. The diameter of the lesions was less than 1.5 cm in half of cases and between 1.5 and 3.5 cm in the remainder. CONCLUSIONS: There was a higher prevalence of congenital melanocytic nevi in preterm infants, females, and nonwhite infants. Maternal age, number of previous pregnancies, and birth weight do not appear to influence the prevalence of these lesions.

[Influence of neonatal and maternal factors on the prevalence of vernix caseosa]. / Influencia de los factores neonatales y maternos en la prevalencia de vérnix caseosa.

At birth, vernix caseosa can cover the whole body surface or accumulate only on the back and in the skin folds. Interest in its composition and function and its possible applications in adults has increased in recent years. The objective of this study was to determine the prevalence of vernix caseosa in newborn infants in the health care area of Ferrol, Spain, and to assess its relationship with neonatal and maternal factors. We performed a prospective study of 1000 newborns seen within the first 3 days of life in our hospital. Vernix caseosa was observed in 42.9% of cases. The clinical profile associated with the presence of vernix caseosa was the following: healthy newborn girl with a high birth weight, born at term by normal vaginal delivery to a multiparous mother who had received medication and dietary supplements during pregnancy. The absence of vernix caseosa was associated with the presence of physiological scaling of the newborn and erythema toxicum neonatorum.

[Cutaneous collagenous vasculopathy: a case report and review of the literature]. / Vasculopatía colágena cutánea: aportación de un caso y revisión de la literatura.

Cutaneous collagenous vasculopathy is an idiopathic microangiopathy first described in 2000 by Salama and Rosenthal.It must not be confused with generalized essential telangiectasia. To date, all patients have been white men over the age of 50 years, most of whom had multiple pathologies, were taking multiple drugs, and had no family history of similar conditions or hemorrhagic disorders. The disease is characterized by the development of various numbers of telangiectases on the limbs, lower abdomen, chest, or back, with no involvement of the mucosas or nail bed. Histopathology shows dilated superficial cutaneous vessels with perivascular deposits of periodic acid-Schiff diastase-positive, eosinophilic hyaline material that exhibits positive immunoreactivity to collagen IV. We report a new case in a 68-year-old man with symmetrically distributed telangiectases on his forearms, lower abdomen, posterior thighs, lower legs, and dorsum of the feet.

[Recurrent vulvovaginitis: diagnostic assessment and therapeutic management]. / Vulvovaginitis de repetición. Valoración diagnóstica y manejo terapéutico.

Recurrent vulvovaginitis is a common problem in clinical practice. Management is often complicated by a long history of inappropriate treatments based on tentative diagnoses after an incomplete diagnostic workup. We review the most common causes of recurrent vulvovaginitis; the appropriate steps with which to establish a diagnosis, from the medical history through to the additional tests needed; and, finally, the best therapeutic options. We will focus on infectious, irritant, allergic, and hormonal causes as the ones of most interest to the dermatologist. Given that infection is the most frequent cause of these processes and also a common reason for inopportune treatment, we will pay particular attention to infectious etiologies and their differential diagnosis.

[Localized cutaneous amyloidosis secondary to porokeratosis: a retrospective histopathologic study of 30 patients]. / Amiloidosis cutánea localizada secundaria a poroqueratosis. Estudio histopatológico retrospectivo de 30 pacientes.

INTRODUCTION: Porokeratosis is a rare disorder of keratinization. The presence of amyloid deposits has been observed in inflammatory and tumoral skin diseases. OBJECTIVES: The aim of this study was to determine the frequency of cutaneous amyloidosis in histology samples from various types of porokeratosis diagnosed in our department from 1988 to 2005. MATERIAL AND METHODS: Thirty patients were selected and 34 biopsies of lesions clinically and histologically compatible with porokeratosis were performed. Sections were stained with hematoxylin-eosin and thioflavin T. RESULTS: Amyloid deposits were observed in 11 biopsies from 9 patients. Most were women in their sixties, with disseminated superficial actinic porokeratosis that had begun at least 5 years earlier. No notable histologic differences were observed between porokeratosis specimens with and without amyloid deposits. CONCLUSIONS: The coexistence of porokeratosis and amyloidosis is a rare occurrence but may be underdiagnosed. In our opinion, the advanced age of the patients and the chronic nature of the lesions would have been predisposing factors for amyloid deposition. The possibility of racial or genetic influences, however, cannot be ruled out.

Tumores faciales en un paciente con múltiples neoplasias / Facial tumours in a patient with multiple neoplasms

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Estudio prospectivo de la hiperpigmentación del área genital en recién nacidos españoles: frecuencia y factores predisponentes / Prospective study of hyperpigmentation of the genital area in Spanish newborns: frequency and predisposing factors

Realizamos un estudio prospectivo de 1.000 recién nacidos vistos en las primeras 72 horas de vida en el Área Sanitaria de Ferrol (noroeste de España)con el objetivo de conocer la prevalencia de la hiperpigmentación del área genital y ver como influyen, en su aparición, los factores neonatales y maternos, el momento de exploración y la modalidad de parto. La frecuencia de la hiperpigmentación genital fue del 15,3%. Encontramos una prevalencia superior en los neonatos no caucásicos (p = 0,000) de sexo masculino (p = 0,000), con mancha mongólica (p = 0,000), nacidos por vía vaginal (p =0,030) y con madre menor de 30 años (p = 0,006) y con al menos 2 gestaciones previas (p = 0,015) (AU)

We performed a prospective study of 1,000 neonates investigated in the first 72 hours of life in the Health Area of Ferrol (northwest of Spain), in order to assess the prevalence of hyperpigmentation of the genital area, the influence of different maternal and neonatal parameters, day of neonatalexploration and type of delivery. Overall frequency of hyperpigmentation was 15.3%. We found a higher prevalence of this dermatosis in non-Caucasian infants (p = 0.000) of male sex (p = 0.000), with Mongolian spot (p = 0.000), vaginal delivery (p = 0.030), maternal age below 30 years (p =0.006) and at least two previous pregnancies (p = 0.015) (AU)